Acute cardiac events in severe community‐acquired pneumonia: A multicenter study

Abstract

Our findings demonstrated that acute cardiac events are seen in a substantial proportion of patients with severe CAP and their occurence significantly associated with in-hospital mortality.

Cardiovascular Events after Community-Acquired Pneumonia: A Global Perspective with Systematic Review and Meta-Analysis of Observational Studies

“…Twelve studies provided data on inpatients [31,39,40,[46][47][48]54,56,58,59,64], four on low-risk inpatients [45,55,57,61] and five on high-risk inpatients [35,55,57,61,63]. Pooled event rates were 13.9% (95% confidence interval (CI) 9.6-18.9), 5.7% (95% CI 3.1-9.0) and 15.6% (95% CI 6.1-28.4), respectively ( Figure 2).…”

“…Cangemi et al [66] 2019 Italy Prospective single center Inpatients 545 ----9.5 a Cardiovascular (CV) events: congestive heart failure, atrial fibrillation, severe angina or myocardial infarction or stroke [31]; acute coronary or ventricular insufficiency [35]; cardiovascular complications likely to necessitate continued hospitalization [39]; cardiac complications without further specification [40]; acute coronary syndrome and/or heart failure [45]; myocardial infarction, angina pectoris, revascularization by angioplasty/coronary artery bypass graft (CABG) or death secondary to coronary heart disease, cerebrovascular accident, congestive heart insufficiency or claudication [46]; myocardial infarction, atrial fibrillation or ventricular tachycardia or incident heart failure [47]; myocardial infarction, atrial fibrillation, congestive heart failure or stroke [48]; new or worsening heart failure, new or worsening arrhythmias or myocardial infarction [54]; new-onset or worsening cardiac arrhythmias, new-onset or worsening congestive heart failure or myocardial infarction [55]; acute pulmonary edema, new onset cardiac arrhythmia, exacerbation of a preexisting arrhythmia, or myocardial infarction [56]; acute myocardial infarction, acute cardiogenic pulmonary edema, new arrhythmia, acute worsening of a long-term arrhythmia, cerebrovascular accident or pulmonary embolism [57];cardiovascular death, non-fatal myocardial infarction or stroke [58]; non-ST elevation myocardial infarction or ST elevation myocardial infarction, stroke, new episode of atrial fibrillation or deep venous thrombosis and/or pulmonary embolism, new or worsening HF or cardiovascular death [61] new onset or worsening arrhythmia, new onset or worsening heart failure or myocardial infarction [63]: new or worsening arrhythmia, heart failure or myocardial ischemia [64]. b Acute coronary syndromes (ACS): myocardial infarction [33,37,39,[47][48][49][53][54][55][56][57][58]…”

“…Thirteen studies reported data on inpatients [48][49][50][51][52][53][54][55][56]58,60,61,64], two on low-risk patients [44,57] and high-risk [57,63] patients and one on outpatients [54]. Pooled event rates were 4.5% (95% CI 2.9-6.5), 0.2 (95% CI 0-0.7), 1.6 (95% CI 0.1-4.9), and 0.9 (95% CI 0.5-1.8), respectively ( Figure 3).…”

“…Sixteen studies included inpatients [29,30,[36][37][38]47,48,50,[53][54][55][56][57]61,62,64], three focused on lowrisk patients [41,42,44], two focused on high-risk patients [43,63], and two on outpatients [54,62]. Pooled event rates were 9.2% (95% CI 6.7-12.2), 5.6% (95% CI 1.5-11.9), 11.1% (95% CI% 0-39), and 1.0% (95% CI 0.6-1.6), respectively ( Figure 4).…”

“…Incident arrhythmias were mentioned in twenty studies. Seventeen studies analysed inpatients [28,32,34,47,48,50,[52][53][54][55][56][57][58]61,[64][65][66], two focused on high-risk inpatients [43,63] and one on outpatients [54]. Pooled event rates were 7.2% (95% CI 5.6-9.0), 12.7% (95% CI 9.8-15.8), and 0.7% (95% CI 0.3-1.5), respectively ( Figure 5).…”