Acute bacterial skin and soft tissue infections: new drugs in ID armamentarium

Tirupathi, Raghavendra; Areti, Swetha; Salim, Sohail Abdul; Palabindala, Venkatraman; Jonnalagadda, Nageshwar

doi:10.1080/20009666.2019.1651482

Cited by 11 publications

(5 citation statements)

References 11 publications

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“…These demonstrate a good relationship of respect and appreciation between patients and clinicians, including expectations, negotiations, consistent and supportive policies, and a standardized approach (23). It is also essential to implement shared decision-making strategies to resolve patients' discordant expectations and physicians' antibiotics prescribing practices (26) especially with newly approved antimicrobial agents with high cost in order to avoid the development of resistance (25).…”

Section: Discussionmentioning

confidence: 99%

Public Knowledge, Attitude and Practice towards Antibiotics Use and Antimicrobial Resistance in Saudi Arabia: A Web-Based Cross-Sectional Survey

Alnasser

Al‐Tawfiq

Ahmed³

et al. 2021

Journal of Public Health Research

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Background: Antimicrobial resistance is a global issue that causes significant morbidity and mortality. Therefore, this study aims to assess knowledge, attitudes, and practices (KAP) of the general Saudi populations toward antibiotics use.Design and methods: A cross-sectional, anonymous online survey was conducted from January 1 to May 11, 2020, across five major regions of Saudi Arabia. Participants (aged ≥18 years) were invited through social media to complete an online self-structured questionnaire. All data were analyzed by Statistical Package (SPSS v.25). Descriptive statistics, Pearson's Chi-squared, t-tests, one-way analysis of variance (ANOVA), and Pearson correlation analyses were conducted. Results: Out of 443 participants, the majority (n=309, 69.8%) were females, 294 (64.4%) were married, 176 (39.7%) were 25-34 years of age, 338 (76.3%) were living in the Eastern Province, 313 (70.7%) had college or higher education, 139 (31.4%) were not working, and 163 (36.8%) had a monthly income of USD 800-1330. Overall, most participants demonstrated good knowledge and practice (88% and 85.6%, respectively). However, 76.8%had inadequate attitude score levels towards antibiotics use. Of all the respondents, 74.9% knew that not completing a full course of antibiotics may cause antibiotics resistance, 91.33% did not agree that antibiotics should be accessed without a prescription, and 94.04% will not hand over leftover antibiotics to family members. Factors associated with adequate knowledge were female, medical jobs, and higher income (p<0.05). Conclusions: Our findings revealed that while most participants were aware of antibiotics use and demonstrated good knowledge, good practices, they had negative attitudes towards antibiotics use.

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Section: Discussionmentioning

confidence: 99%

Public Knowledge, Attitude and Practice towards Antibiotics Use and Antimicrobial Resistance in Saudi Arabia: A Web-Based Cross-Sectional Survey

Alnasser

Al‐Tawfiq

Ahmed³

et al. 2021

Journal of Public Health Research

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“…In addition to sitafloxacin, some newer fluoroquinolones, such as finafloxacin and delafloxacin, are under development to address the drug-resistant pathogens. Sitafloxacin and these promising fluoroquinolones will provide more alternative treatment options for managing UTIs in adults [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

A randomized, active-controlled, multicentre clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated or complicated urinary tract infection

Yin

Peng

et al. 2020

Annals of Medicine

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Purpose To evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated urinary tract infection (UTI) or complicated UTI. Methods In this randomized, active-controlled clinical trial, the patients with acute uncomplicated UTI were randomized to receive sitafloxacin 100-mg once-daily (qd) or levofloxacin 500-mg qd orally for 3–5 days. The patients with complicated UTI were randomized to receive sitafloxacin 100-mg twice daily or levofloxacin 500-mg qd orally for 10–14 days. The primary endpoint was the clinical efficacy at test-of-cure (TOC) visit. Results At TOC visit, the clinical cure rate was 89.2% (58/65) in sitafloxacin group and 97.1% (68/70) in levofloxacin group for the patients with acute uncomplicated UTI corresponding to the bacterial eradication rate of 97.1% (34/35) and 97.6% (41/42) (all p > .05), respectively. For the patients with complicated UTI, the clinical cure rate was 81.8% (27/33) in sitafloxacin group and 76.9% (20/26) in levofloxacin group corresponding to the bacterial eradication rate of 93.3% (14/15) and 63.6% (7/11) (all p > .05), respectively. Sitafloxacin and levofloxacin showed similar incidence of drug-related adverse events. Conclusions Oral sitafloxacin is as effective and safe as levofloxacin in treating acute uncomplicated and complicated UTI. KEY MESSAGE: Oral sitafloxacin showed similar clinical cure rate and bacterial eradication rate as levofloxacin for treatment of complicated and uncomplicated urinary tract infections (UTIs) in a randomized, active-controlled, multicentre clinical trial. Oral sitafloxacin is safe and well-tolerated in treating acute uncomplicated and complicated UTIs in Chinese adults. Sitafloxacin is a promising alternative treatment option for UTIs in adults.

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“…Delafloxacin drug 25 is a new member of the antibacterial fluoroquinolone family that received approval in the USA and become available in sixty eight countries located in Europe, Asia, Australia, and America [34]. The drug Delafloxacin was approved by FDA as medication for different pathogenic bacterial diseases such as acute bacterial skin, and skin structure infections (ABSSSI), Gram-positive and Gram-negative bacterial species, including (MRSA) subtype [35,36].…”

Section: Generations Of Quinolonesmentioning

confidence: 99%

Recent Strategies in Design of Antitumor and Antibacterial Fluoroquinolones

Samir

Ramadan

Hamed

et al. 2021

Journal of advanced Biomedical and Pharmaceutical Sciences

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Fluoroquinolones are known widely used synthetic antibacterial agents. Generally, there were some obstacles associated with their therapeutic use. Moreover, many research studies all over the world proved the variable biological effects of fluoroquinolones such as antituberculosis, anticancer, or even antiviral activities. The current review is focused on modifications that occurred in the fluoroquinolone scaffold for their repositioning from antibacterial into anticancer agents especially modifications at C-7 or at the carboxylic C-3 groups. In addition, it includes the recent research studies carried out to improve the potency, spectrum of activity, or pharmacokinetics of antibacterial fluoroquinolones. Hence, this review may be useful for researchers in the design and synthesis of new fluoroquinolones with improved biological activities.

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Acute bacterial skin and soft tissue infections: new drugs in ID armamentarium

Cited by 11 publications

References 11 publications

Public Knowledge, Attitude and Practice towards Antibiotics Use and Antimicrobial Resistance in Saudi Arabia: A Web-Based Cross-Sectional Survey

Public Knowledge, Attitude and Practice towards Antibiotics Use and Antimicrobial Resistance in Saudi Arabia: A Web-Based Cross-Sectional Survey

A randomized, active-controlled, multicentre clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated or complicated urinary tract infection

Recent Strategies in Design of Antitumor and Antibacterial Fluoroquinolones

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