Acute Changes in Renal Size in Normal and Hypertensive Dogs

Shultz, Martin Lee

doi:10.1016/s0022-5347(17)61797-x

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…Although no significant interobserver difference was reported in CT-GFR determination (5), CT is nonetheless susceptible to volume averaging and motion artifacts that blur renal margins and the operator's ability to recognize and trace object boundaries (30). Intravenous administration of iodinated ionic and non-ionic contrast medium also increases renal size (31,32). Conversely, water displacement volume determination includes the renal pelvis, which accounts for approximately 4% of renal volume (29).…”

Section: Discussionmentioning

confidence: 99%

Patlak plot analysis CT‐GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs

Alexander

Authier

Castillo

et al. 2010

Contrast Media & Molecular

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Glomerular filtration rate (GFR) can be determined using Patlak plot analysis with single-slice dynamic computed tomography (CT). Acute autologous graft failure has several causes, all of which induce a measurable decrease in glomerular filtration rate. This study demonstrated in an experimental model of canine autologous renal transplant that CT-derived renal plasma clearance was significantly lower (p = 0.002) in dogs having undergone transplant (0.077 +/- 0.058 ml min(-1) ml renal tissue(-1)) compared with control dogs (0.396 +/- 0.139 ml min(-1) ml renal tissue(-1)). A significant negative curvilinear relationship was seen between serum creatinine and total renal plasma clearance (R(2) = 0.84, p = 0.0001). Alterations in renal time attenuation curve shape in dogs having undergone transplant may have been related to increased renal vascular resistance related to tubular necrosis. CT-GFR may be a useful experimental tool in the evaluation of renal dysfunction in transplant models.

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Section: Discussionmentioning

confidence: 99%

Patlak plot analysis CT‐GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs

Alexander

Authier

Castillo

et al. 2010

Contrast Media & Molecular

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“…In 8 out of the 11 patients with renovascular hypertension the difference in response between the paired kidneys had values outside the ranges of patients with both the other forms of arterial hypertension. The data suggest that the furosemide test may be of value in the screening for renovascular hypertension.Starting with Cohnheim and Roy's [ 1 ] observations in 1883, a series of studies on animals established that kidney vol ume increases when diuresis is provoked by various means [2][3][4]. This knowledge became clinically meaningful when it was observed that the intravenous administration of a loop diuretic in the course of urographic examination causes bilateral renal swelling in patients with essential hypertension, whereas in patients with unilateral renal artery stenosis such an effect is blunted on the affected side [5], On the basis of these observations, some authors pro posed the use of the so-called 'diuretic augmented excretory urography' as an improved method for the screening of renovascular hypertension [5][6][7].…”

mentioning

confidence: 99%

“…As to the latter possibility, it has been shown that the administration of the contrast agent causes some enlargement of the kidney [3,9], which might well interfere with the effect of the loop diuretic on kidney size. We thought that the use of a technic that does not involve the administration of an iodinated agent to record the variations in kidney size would help in settling the issue.…”

mentioning

confidence: 99%

Effect of Furosemide on Renal Size: Ultrasonic Characterization of Renovascular Hypertension

Maggiore¹,

Curatola²,

Zoccali³

1982

Nephron

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In this pilot study, sequential ultrasonic scanning was used to assess (a) whether furosemide injection normally causes an enlargement of kidney size, and (b) whether this effect is blunted in renovascular hypertensives to such a degree as to bear potential diagnostic value. Furosemide caused similar degrees of maximal area enlargement in both kidneys of 10 healthy subjects (16.1 ± 3.9%) and 10 essential hypertensives (14.8 ± 4.2%) whereas in 11 renovascular patients maximal distension of the affected kidneys was significantly blunted (9.4 ± 3.7%) in comparison with that of contralateral kidneys (19.6 ± 7.7%). In the 6 hypertensives with one small kidney not due to renal artery stenosis, maximal enlargement of the affected kidneys averaged 22.8 ± 5.1%, and that of contralateral kidneys 15.8 ± 4.2%. In 8 out of the 11 patients with renovascular hypertension the difference in response between the paired kidneys had values outside the ranges of patients with both the other forms of arterial hypertension. The data suggest that the furosemide test may be of value in the screening for renovascular hypertension.

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Computed tomography-derived intrarenal blood flow in renovascular and essential hypertension

Lerman

Taler

Textor

et al. 1996

Kidney International

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The effect of renal artery stenosis on intrarenal perfusion and volume in renovascular hypertensive patients is unclear. Alterations in these attributes may ultimately be involved in deterioration of renal function. We measured whole kidney, cortical, and medullary perfusion and volume with electron beam computed tomography (EBCT) in 33 hypertensive patients, with well-preserved renal function, scheduled for renal angiography. EBCT-derived whole kidney perfusion was lower in patients with atherosclerotic renal artery stenosis (RAS; N = 20) than in fibromuscular dysplasia (FMD; N = 10) or essential hypertension (N = 28; P < 0.05), as was cortical perfusion (2.44 +/- 0.16 vs. 3.26 +/- 0.17 and 3.07 +/- 0.09 ml/min/cc tissue, respectively, P < 0.005), but medullary perfusion was similar. Whole kidney, cortical, and medullary perfusion correlated inversely with degree of stenosis in FMD, but not in atherosclerotic RAS. Renal volumes were similar. These results demonstrate that, in contrast to patients with FMD, in patients with atherosclerotic RAS the decrease in cortical perfusion is not directly related to the degree of stenosis in the main renal artery. Factors other than the stenosis itself may play a role in the pathophysiology of atherosclerotic RAS and associated renal failure.

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Acute Changes in Renal Size in Normal and Hypertensive Dogs

Cited by 9 publications

References 5 publications

Patlak plot analysis CT‐GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs

Patlak plot analysis CT‐GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs

Effect of Furosemide on Renal Size: Ultrasonic Characterization of Renovascular Hypertension

Computed tomography-derived intrarenal blood flow in renovascular and essential hypertension

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