Acute Caffeine Ingestion: Clinical Features in Patients Attending the Emergency Department and Scottish Poison Centre Enquiries Between 2000 and 2008

Waring, W. Stephen; Laing, W. J.; Good, Anthony; Malkowska, A. M.

doi:10.1258/rsmsmj.54.4.3

Cited by 13 publications

(13 citation statements)

References 27 publications

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“…The recreational abuse of caffeine seems to vary by region; a recent report from Scotland suggests that the abuse has remained constant over recent years. 2 Whereas a report from United States considers a rising occurrence of caffeine abuse and regards any attempt to prevent abuse as very difficult. 3 Numerous toxic effects of caffeine have been described.…”

Section: Introductionmentioning

confidence: 99%

Caffeine fatalities – Do sales restrictions prevent intentional intoxications?

Thelander

Jönsson

Personne

et al. 2010

Clinical Toxicology

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Section: Introductionmentioning

confidence: 99%

Caffeine fatalities – Do sales restrictions prevent intentional intoxications?

Thelander

Jönsson

Personne

et al. 2010

Clinical Toxicology

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“…[41] Caffeine can, potentially, cause significant acute toxicity, [42] and there is the potential that the caffeine found in products containing DMAA may contribute to the toxicity associated with their use. [41] Caffeine can, potentially, cause significant acute toxicity, [42] and there is the potential that the caffeine found in products containing DMAA may contribute to the toxicity associated with their use.…”

Section: Discussionmentioning

confidence: 99%

Running an unknown risk: a marathon death associated with the use of 1,3‐dimethylamylamine (DMAA)

Archer

Dargan

Lostia

et al. 2015

Drug Testing and Analysis

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“…Ingestion of large amounts of caffeine can cause significant agitation, severe hypotension, tachycardia, ventricular arrhythmia, cardiac arrest, myocardial infarction, hypokalemia, rhabdomyolysis, seizures and acute renal impairment 8,9 . Waring et al 10 showed clinical data of 38 patients with caffeine ingested at an average dose of 1,040 mg (600 to 1,500 mg), which is equivalent to the amount found in about 10 cups of coffee. Out of them, 28 (73.7%) patients attempted suicide by deliberate self-poisoning, 8 (21.1%) patients ingested caffeine in order to enjoy (energy drinks), and 2 (5.3%) patients did it for weight loss.…”

Section: Discussionmentioning

confidence: 99%

“…The presented patient was anxious upon admission, and later complained of a headache. According to the Scottish Poison Centre (for the period 2000 -2008) dizziness, headache, tremor and agitation were much less common symptoms of caffeine poisoning in comparison to those with gastrointestinal symptoms 10 .…”

Section: Discussionmentioning

confidence: 99%

Severe acute caffeine poisoning due to intradermal injections: Mesotherapy hazard

Vukčević

Stanković-Babić

Šegrt

et al. 2012

VSP

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Introduction. Caffeine is indicated in the treatment of migraine headaches, as well as neonatal apnea and bradycardia syndrome. In mild poisoning, the most prevalent symptoms are nausea, vomiting, diarrhea, tremor, anxiety and headache. In more severe cases, symptoms consist of heart rythym abnormalities, myocardial infarction and seizures. Due to its common lipolytic effect, caffeine is used in mesotherapy, usually in combination with drugs of similar effect. We presented a patient with acute iatrogenic caffeine poisoning. Case report. A 51-year-old woman, with preexisting hypertension and hypertensive cardiomyopathy was subjected to cosmetic treatment in order to remove fat by intradermal caffeine injections. During the treatment the patient felt sickness, an urge to vomit, and a pronounced deterioration of general condition. Upon examination, the patient exhibited somnolence, hypotension and nonsustained ventricular tachycardia, which was sufficient enough evidence for further hospitalization. On admission to the intensive care unit the patient was anxious with increased heart rate, normotensive, with cold, damp skin, and visible traces of injection sites with surrounding hematomas on the anterior abdominal wall. Paroxysmal supraventricular tachycardia (PSVT) on electrocardiographic monitoring was found. The laboratory analysis determined a lowered potassium level of 2.1 mmol/L (normal range 3,5 - 5.2 mmol/L), and a toxicological analysis (liquid chromatography with ultraviolet detection) proved a toxic concentration of caffeine in plasma - 85.03 mg/L (toxic concentration over 25 mg/L). On application of intensive therapy, antiarrhythmics, and substitution of potassium, as well as both symptomatic and supportive therapy, there was a significant recovery. The patient was discharged without any sequele within four days. Conclusion. A presented rare iatrogenic acute caffeine poisoning occured due to massive absorption of caffeine from the subcutaneous adipose tissue into the circulation when injected directly into the tiny blood vessels, as evidenced by hematoma formation. Poisoning manifestations were registered in gastrointestinal, CNS (anxiety, somnolence) and cardiovascular (hypotension, ventricular tachycardia and nonsustained PSVT) system. In this era of mesotherapeutic treatment promotion, one should keep in mind toxic prevention, with application being carried out exclusively in a specialized institutio

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Acute Caffeine Ingestion: Clinical Features in Patients Attending the Emergency Department and Scottish Poison Centre Enquiries Between 2000 and 2008

Abstract: Caffeine ingestion is uncommon, and results in only a small number of hospital attendances and Poisons Centre enquiries. In contrast to patterns reported elsewhere, the prevalence of caffeine abuse has not increased in Scotland over recent years.

Cited by 13 publications

References 27 publications

Caffeine fatalities – Do sales restrictions prevent intentional intoxications?

Caffeine fatalities – Do sales restrictions prevent intentional intoxications?

Running an unknown risk: a marathon death associated with the use of 1,3‐dimethylamylamine (DMAA)

Severe acute caffeine poisoning due to intradermal injections: Mesotherapy hazard

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