Acute cerebellitis requiring posterior fossa decompression after COVID-19 vaccination in an ocrelizumab-treated patient with multiple sclerosis

Acute cerebellitis following COVID‐19 vaccination: A case report

“…None of these three cases had a history of immunodeficiency and none had a progressive course. However, our case like the case by Gregor Brecl Jakob et al had a fulminant and deteriorative course which was treatment resistant 10 …”

“…Her CD-19/20 lymphocyte counts were zero, which could have caused some level of immune dysregulation. 10 In analyzing our case, two factors should be considered. First, the case shows close temporal association with COVID-19 vaccination that can suggest possible causality.…”

“…There have been various reports on extrapulmonary involvements of COVID‐19 vaccines, like stroke, GBS, Bell's palsy, and TM 3–5 . One case of acute cerebellitis after COVID‐19 vaccination has been reported in a multiple sclerosis (MS) patient using ocrelizumab 10 . Moreover, there are few reports on acute cerebellitis after COVID‐19 infection 11–13 .…”

“…Brain MRI showed diffuse cytotoxic edema of cerebellar cortex with restriction of diffusion sparing deep white matter and brainstem. Her CD‐19/20 lymphocyte counts were zero, which could have caused some level of immune dysregulation 10 …”

Post‐COVID vaccination Guillain–Barre syndrome

“…BBE, cerebellitis and lower cranial nerve involvement have been reported as a complication of SARS-CoV-2 vaccination. [3][4][5] The patient relapsed 8 weeks after onset. 1 We should know if chronic inflammatory demyelinating polyneuropathy (CIDP) was being considered and if the patient met the diagnostic criteria for CIDP.…”