Acute corneal hydrops during pregnancy with spontaneous resolution after corneal cross-linking for keratoconus: a case report

Stock, Ricardo Alexandre; Thumé, Thaís; Bonamigo, Elcio Luiz

doi:10.1186/s13256-017-1201-y

Cited by 18 publications

(19 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Certain eye diseases have been associated with pregnancy, such as corneal ectatic diseases and glaucoma. 1–3 Fluctuations of sex hormones during pregnancy may influence the intraocular pressure (IOP), central corneal thickness (CCT), and corneal biomechanical properties of pregnant women. 4–7 Increase in CCT and decrease trend in IOP are known to occur along the pregnancy period, especially in the second and third trimesters when compared to the non-pregnant and the post-partum period.…”

Section: Introductionmentioning

confidence: 99%

Changes in corneal biomechanics during pregnancy in Chinese healthy female

Yang

et al. 2020

European Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose: To evaluate the changes of corneal biomechanics and the intraocular pressure during pregnancy in a Chinese healthy female population. Methods: A total of 222 unrelated Chinese females were recruited: 52 non-pregnant, 15 pregnant in the first trimester, 68 pregnant in the second trimester, and 87 pregnant in the third trimester. The intraocular pressure and corneal biomechanical parameters, including corneal-compensated intraocular pressure, Goldmann-correlated intraocular pressure, corneal hysteresis, and corneal resistance factor, were measured by an Ocular Response Analyzer G3. Central corneal thickness was measured by Lenstar (LS900). Results: Corneal hysteresis and corneal resistance factor were significantly higher in pregnant women at the second and third trimesters. Corneal-compensated intraocular pressure was lower in women at the third trimester of pregnancy ( p = 0.023), but the difference became insignificant after adjustment for corneal hysteresis. Central corneal thickness was marginally higher in pregnant women than non-pregnant women ( p = 0.032). There was a negative correlation between corneal-compensated intraocular pressure and corneal hysteresis ( r = −0.337, p < 0.001) and a positive correlation between central corneal thickness and corneal hysteresis ( r = 0.711, p < 0.0001). After adjustment for corneal-compensated intraocular pressure, corneal hysteresis remained significantly higher in the second and third trimesters of pregnant women than non-pregnant women ( p = 0.031, p = 0.005). Conclusion: This study revealed a significant increase in corneal hysteresis and corneal resistance factor in the second and third trimesters. The increase of corneal hysteresis was independent of corneal-compensated intraocular pressure, indicating pregnant females have unique characteristics in corneal-compensated intraocular pressure and corneal biomechanical properties that may be related to glaucoma and corneal ectatic diseases in pregnancy.

show abstract

Section: Introductionmentioning

confidence: 99%

Changes in corneal biomechanics during pregnancy in Chinese healthy female

Yang

et al. 2020

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Methods like pneumatic descemetopexy have been shown to fasten the speed of recovery 7–9. Two case reports where acute CH developed in a post-CXL cornea showed a complete resolution time of 7–8 days 2 10. The same was 21 days in the above described clinical case.…”

Section: Discussionmentioning

confidence: 69%

Rapid spontaneous resolution of corneal hydrops in post-CXL keratitis

et al. 2021

View full text Add to dashboard Cite

An 11-year-old boy presented with right eye post-Corneal Collagen Cross-Linking (CXL) keratitis, which was complicated by acute corneal hydrops (CH). Keratitis was managed by topical antibiotics, and CH was managed conservatively. Cornea was monitored with serial anterior segment optical coherence tomography (ASOCT) scans. Spontaneous resolution of CH usually takes 8–12 weeks, but in this case it completely resolved in 3 weeks. Rapid resolution of CH after post-CXL keratitis could be attributed to a thinner cornea, increased interlamellar cohesive strength between collagen fibrils of corneal stroma coupled with normal functioning endothelial pump.

show abstract

“…Stock and al. (6) reported a case of a 26-year-old woman who developed acute hydrops 7 months after uneventful standard CXL in one eye during the fifth month of pregnancy. Hydrops resolved, and the authors postulated that CXL led to the greater resistance of aqueous passage through the cornea, which accelerated the healing process.…”

Section: Discussionmentioning

confidence: 99%

“…The introduction of cross-linking (CXL) has changed the course of KC progression with a high rate of success in halting the disease (3) . Yet, three reports (4)(5)(6) revealed that KC can progress to corneal hydrops months to years after CXL. To our knowledge, this is the first described case of acute hydrops followed by corneal perforation five years after CXL.…”

Section: Introductionmentioning

confidence: 99%

Acute hydrops followed by corneal perforation five years after corneal cross-linking for keratoconus

Jovanović¹,

Nikolić²,

Seiler³

et al. 2023

ABO

View full text Add to dashboard Cite

We report a case of acute corneal hydrops followed by corneal perforation five years after corneal cross-linking for keratoconus. A healthy 24-year-old female patient underwent Dresden protocol cross-linking in her left eye due to advanced keratoconus. After five years of a stable cornea, she returned with epiphora, blurred vision, and a soft left eye. Acute hydrops and corneal perforation were diagnosed. There was no history of pregnancy, atopy, eye rubbing, trauma, or contact lens use. Local antibiotic and eye patching were applied. Three months after the resolution of the acute episode, she retained useful visual acuity with no need for further surgery. Although cross-linking efficiently halts keratoconus, progression can occur, leading to corneal hydrops and perforation, even in the absence of any risk factors.

show abstract

Acute corneal hydrops during pregnancy with spontaneous resolution after corneal cross-linking for keratoconus: a case report

Cited by 18 publications

References 10 publications

Changes in corneal biomechanics during pregnancy in Chinese healthy female

Changes in corneal biomechanics during pregnancy in Chinese healthy female

Rapid spontaneous resolution of corneal hydrops in post-CXL keratitis

Acute hydrops followed by corneal perforation five years after corneal cross-linking for keratoconus

Contact Info

Product

Resources

About