Acute Bilateral Renal and Splenic Infarctions Occurring during Chemotherapy for Lung Cancer

Abstract

We herein report a rare case of acute bilateral renal and splenic infarctions occurring during chemotherapy for lung cancer. A 60-year-old man presented with acute and intensive upper abdominal and back pain during chemotherapy with cisplatin and etoposide for lung cancer. Contrast-enhanced computed tomography (CT) revealed bilateral renal and splenic infarctions. After the administration of unfractionated heparin his pain was relieved with a clearance of the infarctions in the CT findings and a recovery of renal dysfunction. Enhanced coagulation by lung cancer and arterial ischemia by chemotherapy may therefore contribute to the development of these infarctions.

Metastatic Lung Cancer with Multiorgan Thrombosis and Budd–Chiari Syndrome: A Rare Case

“…In our case, ischaemia was found in the spleen and kidney, which are rarely affected locations [ 5 , 6 ] . There are few reports describing similar presentations of arterial thromboembolic phenomena associated with lung cancer [ 5 – 7 ] .…”

Chemical and Biological Evidence of the Efficacy of Shengxian Decoction for Treating Human Lung Adenocarcinoma

“…The effect of SXT on organ toxicity was also assessed by measuring organ indices (organ weight/body weight). We selected the spleen and lung as representative organs because their injuries frequently occur during chemotherapy (31,32). As shown in Figures 6B, C, neither spleen nor lung indices exhibited significant differences (P > 0.05) between the control and treated groups.…”