Acute Basophilic Leukemia with t(8;21)

Abstract

Acute basophilic leukemia (ABL) is a rare form of leukemia. The diagnostic criteria have recently been described. Morphological evidence for basophilic lineage is required for its classification. However the criteria for remission status and standard therapy is not established. Here we have described an atypical case of ABL and reviewed the literature to high light issues regarding diagnosis and management, which need further discussion.

FLT-3 ITD Positive Acute Basophilic Leukemia with Rare Complex Karyotype Presenting with Acute Respiratory Failure: Case Report

“…Differential diagnosis includes other myeloid neoplasms associated with basophilia, namely AML with t(6;9)(p23;q14), acute promyelocytic leukemia with basophilic differentiation, blastic transformation of chronic myelogenous leukemia, primary myelofibrosis, or rare acute lymphoblastic leukemia cases with prominent cytoplasmic granules [1,4]. Noteworthy, even though multiple chromosomal abnormalities have been reported involving chromosomes 1, 2,6,7,8,11,12,16,17,19,21 and X, no recurrent cytogenetic or molecular anomalies have been described in acute basophilic leukemia patients [3,[5][6][7][8][9][10][11][12][13]. Acute basophilic leukemia management remains poorly defined, relying on cytarabine and anthracycline-based induction regimens, palliative cytoreductive treatment, targeted therapies (tyrosine kinase inhibitors) or allogeneic stem cell transplant in selected cases [7,14].…”

Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS‐ERG fusion gene

“…Recent findings suggest that IKAROS alterations are associated with disease acceleration and basophil expansion in CML . Basophilic differentiation may occur in AML carrying t(8;21)(q22;q22)/ RUNX1 ‐ RUNX1T1 ; however, reactive BM basophilia in response to a factor produced by leukemia blasts was suggested in one case . t(6;9)(p22;q34)/ DEK ‐ NUP214 is observed in AML with or without monocytic features and 44–62% of cases show >2% basophilia in PB and BM .…”

Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 homozygous polymorphisms

“…Cases of de novo AML with predominant basophilic and/or mastocytic, cell phenotypes are uncommon and they account for only 4-5% of all cases of acute nonlymphocytic leukemia [34,35]. Although acute basophilic leukemia (ABL) has been long diagnosed as such, current knowledge of this specific AML subtype remains limited [36]. …”