Acute Cardiac Injury in COVID-19: A Systematic Review and Meta-analysis

Vakhshoori, Mehrbod; Heidarpour, Maryam; Shafie, Davood; Taheri, Marzieh; Rezaei, Nima; Sarrafzadegan, Nizal

doi:10.34172/aim.2020.107

Cited by 29 publications

(38 citation statements)

References 35 publications

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“…COVID-19 can affect multiple organs and systems [3][4][5][6][7][8][9][10][11], although it mainly involves the respiratory system, where its involvement can cause a wide range of symptoms from a common cold to severe respiratory distress [12][13][14][15]. In particular, the disease is more severe and deadly in older age groups and people who have pre-existing comorbidity.…”

Section: Introductionmentioning

confidence: 99%

A systematic review of pregnant women with COVID-19 and their neonates

Mirbeyk

Saghazadeh

Rezaei

2021

Arch Gynecol Obstet

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113

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Background In December 2019, a novel coronavirus disease (COVID-19) emerged in Wuhan, China, with an incredible contagion rate. However, the vertical transmission of COVID-19 is uncertain. Objectives This is a systematic review of published studies concerning pregnant women with confirmed COVID-19 and their neonates. Search strategy We carried out a systematic search in multiple databases, including PubMed, Web of Science, Google Scholar, Scopus, and WHO COVID-19 database using the following keywords: (Coronavirus) OR (novel coronavirus) OR (COVID-19) OR (COVID19) OR (COVID 19) OR (SARS-CoV2) OR (2019-nCoV)) and ((pregnancy) OR (pregnant) OR (vertical transmission) OR (neonate) OR (newborn) OR (placenta) OR (fetus) OR (Fetal)). The search took place in April 2020. Selection criteria Original articles published in English were eligible if they included pregnant patients infected with COVID-19 and their newborns. Data collection and analyses The outcomes of interest consisted of clinical manifestations of COVID-19 in pregnant patients with COVID-19 and also the effect of COVID-19 on neonatal and pregnancy outcomes. Main results 37 articles involving 364 pregnant women with COVID-19 and 302 neonates were included. The vast majority of pregnant patients were in their third trimester of pregnancy, and only 45 cases were in the first or second trimester (12.4%). Most mothers described mild to moderate manifestations of COVID-19. Of 364 pregnant women, 25 were asymptomatic at the time of admission. The most common symptoms were fever (62.4%) and cough (45.3%). Two maternal deaths occurred. Some pregnant patients (12.1%) had a negative SARS-CoV-2 test but displayed clinical manifestations and abnormalities in computed tomography (CT) scan related to COVID-19. Twenty-two (6.0%) pregnant patients developed severe pneumonia. Two maternal deaths occurred from severe pneumonia and multiple organ dysfunction. Studies included a total of 302 neonates from mothers with COVID-19. Of the studies that provided data on the timing of birth, there were 65 (23.6%) preterm neonates. One baby was born dead from a mother who also died from COVID-19. Of the babies born alive from mothers with COVID-19, five newborns faced critical conditions, and two later died. A total of 219 neonates underwent nasopharyngeal specimen collection for SARS-CoV-2, of which 11 tested positive (5%). Seventeen studies examined samples of the placenta, breast milk, umbilical cord, and amniotic fluid, and all tested negative except one amniotic fluid sample. Conclusions A systematic review of published studies confirm that the course of COVID-19 in pregnant women resembles that of other populations. However, there is not sufficient evidence to establish an idea that COVID-19 would not complicate pregnancy.

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Section: Introductionmentioning

confidence: 99%

A systematic review of pregnant women with COVID-19 and their neonates

Mirbeyk

Saghazadeh

Rezaei

2021

Arch Gynecol Obstet

Self Cite

113

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“…The disease, which first manifested itself as a respiratory viral infection of adults, is now known for its potential to affect both adults and children and involve multiple vital systems at the same time. [71][72][73][74][75][76][77][78][79][80][81][82][83] It may trigger hyperinflammation, causing immune responses to dysregulation. 54,74,76,77,79,81,[84][85][86][87][88][89][90][91][92][93][94][95][96][97][98][99][100][101] Antibody response occurs in response to COVID-19 and can help with the diagnosis of infection and reinfection.…”

Section: Discussionmentioning

confidence: 99%

Health Care Policies and COVID-19 Prevalence: Is There Any Association?

2021

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The coronavirus disease 2019 (COVID-19) pandemic has affected almost all countries and territories. As of December 6, 2020, the United States of America and India have the highest prevalence. Each country has implemented different strategies to control and reduce the spread of disease. Here, the association between prevalence number and health policies is evaluated by comparing 2 groups of countries: (1) Italy, the United States of America, Germany, Spain, and India with a higher prevalence than a linear trend line; and (2) Singapore and China with a lower or equal prevalence than linear forecasts. A rapid overview revealed that many countries have similar strategies for controlling COVID-19, including the suspension of air travel, the lockdown on the cities with the most cases detected, active case findings, monitoring of close contacts, and raising public awareness. Also, they used a gradual and phased plan to reopen activities. So, the difference between countries in the burden of COVID-19 can be attributable to the strict mode and nonstrict mode of implementation of strategies. Limitations at the national levels call for systemic rather than regional strategies.

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“…Risk factors for cardiovascular complications in SARS-CoV-2 infection that increase stroke risk are shown in Figures 1-6. The incidence of acute cardiac injury was reported 15% by a meta-analysis of patients with COVID-19 (165). Among 138 hospitalized patients with SARS-CoV-2 infection, cardiovascular complications such as acute cardiac injury (7%) and arrhythmia (16.7%) were more prevalent in patients who required ICU admission (166).…”

Section: Cardiovascular Complicationsmentioning

confidence: 99%

Stroke in SARS-CoV-2 Infection: A Pictorial Overview of the Pathoetiology

Neshin

Shahjouei

Koza

et al. 2021

Front. Cardiovasc. Med.

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Since the early days of the pandemic, there have been several reports of cerebrovascular complications during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Numerous studies proposed a role for SARS-CoV-2 in igniting stroke. In this review, we focused on the pathoetiology of stroke among the infected patients. We pictured the results of the SARS-CoV-2 invasion to the central nervous system (CNS) via neuronal and hematogenous routes, in addition to viral infection in peripheral tissues with extensive crosstalk with the CNS. SARS-CoV-2 infection results in pro-inflammatory cytokine and chemokine release and activation of the immune system, COVID-19-associated coagulopathy, endotheliitis and vasculitis, hypoxia, imbalance in the renin-angiotensin system, and cardiovascular complications that all may lead to the incidence of stroke. Critically ill patients, those with pre-existing comorbidities and patients taking certain medications, such as drugs with elevated risk for arrhythmia or thrombophilia, are more susceptible to a stroke after SARS-CoV-2 infection. By providing a pictorial narrative review, we illustrated these associations in detail to broaden the scope of our understanding of stroke in SARS-CoV-2-infected patients. We also discussed the role of antiplatelets and anticoagulants for stroke prevention and the need for a personalized approach among patients with SARS-CoV-2 infection.

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Acute Cardiac Injury in COVID-19: A Systematic Review and Meta-analysis

Cited by 29 publications

References 35 publications

A systematic review of pregnant women with COVID-19 and their neonates

A systematic review of pregnant women with COVID-19 and their neonates

Health Care Policies and COVID-19 Prevalence: Is There Any Association?

Stroke in SARS-CoV-2 Infection: A Pictorial Overview of the Pathoetiology

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