Acute bacterial meningitis in nigerian children beyond neonatal period: A review

Mado, Sani M; Aliyu, Ibrahim

doi:10.4103/njbcs.njbcs_26_17

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…The incidence is most signi icant in pediatric patients, especially infants, with attack rates in neonates at about 400 per 100,000, and 20 per 100,000 in those less than or equal to 2 years old. (Mado and Aliyu, 2018) In a multicentre survey in India, Acute Bacterial Meningitis constituted 1.5% of admissions in pediatric wards with a mean case fatality rate of16%. (Mace, 2008) Traumatic Brain Injury (TBI) is the most common cause of death and acquired disability among children and young adults in developed countries and, even when adequate treatment is provided, TBI commonly causes neuronal loss.…”

Section: Introductionmentioning

confidence: 99%

Role of serum osmolarity as an indicator for neurological morbidity in children with acute central nervous illness

Xavier¹

2020

ijrps

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Acute CNS illness comprising of Acute CNS infections along with Traumatic head Injury is an important cause for significant morbidity and mortality in Pediatric Intensive Care units across the world. Osmolar changes in the blood correlate well with CNS status. Acute BM is still a meaningful, host-pathogen interaction responsible for bacterial invasion of the CNS Osmolality in children with CNS illness is a good indicator of assessing neurological Morbidity and Mortality. A complex neuroendocrine system is involved in the maintenance of sodium and water homeostasis. Bacterial Meningitis (BM) is an acute purulent infection of the meninges. It is the most common bacterial infection of the CNS& it’s the medical emergency that still has high mortality and morbidity. Blood-Brain Barrier is relatively impermeable to sodium, but water crosses freely. Variety of result in sodium dysregulation such as Traumatic Brain Injury, pyogenic meningitis, viral encephalitis, which is associated with significant Mortality and Morbidity. The objective of our study is to determine the incidence and outcome of Serum Osmolar change in children presenting with acute neurological illness. A prospective observational study was carried out between Jan 6th2020-March 6 th2020 enrolling children between ages of 1 month to 15 years, admitted to the PICU of SMCH with Acute onset neurological illness. Among 40 children, 20 children with hyponatremia have 50% of neurological deficit, Children with hypernatremia 50% had Neurological deficit, which is not statistically significant at P value0.083. Among the 40 children 40% had low Osmolality, 25% have high Osmolality& 35% had normal range, which is not statistically significant at P value 0.199

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Section: Introductionmentioning

confidence: 99%

Role of serum osmolarity as an indicator for neurological morbidity in children with acute central nervous illness

Xavier¹

2020

ijrps

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Modeling the bacterial meningitis death cases and case fatality rates over Nigeria

Makinde

Omotosho

Fadugba

et al. 2021

Communications in Statistics: Case Studies, Data Analysis and A

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Drug resistance profiling, antimicrobial susceptibility and demographic characteristics of children with acute bacterial meningitis in a Southeastern tertiary health facility

Nwala,

Izuka,

Chidomere

et al. 2024

Int J Sci Rep

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Background: Over the years, varying patterns of bacterial susceptibility and multidrug resistance (MDR) rates have been reported in different settings. Detailed evaluation of the drug profile of the bacterial pathogens implicated in children with invasive bacterial infection helps to reduce the heightened risk of adverse events that could follow poorly managed or complicated cases in resource limited environment like ours. This study therefore, aimed to highlight the antibiotic susceptibility and MDR rate, and establish the relationship if any, between demographic characteristics and positive CSF- bacterial isolates of post neonatal children with suspected acute bacterial meningitis (ABM). The findings would guide practitioners on the empirical antimicrobials to consider in the event of clinical suspicion of ABM pending the availability of CSF isolates' antibiogram. Methods: A prospective review of 100 children with clinical suspicion of ABM from January 2016- December 2020. Descriptive statistics, chi square and regression analysis were used to establish MDR rates, Isolates' susceptibility pattern and the relationship between demographic variables and positive isolates respectively. P<0.05 was accepted as significant. Results: Fluroquinolones, cephalosporins, imipenem and aminoglycosides were susceptible anti-microgram in children with ABM. Sixty-four (85.5%) of the isolates showed MDR pattern, and young children (infants and toddlers) were significantly associated with positive CSF bacterial isolates. Conclusions: ABM should be treated with combination of CNS penetrating empirical antibiotics due to rising rate of MDR pathogens. Young children with febrile illnesses should be thoroughly evaluated for possibility of CNS infection.

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Acute bacterial meningitis in nigerian children beyond neonatal period: A review

Cited by 4 publications

References 9 publications

Role of serum osmolarity as an indicator for neurological morbidity in children with acute central nervous illness

Role of serum osmolarity as an indicator for neurological morbidity in children with acute central nervous illness

Modeling the bacterial meningitis death cases and case fatality rates over Nigeria

Drug resistance profiling, antimicrobial susceptibility and demographic characteristics of children with acute bacterial meningitis in a Southeastern tertiary health facility

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