Acute Cytomegalovirus Infection Superimposed on Corticosteroid-Naieve Ulcerative Colitis

Abstract

Most cases of cytomegalovirus (CMV)

Cytomegalovirus Infection in Patients with Active Inflammatory Bowel Disease

“…Although our study had a limited number of patients with CD, a higher incidence of CMV in UC compared to CD is consistent with prior reports [8,22]. We found the prevalence of CMV infection in patients with active UC to be lower than previously reported in patients with acute severe colitis (21-38%) [20][21][22][23][24] and steroid-refractory colitis (32-36%) [17,23,25]. This finding may be due to the inclusion of patients with mild to moderate disease activity in our study, unlike previous studies that selected patients with more severe disease.…”

“…Initial studies reported CMV inclusion bodies in colectomy specimens with fulminant or steroid-refractory UC [8,15,16]. In addition, treatment with steroids [17], cyclosporine [18], anti-TNF agents [19], and leukapharesis [20] has been associated with an increased risk of CMV infection. However, other studies have challenged the pathogenicity of CMV in active IBD by demonstrating a lack of correlation of CMV and clinical severity of IBD [21].…”

Toxic Megacolon Associated with Cytomegalovirus Infection in a Patient with Steroid-naïve Ulcerative Colitis

“…Therefore, the diagnosis of concurrent CMV disease in UC patients requires a high degree of certainty. CMV infection can occur regardless of the degree of colonic involvement in UC, i.e., whether the entire colon is involved or only the left side (6,(10)(11)(12)(13)(14)(15). The gold standard for confirming CMV disease of the colon includes endoscopic biopsies taken from the mucosa and ulcer bed.…”

A retrospective study on clinician's practice on testing and treating for cytomegalovirus infection in patients with acute ulcerative colitis in a tertiary care center in India

“…[14][15][16][17][18][19][20][21] In our study CMV was detected in 5 patients who had used only 5-ASA and no immunosuppressant in the past for disease control.…”