Acute Chlamydia trachomatis respiratory infection in Infants

Mishra, Kamal Narain; Bhardwaj, Pankaj; Mishra, Anuradha; Kaushik, Anil

doi:10.4103/0974-777x.83525

Cited by 12 publications

(15 citation statements)

References 15 publications

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“…A prevalência de infecção respiratória por C. trachomatis de 9,9% encontrada neste estudo está de acordo com dados publicados na literatura que relatam taxas que variam de 7 a cerca de 30% nos primeiros 6 meses de vida [7][8][9][10][11][12][13][14][15][16]20 . Os resultados do presente estudo chamam atenção especial ao fato da infecção por C. trachomatis ter sido encontrada apenas em lactentes com menos de 5 meses de idade, principalmente nos menores de 2 meses, um grupo que representou 75% dos casos.…”

Section: Discussionunclassified

“…Esse evento já foi previamente descrito. Os autores sugerem que a transmissão da infecção possa ocorrer após ruptura da bolsa amniótica ou intra-útero e não exclusivamente através do canal de parto 16,28,29 .…”

Section: Discussionunclassified

“…No entanto, a sensibilidade desses testes com amostras nasofaríngeas varia de 33 a 90% 21 . Neste estudo, a detecção direta de C. trachomatis IgM foi utilizada para o diagnóstico -a sensibilidade para esse teste sendo estimada de 75 a 89% 15,16 e a especificidade em 88% 16 .…”

Section: Achados Radiológicosunclassified

“…No entanto, ela é causa importante de conjuntivite de inclusão e infecções respiratórias em recém-nascidos 6 , assim como de infecção do trato respiratório inferior (ITRI) nos primeiros 6 meses de vida [7][8][9][10][11][12][13][14][15][16] . Cerca de 10 a 20% das crianças de mães infectadas desenvolvem pneumonia [6][7][8][9][10][11][12][13][14][15][16][17] , com repercussões médicas e sociais consideráveis que poderiam ser evitadas com um bom acompanhamento pré-natal.…”

Section: Introductionunclassified

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Chlamydia trachomatis: a major agent of respiratory infections in infants from low-income families

Souza

Girão²,

Simões³

et al. 2012

J Pediatr (Rio J)

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Objectives: To determine the prevalence of lower respiratory tract infection (LRTI) due to Chlamydia trachomatis in newborn infants and to describe the clinical, laboratory, and radiological characteristics of the disease. Methods:A cross-sectional study carried out over a 12-month period. All infants up to 6 months of age admitted consecutively at the Centro Pediátrico Professor Hosannah de Oliveira of the Universidade Federal da Bahia in Salvador, Brazil, and diagnosed with LRTI according to clinical and/or radiological criteria were included in the study. C. trachomatis infection was diagnosed by the enzyme-linked immunosorbent assay (ELISA) for the detection of IgM-class antibodies. The prevalence of LRTI by C. trachomatis was determined and the prevalence ratios for the infection and clinical or laboratory variables were calculated. Results:One hundred and fifty-one infants were submitted to serology for C. trachomatis and 15 (9.9%) tested positive. Chlamydial infection was found only in infants under 5 months of age, mainly in those aged under 2 months. Three of the infants with C. trachomatis infection were born by cesarean section. Conjunctivitis and eosinophilia had occurred in 33.3% of the cases. Chest X rays were abnormal in 92.0% of cases. There was an association between C. trachomatis infection and the duration of hospitalization exceeding 15 days (p = 0.0398) and oxygen therapy (p = 0.0484). Conclusions:There was a high prevalence of C. trachomatis respiratory infection in the population studied. The infection was associated with a more severe form of the disease, emphasizing the importance of testing pregnant women for this infection to avoid infection in the newborn infant. ResumoObjetivos: Determinar a prevalência de infecção do trato respiratório inferior (ITRI) por Chlamydia trachomatis em lactentes internados e descrever as características clínicas, laboratoriais e radiológicas da doença. Métodos:Este foi um estudo do tipo corte transversal, realizado durante um período de 12 meses. Foram incluídos todos os lactentes de até 6 meses internados consecutivamente no Centro Pediátrico Professor Hosannah de Oliveira da Universidade Federal da Bahia, em Salvador, BA, com diagnóstico clínico ou clínico-radiológico de ITRI. O diagnós-tico de infecção por C. trachomatis foi realizado através da pesquisa de anticorpos da classe IgM, utilizando-se o ensaio imunoenzimático (ELISA). A prevalência de ITRI por C. trachomatis foi determinada, e foram calculadas as razões de prevalência para essa infecção e variáveis clínicas e laboratoriais. Resultados:Cento e cinquenta e um lactentes realizaram sorologia para C. trachomatis, das quais 15 (9,9%) foram positivas. A infecção por C. trachomatis ocorreu unicamente entre os menores de 5 meses, principalmente naqueles menores de 2 meses. Três crianças com infecção por C. trachomatis nasceram de parto cesáreo. Conjuntivite e eosinofilia ocorreram em 33,3% dos casos. As radiografias de tórax se mostraram alteradas em 92% dos casos. Demonstrou-se associação ...

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Section: Discussionunclassified

Section: Achados Radiológicosunclassified

Section: Introductionunclassified

See 2 more Smart Citations

Chlamydia trachomatis: a major agent of respiratory infections in infants from low-income families

Souza

Girão²,

Simões³

et al. 2012

J Pediatr (Rio J)

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“…Tveganje za vertikalni prenos klamidijske okužbe na otroka je 60-70 % pri vaginalnem porodu in 8 % pri carskem rezu. 3,4 Pljučnica se razvije pri 10-20 % novorojenčkov, ki se rodijo materam s klamidijsko okužbo, medtem ko se vnetje oče-sne veznice pojavi pri 35-50 %. 2,5 Okužba dihal z bakterijo C. trachomatis je bila dokazana pri 10 od 148 (7 %) dojenčkov, mlajših od 6 mesecev, ki so bili sprejeti v bolnišnico zaradi težav z dihanjem.…”

Section: Uvodunclassified

Pljučnica pri dojenčku, povzročena z bakterijo Chlamydiae trachomatis

et al. 2016

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Chlamydia trachomatis is the most common bacterial pathogen causing sexually transmitted infections. As prenatal screening for C. trachomatis and treatment of pregnant women is not practice in Slovenia, perinatal transmission of C. trachomatis may therefore occur. We present a case of infant chlamydial pneumonia to illustrate that a high index of suspicion is necessary to make the diagnosis in an afebrile infant with cough and “bronchiolitis”. Unnecessary investigations can be avoided and treatment can be promptly instituted if a diagnosis is made on time.

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Influence of different delivery modes on the clinical characteristics of Chlamydia trachomatis pneumonia

et al. 2018

Eur J Pediatr

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Infants delivered by cesarean comprise approximately one-fifth of those affected. The Chlamydia trachomatis titers and peripheral blood leukocyte counts of the vaginal delivery group were higher than those of the cesarean delivery group. Age of onset, liver enzymes, pulmonary inflammation, and pneumonia absorption were not different between groups. What is Known: • Chlamydia trachomatis is an important pathogen that causes lower respiratory tract infections in infants. • C. trachomatis is primarily transmitted to infants through the infected mother, resulting in Chlamydia trachomatis pneumonia subsequently. What is New: • Vaginal delivery and cesarean delivery can result in Chlamydia trachomatis pneumonia transmission; however, cesarean delivery accounts for ~ 20% of cases. • C. trachomatis volume in the respiratory tract and the number of peripheral blood leukocytes in infants delivered vaginally were higher than those in infants delivered by cesarean.

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Acute Chlamydia trachomatis respiratory infection in Infants

Cited by 12 publications

References 15 publications

Chlamydia trachomatis: a major agent of respiratory infections in infants from low-income families

Chlamydia trachomatis: a major agent of respiratory infections in infants from low-income families

Pljučnica pri dojenčku, povzročena z bakterijo Chlamydiae trachomatis

Influence of different delivery modes on the clinical characteristics of Chlamydia trachomatis pneumonia

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