Acute Arsenical Poisoning Due to Acetarsol Pessaries

Bowen, D. A. L.; Lewis, Terri L.; Edwards, W. R.

doi:10.1136/bmj.1.5235.1282

Cited by 14 publications

(6 citation statements)

References 4 publications

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“…40 However, a small randomized prospective trial comparing nonoxynol-9 with metronidazole 41 found a cure rate of only 17.6% versus 100% (and all nonoxynol-9 failures subsequently responded to metronidazole), so further studies are needed. Acetarsol: This arsenical compound is only available on a named patient basis (Martindale Pharmacies will manufacture it on request and it is also available from Novolabs 42 ) following its withdrawal from general use (acetarsol pessaries were associated with one death, although the compound was used in very high dosage 43 ). There have been reports of success 44,45 and failure 42 of treatment with acetarsol.…”

Section: Discussionmentioning

confidence: 99%

Recalcitrant Trichomonas vaginalis infection – a case series

et al. 2005

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The objective of this study was (1) to estimate the prevalence of recalcitrant Trichomonas vaginalis (TV) infection in a UK genitourinary medicine clinic; (2) to use a case series and literature review to suggest an algorithm for management of recalcitrant TV (rTV). A retrospective review of laboratory records, case-notes and literature review was conducted. Fifteen patients were studied, representing 1.16% of the cases presenting during the study period. A wide variety of therapeutic agents was used, the treatment regimen differed for each patient. No treatment was universally effective in achieving cure, but the use of acetarsol pessaries vaginally appeared to be the most frequently successful strategy. Based on these results, an algorithm for treatment of rTV is presented, although clinical trials will be needed to elucidate the best clinical approaches to this problem.

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Section: Discussionmentioning

confidence: 99%

Recalcitrant Trichomonas vaginalis infection – a case series

et al. 2005

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“…Generalized cutaneous eruptions, including exfoliative dermatitis, have been reported although these are comparatively rare 17 . In one case, death occurred following the administration of an exceptionally high dose of 30 acetarsol pessaries over a 2-day period 18 .…”

Section: Discussionmentioning

confidence: 99%

Acetarsol Pessaries in the Treatment of Metronidazole Resistant Trichomonas Vaginalis

Chen

Fox

et al. 1999

Int J STD AIDS

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“…A fatal case of arsenic poisoning followed the treatment of trichomoniasis by packing the vagina with 18 acetarsol pessaries and a further 12 pessaries 2 days later 10 . However the administration of acetarsol as a 250 mg suppository twice daily for 4 weeks in the successful management of otherwise unresponsive ulcerative proctitis, appeared to be safe 11 .…”

Section: Discussionmentioning

confidence: 99%