Acute Chest Pain as an Infusion Reaction to Vedolizumab

Abstract

Vedolizumab-associated adverse effects, including infusion reactions, are generally uncommon. Less than 5% of patients experience an infusion-related reaction. We report a 67-year-old male with ulcerative colitis under prolonged maintenance therapy who presented with recurring chest pain occurring immediately after consecutive vedolizumab infusions. Medical workup of possible etiologies for chest pain were investigated and excluded. Vedolizumab drug trough levels were negative, accompanied by high detectable levels of anti-vedolizumab antibodies. These findings demonstrate an uncommon case of an infusion reaction to vedolizumab infusion.

Reply to Daungsupawong and Wiwanitkit

“…I agree with the limitations you have pointed out, keeping in mind that this study is intended as a proof of concept for a novel feature of large language models (LLMs). Although 60 scenarios is not a large sample size, most similar studies in the field of gastroenterology and LLMs studied a similar number of scenarios [3,4,5]. The issue of interrogation of discrepancies as part of a systemic approach to the development and training of LLMs should indeed be further implemented and improved.…”