Acute Arthritis Associated With Loading Dose of Clopidogrel

Tayyareci, Yelda

doi:10.1097/rhu.0b013e31818272a6

Cited by 14 publications

(12 citation statements)

References 7 publications

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“…This thienopyridine is generally well‐tolerated, with an adverse‐effect profile similar to that of other antiplatelet agents. Of the three thienopyridines currently approved and available in the United States, only ticlopidine and clopidogrel have been associated with rare cases of acute arthritis . The lack of published reports of thienopyridine‐induced acute arthritis with prasugrel use may be due to the short amount of time this agent has been available on the U.S. market.…”

Section: Discussionmentioning

confidence: 99%

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Prasugrel as a Safe Alternative for Clopidogrel‐Induced Polyarthralgias

Coulter

Montandon

2012

Pharmacotherapy

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Clopidogrel is an oral thienopyridine that has been shown to reduce the risk of vascular death in patients with acute coronary syndrome, ischemic stroke, and peripheral vascular disease. The drug is associated with rare adverse effects such as thrombotic thrombocytopenia purpura, acute hepatotoxicity, and neutropenia. Only six cases have been reported that link acute arthritis with the use of clopidogrel. We describe a 64-year-old Caucasian man with sudden onset of severe arthritis, erythema, and swelling after starting clopidogrel therapy; he had no history of arthralgias while taking prasugrel during the previous 8 months. The patient was hospitalized for 3 days, and after cessation of clopidogrel therapy and conservative management, he improved dramatically, showing resolution of his joint erythema and swelling. The patient started prasugrel therapy at discharge, and no arthritic development was noted 8 weeks later. Although clopidogrel is commonly well tolerated, this case report demonstrates that clinicians should be aware that acute arthritis may be a possible adverse effect of clopidogrel. Additionally, polyarthralgias may not be a class effect of thienopyridines; patients who experience acute arthralgias during clopidogrel therapy may not experience similar adverse effects with prasugrel.

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Section: Discussionmentioning

confidence: 99%

“…Only seven case reports have documented thienopyridine-induced arthritis. [10][11][12][13][14][15]17 Of these, six involved clopidogrel and one ticlopidine. One of the cases of clopidogrel-induced arthritis reported ticlopidine as a successful alternative to clopidogrel.…”

Section: Clopidogrel-induced Polyarthralgias Coulter and Montandon E25mentioning

confidence: 99%

Prasugrel as a Safe Alternative for Clopidogrel‐Induced Polyarthralgias

Coulter

Montandon

2012

Pharmacotherapy

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“…Furthermore, it was shown that genetic depletion of COX-1 in mice resulted in an ameliorated disease course in an animal model of RA [53]. Even more surprising, treatment with P2Y 12 receptor antagonists like prasugrel leads to an aggravated disease course [70,73]; however, to support the potential human relevance, several case reports of patients developing spontaneous joint inflammation after clopidogrel intake exist [74,75,76,77,78,79]. Additionally, the effect of dipyridamole was tested as a therapy in RA patients, but it did not modify disease severity [80].…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

The Inflammatory Role of Platelets: Translational Insights from Experimental Studies of Autoimmune Disorders

Pankratz

Bittner

Kehrel

et al. 2016

IJMS

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Beyond their indispensable role in hemostasis, platelets have shown to affect the development of inflammatory disorders, as they have been epidemiologically and mechanistically linked to diseases featuring an inflammatory reaction in inflammatory diseases like multiple sclerosis, rheumatoid arthritis and inflammatory bowel disorders. The identification of novel molecular mechanisms linking inflammation and to platelets has highlighted them as new targets for therapeutic interventions. In particular, genetic and pharmacological studies have identified an important role for platelets in neuroinflammation. This review summarizes the main molecular links between platelets and inflammation, focusing on immune regulatory factors, receptors, cellular targets and signaling pathways by which they can amplify inflammatory reactions and that make them potential therapeutic targets.

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“…Although a small number of cases of clopidogrel-associated acute arthritis have been reported overseas [4][5][6][7][8], this is the Wrst such case reported in Japan. In the previous reports [4][5][6][7][8], the characteristics of clopidogrel-associated acute arthritis include (1) fever, (2) rash, (3) pruritis and (4) acute arthritis. These patients develop acute onset of polyarthritis 10-20 days after commencement of the drug.…”

Section: Discussionmentioning

confidence: 99%

Clopidogrel-associated acute arthritis

et al. 2009

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A 54-year-old Japanese man was urgently admitted to our hospital because of "unmovable" polyarthralgia, high fever and pruritus. He had taken clopidogrel 3 weeks before this admission to prevent ischemic cerebrovascular events. On the laboratory values, acute phase reactants and serum IgE were elevated. Although his symptoms had promptly improved with non-steroidal anti-inflammatory drugs (NSAIDs) and cessation of the drug, the same phenomena were re-induced by re-administration of the drug. According to the above manifestations, he was diagnosed as suffering from clopidogrel-associated acute arthritis.

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Acute Arthritis Associated With Loading Dose of Clopidogrel

Cited by 14 publications

References 7 publications

Prasugrel as a Safe Alternative for Clopidogrel‐Induced Polyarthralgias

Prasugrel as a Safe Alternative for Clopidogrel‐Induced Polyarthralgias

The Inflammatory Role of Platelets: Translational Insights from Experimental Studies of Autoimmune Disorders

Clopidogrel-associated acute arthritis

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