Acute Binge Alcohol Administration Reverses Sleep-Wake Cycle in Sprague Dawley Rats

Sharma, Rishi; Bradshaw, Kevin; Sahota, Pradeep; Thakkar, Mahesh

doi:10.1111/acer.12463

Cited by 14 publications

(11 citation statements)

References 34 publications

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“…There was a dose-response relationship between sleep problems and frequency of binge drinking, consistent with our study. In addition, Sharma et al 59 found that binge drinking could reverse sleep-wake cycle in rats and produce symptoms of insomnia, which could provide some explanation for the association between insomnia and binge drinking among students in the current study.…”

Section: Discussionsupporting

confidence: 54%

Binge drinking and associated factors among school students: a cross-sectional study in Zhejiang Province, China

Wang

Zhong

et al. 2018

BMJ Open

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ObjectiveTo investigate the prevalence and correlating factors of binge drinking among middle and high school students in Zhejiang Province, China.MethodsWe performed a cross-sectional study using data from a school-based survey. A total of 23 543 (response rate=97.5%) eligible adolescents from 442 different schools (including middle schools, academic high schools and vocational high schools) were asked to fill in an anonymous self-administered behaviour questionnaire between April and May 2017. Multivariable logistic regression models were used to examine the associations of sociodemographic and behavioural factors with binge drinking.ResultsThe mean (SD) age of participants was 15.6 (1.7) years and 51.3% were boys. The proportions of students from middle schools, academic high schools and vocational high schools were 51.9%, 27.5% and 20.6%, respectively. In total, 22.8% (95% CI 21.6 to 23.9) of students reported drinking alcohol in the past 30 days and 9.2% (95% CI 8.5 to 10.0) of students reported binge drinking (defined as drinking four or more alcoholic drinks in 1–2 hours period among girls and five or more alcoholic drinks among boys) during the past month. The prevalence of binge drinking was highest among vocational high school students (17.9% vs 6.3% and 7.7% among middle school and academic high school students, respectively). Older age, studying at high school, poor academic performance, higher levels of physical activity, excessive screen-time, loneliness, insomnia, previous suicide attempt, cigarette smoking, fighting, being bullied and sexual experience were found to be positively associated with adolescent binge drinking.ConclusionsBinge drinking is common among middle and high school students in Zhejiang, China. Efforts to prevent binge drinking may need to address a cluster of sociodemographic and behavioural factors. Our findings provide information to enable healthcare providers to identify students at high-risk of binge drinking and to inform planning of intervention measures for at-risk students.

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Section: Discussionsupporting

confidence: 54%

Binge drinking and associated factors among school students: a cross-sectional study in Zhejiang Province, China

Wang

Zhong

et al. 2018

BMJ Open

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“…Since BF and AD are key substrates involved in sleep homeostasis, we suggest that AD and BF may be critical in mediating alcohol-induced sleep. It is entirely possible that, along with AD and BF, alcohol may concurrently (directly or indirectly) inhibit multiple wake-promoting systems [for an example, see Sharma, Sahota, & Thakkar, 2014c] while activating sleep-promoting systems. More research is necessary to understand how and where alcohol acts to promote sleep and cause sleep disruptions.…”

Section: Discussionmentioning

confidence: 99%

“…We believe that this is the first step toward understanding the mechanism of sleep disruptions induced by binge drinking. Still, many questions remained unanswered such as a) how long do the effects of acute binge drinking on sleep homeostasis last, b) if sleep homeostasis is affected, does it play any role in reducing sleep-promoting effects of subsequent alcohol consumption which we have observed in our recent study (Sharma et al, 2014b), and c) what is the molecular mechanism responsible for altered sleep homeostasis?…”

Section: Sleep Homeostasis In Binge Alcohol-induced Sleep Disruptionsmentioning

confidence: 95%

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Alcohol disrupts sleep homeostasis

Thakkar

Sharma

Sahota

2015

Alcohol

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209

150

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Alcohol is a potent somnogen and one of the most commonly used “over the counter” sleep aids. In healthy non-alcoholics, acute alcohol decreases sleep latency, consolidates and increases the quality (delta power) and quantity of NREM sleep during the first half of the night. However, sleep is disrupted during the second half. Alcoholics, both during drinking periods and during abstinences, suffer from a multitude of sleep disruptions manifested by profound insomnia, excessive daytime sleepiness, and altered sleep architecture. Furthermore, subjective and objective indicators of sleep disturbances are predictors of relapse. Finally, within the USA, it is estimated that societal costs of alcohol-related sleep disorders exceeds $18 billion. Thus, although alcohol-associated sleep problems have significant economic and clinical consequences, very little is known about how and where alcohol acts to affect sleep. In this review, we have described our attempts to understand how and where alcohol acts to affect sleep. We have conducted a series of experiments using two different species, rats and mice, as animal models, and a combination of multi-disciplinary experimental methodologies to examine and understand anatomical and cellular substrates mediating the effects of acute and chronic alcohol exposure on sleep-wakefulness. The results of our studies suggest that the sleep-promoting effects of alcohol may be mediated via alcohol’s action on the mediators of sleep homeostasis: adenosine (AD) and the wake-promoting cholinergic neurons of the basal forebrain (BF). Alcohol, via its action on AD uptake, increases extracellular AD resulting in the inhibition of BF wake-promoting neurons. Lesions of the BF cholinergic neurons or blockade of AD A1 receptors results in attenuation of alcohol-induced sleep promotion, suggesting that AD and BF cholinergic neurons are critical for sleep-promoting effects of alcohol. Since binge alcohol consumption is a highly prevalent pattern of alcohol consumption and disrupts sleep, we examined the effects of binge drinking on sleep-wakefulness. Our results suggest that disrupted sleep homeostasis may be the primary cause of sleep disruption observed following binge drinking. Finally, we have also shown that insomnia and associated sleep disruptions, observed during acute withdrawal, are caused due to impaired sleep homeostasis. Based on our findings, we suggest that alcohol may disrupt sleep homeostasis to cause sleep disruptions.

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“…The percent time spent in each state was grouped into two 3 h bins and used for further analysis. Sleep onset latency [amount of time in minutes between alcohol administration and first non-interrupted 60 s bout of NREM sleep; see (Thakkar et al 2010b)], bout frequency, and average duration of each bout (for all three states) were also determined (Sharma et al 2014b). Spectral analysis was also performed to examine NREM delta power (1-4 Hz).…”

Section: Sleep/wake Recording and Analysismentioning

confidence: 99%

Nicotine administration in the wake‐promoting basal forebrain attenuates sleep‐promoting effects of alcohol

Sharma

Lodhi

Sahota

et al. 2015

Journal of Neurochemistry

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Nicotine and alcohol co-abuse is highly prevalent, although the underlying causes are unclear. It has been suggested that nicotine enhances pleasurable effects of alcohol while reducing aversive effects. Recently, we reported that nicotine acts via the basal forebrain (BF) to activate nucleus accumbens and increase alcohol consumption. Does nicotine suppress alcoholinduced aversive effects via the BF? We hypothesized that nicotine may act via the BF to suppress sleep-promoting effects of alcohol. To test this hypothesis, adult male Sprague-Dawley rats were implanted with sleep-recording electrodes and bilateral guides targeted toward the BF. Nicotine (75 pmol/ 500 nL/side) or artificial cerebrospinal fluid (ACSF; 500 nL/ side) was microinjected into the BF followed by intragastric alcohol (ACSF + EtOH and NiC + EtOH groups; 3 g/kg) or water (NiC + W and ACSF + W groups; 10 mL/kg) administration. On completion, rats were killed and processed to localize injection sites in the BF. The statistical analysis revealed a significant effect of treatment on sleep-wakefulness. While rats exposed to alcohol (ACSF + EtOH) displayed strong sleep promotion, nicotine pre-treatment in the BF (NiC + EtOH) attenuated alcohol-induced sleep and normalized sleep-wakefulness. These results suggest that nicotine acts via the BF to suppress the aversive, sleep-promoting effects of alcohol, further supporting the role of BF in alcohol-nicotine co-use.

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Acute Binge Alcohol Administration Reverses Sleep-Wake Cycle in Sprague Dawley Rats

Cited by 14 publications

References 34 publications

Binge drinking and associated factors among school students: a cross-sectional study in Zhejiang Province, China

Binge drinking and associated factors among school students: a cross-sectional study in Zhejiang Province, China

Alcohol disrupts sleep homeostasis

Nicotine administration in the wake‐promoting basal forebrain attenuates sleep‐promoting effects of alcohol

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