Background: In children, Staphylococcus aureus infects growing, long bones causing osteomyelitis. While the symptoms are recognizable, its occurrence in children is quite rare. Purpose: To highlight a novel case of pediatric osteomyelitis with delirium. Presentation: A 10-year old male presented to the emergency room with a fever and limited range of motion, swelling, and pain in the right clavicular region. His condition declined over two days, developing tachycardia and delirium. Laboratory and imaging studies revealed an abscess in the chest wall as well as severe myositis and cellulitis. The patient was treated with surgical drainage and IV antibiotics, leading to resolution of the patient’s condition. Conclusion: This case report will help physicians in the pediatric or emergency department settings consider, identify, and accurately assess patients for osteomyelitis in developing treatment plans to resolve their patients’ conditions.