Acute Arterial Hemorrhage Following Radiotherapy of Oropharyngeal Squamous Cell Carcinoma

Greve, Jens; Baş, Murat; Schuler, Patrick J.; Turowski, Bernd; Scheckenbach, Kathrin; Budach, Wilfried; Bölke, Edwin; Bergmann, Christoph; Lang, Stephan; Arweiler‐Harbeck, Diana; Lehnerdt, Goetz; Mattheis, Stefan; Bier, H.; Hoffmann, Thomas

doi:10.1007/s00066-010-2114-5

Cited by 19 publications

(46 citation statements)

References 18 publications

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“…Massive tumor bleeding and carotid blowout syndrome are lifethreatening conditions in HNC patients. These complications occur in patients with treatment refractory, ulcerative tumors because of vessel erosion, wound infections, or more commonly with recurrent disease [42,43]. However, they are rare within the first 6 months after diagnosis and often occur at later stages, that is, with disease recurrence and with reirradiation.…”

Section: Treatment-related Complicationsmentioning

confidence: 97%

Early death among head and neck cancer patients

Farnebo

Malila

Mäkitie

et al. 2016

Current Opinion in Otolaryngology & Head and Neck Surgery

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Section: Treatment-related Complicationsmentioning

confidence: 97%

Early death among head and neck cancer patients

Farnebo

Malila

Mäkitie

et al. 2016

Current Opinion in Otolaryngology & Head and Neck Surgery

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“…[12][13][14] Although prior or repeated CRT seem to be the most frequent preconditions in patients with CBS, longitudinal data analysis for predicting the contributions of different risk factors is still lacking. 3,[15][16][17] In the present study, a total of 36 patients with CBS within a comprehensive, large sample-size HNSCC cohort were evaluated for the predictive parameters that lead to CBS and survival rates with respect to different treatment regimes.…”

Section: Introductionmentioning

confidence: 99%

Chemoradiation and local recurrence of head and neck squamous cell carcinoma and the risk of carotid artery blowout

et al. 2019

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Background Carotid blowout syndrome (CBS) is a rare but life‐threatening complication of head and neck squamous cell carcinoma (HNSCC). Chemoradiation (CRT) may make CBS more likely, but so far no longitudinal analysis of different treatment strategies has been conducted. Methods In the present study, 1072 patients with HNSCC were divided into groups depending on whether they had experienced CBS. Disease‐related data were analyzed using chi‐square test, Fisher exact test, and Student's t test. Survival rates were calculated using Kaplan‐Meier test, log‐rank test, and the Cox regression analysis for forward selection. Results Thirty‐six patients suffering from CBS demonstrated significantly advanced T status (P = .001) and UICC stage (P = .004) when compared with unaltered counterparts. After adjustment for UICC stage, OS was comparable in both groups, whereas the mean recurrence‐free survival (RFS) rate was better in unaltered patients (67 vs 24 months; P < .0001). Cox regression for forward selection revealed local recurrence (hazard ratio [HR], 1.9; P < .0001), T status (HR, 1.9; P = .03), and CRT (HR, 2.0; P < .0001) as independent risk factors for mortality related to CBS. Conclusion CBS is a rare event in patients with HNSCC demonstrating reduced OS/RFS. Advanced T status, C/RT, and the recurrence of local tumors increase the risk of CBS‐associated death.

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“…Furthermore, significant side effects of current therapeutic strategies, including surgery and chemoradiotherapy, persist as important factors creating dissatisfaction with the treatment (3). Rare but life-threatening complications, such as vascular erosion after radiotherapy, have been described (4). However, in cases of advanced disease, even combined treatment modalities deliver unsatisfactory results (5).…”

Section: Introductionmentioning

confidence: 99%

Effect of thymoquinone on head and neck squamous cell carcinoma cells in vitro: Synergism with radiation

et al. 2017

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Abstract. Thymoquinone (TQ) is the main bioactive constituent present in black seed oil (Nigella sativa); it has shown anti-inflammatory and anti-neoplastic effects in various cancer cell types. The aim of the present study was to investigate the effects of TQ on head and neck squamous cell carcinoma (HNSCC) cell lines, on its own and in combination with radiation and cisplatin, respectively. The SCC25 and CAL27 HNSCC cell lines were treated with TQ alone and in combination with cisplatin or radiation, respectively. Proliferation assays and clonogenic assays were performed. Apoptosis was detected by flow cytometry. TQ exhibited dose-dependent cytotoxicity via apoptosis in the investigated cell lines. In combination with cisplatin, TQ resulted in no significant increase in cytotoxicity. Combined with radiation, TQ significantly reduced clonogenic survival compared with each treatment method alone. TQ is a promising agent in the treatment of head and neck cancer due to its anti-proliferative and radiosensitizing properties. However, the combination of TQ with cisplatin showed no therapeutic benefit in vitro.

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Acute Arterial Hemorrhage Following Radiotherapy of Oropharyngeal Squamous Cell Carcinoma

Cited by 19 publications

References 18 publications

Early death among head and neck cancer patients

Early death among head and neck cancer patients

Chemoradiation and local recurrence of head and neck squamous cell carcinoma and the risk of carotid artery blowout

Effect of thymoquinone on head and neck squamous cell carcinoma cells in vitro: Synergism with radiation

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