Acute Colitis Associated with Etodolac

Abstract

We describe two patients in whom acute colitis developed during etodolac treatment. Symptoms resolved when etodolac was stopped. In one, symptoms of colitis recurred with reexposure to the drug. The clinical and pathologic findings were consistent with de novo colitis from etodolac.

Management of refractory inflammatory bowel disease

“…Because many nonsteroidal anti-inflammatory drugs are available over-the-counter, physicians tend to underestimate the use of these medications. Nonsteroidal anti-inflammatory drugs are a well-described cause of acute colitis, even in patients without IBD [77,78]. Nonsteroidal anti-inflammatory drugs have been associated with flares of both UC and CD in several case series and case-control studies [79][80][81][82][83][84].…”