Acute Chlamydia pneumoniae infection in the pathogenesis of autoimmune diseases

Fujita, Masaaki; Hatachi, Saori; Yagita, Masato

doi:10.1177/0961203308096069

Cited by 25 publications

(22 citation statements)

References 19 publications

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“…pneumoniae IgM positive cases were more frequent among the patients with rheumatoid arthritis , systemic lupus erythematosus, dermatomyositis/polymyositis , myeloperoxidaseantineutrophil cytoplasmic autoantibody -associated vasculitis , adult onset of Still's disease and giant cell arteritis/Takayasu arteritis than among the controls [24].…”

Section: Multiple Sclerosismentioning

confidence: 93%

“…In most of MS patients studied, an elevated antibody titre to C. pneumoniae EB antigens was seen and was present in the CSF of them [74]. Increased antibody titres to C. pneumoniae were seen in about 20% of other neurological disease controls [24,38].…”

Section: Multiple Sclerosismentioning

confidence: 99%

“…RNA of the picornavirus Coxsackie B3 (CVB3) is detected in the heart muscle of 40%-50% of patients with dilated cardiomyopathy (DCM), which is defined by enlargement of cardiac chambers, thinning of ventricular walls, and reduced www.intechopen.com myofibrillar contractility [71]. Several bacterial infections (e.g., with Chlamydia species in particular) are also epidemiologically linked to human heart disease [6,12,24].…”

Section: Heart Diseases Inflammatory Diseasesmentioning

confidence: 99%

“…A tentative relationship between MS and streptococcal infection has been suggested. And finally acute rheumatic fever, which presents several weeks after infection with Streptococcus pyogenes in which, the Molecular resemblance between the bacterial M-protein and human glycoproteins results in a breakdown of self-tolerance in genetically susceptible individuals [24,58].…”

Section: Autoimmune Disorders Induced By Infectionmentioning

confidence: 99%

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Pathogenesis of Chlamydia pneumonia Persistent Illnesses in Autoimmune Diseases

Honarmand¹

2012

Chlamydia

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Section: Multiple Sclerosismentioning

confidence: 93%

Section: Multiple Sclerosismentioning

confidence: 99%

Section: Heart Diseases Inflammatory Diseasesmentioning

confidence: 99%

Section: Autoimmune Disorders Induced By Infectionmentioning

confidence: 99%

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Pathogenesis of Chlamydia pneumonia Persistent Illnesses in Autoimmune Diseases

Honarmand¹

2012

Chlamydia

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“…. ) infections [12][13][14][15][16]. However, SLE is associated with a wide array of autoAbs including specificities with no discernible connection to pathogens.…”

Section: Introductionmentioning

confidence: 99%

Chronic bacterial infection activates autoreactive B cells and induces isotype switching and autoantigen‐driven mutations

et al. 2015

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The links between infections and the development of B-cell-mediated autoimmune diseases are still unclear. In particular, it has been suggested that infection-induced stimulation of innate immune sensors can engage low affinity autoreactive B lymphocytes to mature and produce mutated IgG pathogenic autoantibodies. To test this hypothesis, we established a new knock-in mouse model in which autoreactive B cells could be committed to an affinity maturation process. We show that a chronic bacterial infection allows the activation of such B cells and the production of nonmutated IgM autoantibodies. Moreover, in the constitutive presence of their soluble antigen, some autoreactive clones are able to acquire a germinal center phenotype, to induce Aicda gene expression and to introduce somatic mutations in the IgG heavy chain variable region on amino acids forming direct contacts with the autoantigen. Paradoxically, only lower affinity variants are detected, which strongly suggests that higher affinity autoantibodies secreting B cells are counterselected. For the first time, we demonstrate in vivo that a noncross-reactive infectious agent can activate and induce autoreactive B cells to isotype switching and autoantigen-driven mutations, but on a nonautoimmune background, tolerance mechanisms prevent the formation of consequently dangerous autoimmunity.Keywords: Affinity maturation r Autoreactive B cell r B-cell tolerance r Germinal center r Infection Additional supporting information may be found in the online version of this article at the publisher's web-site 132Sophie Jung et al. Eur. J. Immunol. 2016. 46: 131-146 Introduction B-cell receptors (BCRs) are assembled in developing B-lymphocyte precursors via a stochastic process of joining immunoglobulin (Ig) genes. These random rearrangements inevitably result in the genesis of multiple receptors that recognize self-antigens (Ags) [1]. Despite the fact that known mechanisms of central tolerance take place in the bone marrow, many self-reactive B cells escape toward the periphery [2][3][4][5]. Most of them are the so-called natural autoimmune B cells with a mature naïve phenotype, which produce-in normal individuals-small amounts of polyreactive low affinity IgM autoantibodies (Abs) devoid of somatic mutations. A recent study performed in mice also suggests that quiescent autoreactive B cells persist in the adult repertoire and could serve as a source of pathogenic autoAbs under circumstances that still have to be defined [6]. Both genetic background and environmental factors could influence B-cell maturation in a way that favors the appearance of high affinity IgG switched autoAbs. Among known environmental factors, epidemiological studies have clearly linked infections with the occurrence of autoimmune diseases in humans and in animal models [7]. In some organ-specific autoimmune diseases, this link is attributed to molecular mimicry between pathogens and self-Ags [8][9][10][11]. The role of such mechanism in the breakdown of B-cell tolerance during systemic auto...

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Interactions of antisera to different Chlamydia and Chlamydophila species with the ribosomal protein RPS27a correlate with impaired protein synthesis in a human choroid plexus papilloma cell line

et al. 2017

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Chlamydia trachomatis (CT) and the Chlamydophila species (CS) Chlamydophila pneumoniae (CPn), and Chlamydophila psittaci (CPs) are suggested to induce autoantibodies causative of several human autoimmune disorders like rheumatoid arthritis and systemic lupus erythematosus (SLE). The aim of the present study was therefore to identify cellular protein interaction partners with antisera to CT (α-CT) or CS (α-CS) and to identify functional consequences of such interaction in vitro. As detected with a commercial first trimester human prenatal brain multiprotein array (hEXselect, Engine, Germany), the most frequent interaction partner with both α-CT and α-CS was the ribosomal small subunit protein RPS27a. This could be confirmed by Western blot analysis with a recombinant RPS27a sample. In addition, immunocytochemistry with both antisera in the human choroid plexus papilloma cell line HIBCPP revealed a granular cytoplasmic staining, and Western blot analysis with whole-cell protein samples of HIBCPP cells revealed both antisera to label protein bands of different molecular weights and intensity. By 2D Western blot analysis and mass spectrometry, one of the protein spots interacting with α-CT could be identified as the RPS27a. Finally, two different methods for the detection of protein synthesis activity, the SUnSET technique and an HPG fluorescence assay revealed both antisera to cause reduced translational activity in HIBCPP cells. Together with previous findings of RPS27a as an autoimmune target in a mouse model of systemic lupus erythematosus (SLE), these results suggest that infections with CT and/or CS could induce SLE-associated immune modifications. However, direct evidence for a pathogenic role of these interactions for SLE demands further investigations.

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Acute Chlamydia pneumoniae infection in the pathogenesis of autoimmune diseases

Cited by 25 publications

References 19 publications

Pathogenesis of Chlamydia pneumonia Persistent Illnesses in Autoimmune Diseases

Pathogenesis of Chlamydia pneumonia Persistent Illnesses in Autoimmune Diseases

Chronic bacterial infection activates autoreactive B cells and induces isotype switching and autoantigen‐driven mutations

Interactions of antisera to different Chlamydia and Chlamydophila species with the ribosomal protein RPS27a correlate with impaired protein synthesis in a human choroid plexus papilloma cell line

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