Acute Cervical Myelopathy Following Laughing Gas Abuse

Lee, Hak-Loh; Lee, Seung-Jin; Nam, Taewoo; Min, Seung Hyun; Kim, Jae‐Myung; Kang, K.-D.

doi:10.4068/cmj.2019.55.2.118

Chonnam Med J

2019

DOI: 10.4068/cmj.2019.55.2.118

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Acute Cervical Myelopathy Following Laughing Gas Abuse

Hak-Loh Lee

Seung-Jin Lee

Taewoo Nam

et al.

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2021

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“…One patient presented with incidental PTE and lung infarction. Table3summarizes the details of the published cases 5,9,10. DISCUSSION N 2 O is known to selectively oxidize folate and vitamin B 12 , rendering them inactive and unable to degrade homocysteine into methionine, which is required for normal myelin production 11.…”

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confidence: 99%

Spectrum of nitrous oxide intoxication related neurological disorders in Korea: a case series and literature review

Lee¹,

Park²,

Kim³

et al. 2021

ACN

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Background: Nitrous oxide (N2O) is used in surgery and dentistry for its anesthetic and analgesic effects. However, neurological and psychiatric manifestations of N2O abuse have been increasingly reported among Korean adults. The aim of this study was to demonstrate laboratory findings of N2O abuse in Korean patients.Methods: Patients diagnosed with N2O-induced neuropathy or myelopathy from August 2018 to December 2019 were enrolled. Their clinical presentations and laboratory and imaging findings were analyzed.Results: Sensory changes and limb weakness were present in nine of the enrolled patients. The laboratory findings revealed that seven patients had high homocysteine levels and five had high methylmalonic acid levels in their blood. Nerve conductions studies indicated that axonal neuropathy was present in four cases and longer F-wave and Hoffman’s-reflex latencies were present in two cases. Signal changes in cervical spine imaging occurred in five patients, while two had normal results.Conclusions: Chronic N2O abuse can cause neurological damage or psychiatric problems. Because N2O is illegal for recreational use in Korea, patients tend to hide their history of use. Even though the spinal imaging results were normal, clinicians should consider the possibility of N2O use, and further electrophysiological tests should be applied for precise evaluations.

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confidence: 99%

Spectrum of nitrous oxide intoxication related neurological disorders in Korea: a case series and literature review

Lee¹,

Park²,

Kim³

et al. 2021

ACN

View full text Add to dashboard Cite

show abstract

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Acute Cervical Myelopathy Following Laughing Gas Abuse

Cited by 1 publication

References 3 publications

Spectrum of nitrous oxide intoxication related neurological disorders in Korea: a case series and literature review

Spectrum of nitrous oxide intoxication related neurological disorders in Korea: a case series and literature review

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