Acute Coinfection with Hepatitis B and Hepatitis C Viruses

Yan, Brian; Lee, Samuel S.

doi:10.1155/2005/514813

Cited by 9 publications

(4 citation statements)

References 5 publications

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“…HCV superinfection is more frequent, while HBV superinfection is rare [ 7 - 8 ]. In addition, acute HBV/HCV coinfection is more prevalent in PWID [ 9 ]. Most HBV/HCV-coinfected patients have HCV RNA levels similar to those in patients with HCV mono-infection, but relatively lower levels of serum HBV DNA compared to patients with chronic HBV mono-infection [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B and C coinfection in a real-life setting: viral interactions and treatment issues

Papadopoulos¹,

Papavdi

Pavlidou³

et al. 2018

aog

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Background:Only limited data concerning hepatitis B (HBV) and C viruses (HCV) coinfection are available. Direct-acting antivirals (DAAs) may be more effective for HCV clearance than interferon (IFN)-based regimens with a risk of HBV reactivation.Methods:We retrospectively enrolled 40 HBV/HCV-coinfected patients to evaluate their clinical profile and treatment outcomes.Results:Chronic dual infection was present in 25/40 (62.5%) patients, acute HCV superinfection in 5/40 (12.5%) patients and acute HBV superinfection in 10/40 (25%). Twenty-five patients (62.5%) were treated: 16/25 (64%) with IFN, 4/25 (16%) with nucleot(s)ide analogs (NUCs) and 5/25 (20%) with DAAs. Of the 16 patients treated with IFN-based therapy, 6 (37.5%) achieved both sustained virological response (SVR) and HBsAg clearance. Of the 4 patients treated with NUCs, one (25%) achieved both SVR and HBsAg clearance. All five patients treated with DAAs (100%) achieved SVR, while one case of HBV reactivation was recorded. Fifteen of the 40 patients (37.5%) did not receive any treatment. Eight of them (53.5%) presented with acute HBV superinfection: spontaneous HCV clearance was recorded in 5/8 (62.5%), while HBsAg clearance occurred in 6/8 (75%). Three of them (20%) presented with acute HCV superinfection; spontaneous HCV clearance was recorded in one of the three (33.5%). The other four patients (26.5%) presented with dual HBV/HCV infection.Conclusions:A significant proportion of patients presented with active HBV replication. Treatment with DAAs seems to be efficacious for HCV eradication. However, clinicians should be aware of HBV reactivation. HBV superinfection may lead to both HBsAg and HCV clearance.

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Section: Introductionmentioning

confidence: 99%

Hepatitis B and C coinfection in a real-life setting: viral interactions and treatment issues

Papadopoulos¹,

Papavdi

Pavlidou³

et al. 2018

aog

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“…According to an Italian investigation that showed active HBV-HCV indicators in 30 patients with HCV infection, the chronicity rates were equivalent to individuals with a single infection with either of the viruses. Biphasic alanine aminotransferase elevation was also observed in the case of HBV-HCV coinfection ( Yan and Lee, 2005 ). Several reports have documented that de novo HCV superinfection in the setting of chronic HBV infection can result in HBeAg seroconversion and clearance of HBsAg.…”

Section: Diagnosis Of Coinfectionmentioning

confidence: 99%

Insights Into the Coinfections of Human Immunodeficiency Virus-Hepatitis B Virus, Human Immunodeficiency Virus-Hepatitis C Virus, and Hepatitis B Virus-Hepatitis C Virus: Prevalence, Risk Factors, Pathogenesis, Diagnosis, and Treatment

et al. 2022

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Human immunodeficiency virus, hepatitis B virus, and hepatitis C virus are three blood-borne viruses that can cause major global health issues by increasing severe morbidity. There is a high risk of coinfection with these viruses in individuals because of their same transmission routes through blood using shared needles, syringes, other injection equipment, sexual transmission, or even vertical transmission. Coinfection can cause various liver-related illnesses, non-hepatic organ dysfunction, followed by death compared to any of these single infections. The treatment of coinfected patients is complicated due to the side effects of antiviral medication, resulting in drug resistance, hepatotoxicity, and a lack of required responses. On the other hand, coinfected individuals must be treated with multiple drugs simultaneously, such as for HIV either along with HBV or HCV and HBV and HCV. Therefore, diagnosing, treating, and controlling dual infections with HIV, HBV, or HCV is complicated and needs further investigation. This review focuses on the current prevalence, risk factors, and pathogenesis of dual infections with HIV, HBV, and HCV. We also briefly overviewed the diagnosis and treatment of coinfections of these three blood-borne viruses.

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“…While the long-term outcome of co-infection or superinfection with different hepatotropic viruses responsible for chronic liver disease like HBV, HDV and HCV is expected to be poor [3,[7][8][9]12], the short-term evolution of these infrequent conditions is still largely unknown, especially when these infection are diagnosed in their acute phase [5,13], like in our patient. Chen et al reported HCV chronicization among subjects diagnosed with a concomitant HBV-HCV co-infection [13], while Yan and Lee described the first case of spontaneous clearance of both HBV and HCV after an acute co-infection [14]. On the other hand, an already advanced HCV hepatitis had its virus cleared without a specific therapy also during HIV infection [15].…”

Section: Discussionmentioning

confidence: 99%

Fulminant hepatitis by concurrent acute HBV-HCV infection successfully treated with antivirals while seeking for an orthotopic liver transplantation

Mastroianni

Greco²,

Mauro³

et al. 2022

Medical Journal of Viral Hepatitis

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Acute Coinfection with Hepatitis B and Hepatitis C Viruses

Cited by 9 publications

References 5 publications

Hepatitis B and C coinfection in a real-life setting: viral interactions and treatment issues

Hepatitis B and C coinfection in a real-life setting: viral interactions and treatment issues

Insights Into the Coinfections of Human Immunodeficiency Virus-Hepatitis B Virus, Human Immunodeficiency Virus-Hepatitis C Virus, and Hepatitis B Virus-Hepatitis C Virus: Prevalence, Risk Factors, Pathogenesis, Diagnosis, and Treatment

Fulminant hepatitis by concurrent acute HBV-HCV infection successfully treated with antivirals while seeking for an orthotopic liver transplantation

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