Acute dapsone poisoning with methemoglobinemia: a case report

Hamzaoui, Hamza El; Chajai, Idriss; Ouazzani, Mohamed Chahidi El; Benhalima, Abdelkader; Arfaoui, Manal; Alilou, M.

doi:10.11604/pamj.2022.43.20.34069

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…Methylene blue acts as an electron donor by NADPH-methemoglobin and reduces methemoglobinemia. Ascorbic acid and charcoal are other alternatives to methylene blue [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

A Chest Pain Conundrum: Dapsone-Induced Methemoglobinemia in a Heart Transplant Patient

Akopyan,

Golubykh,

Freitas

et al. 2023

Cureus

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We present the case of a 39-year-old male with a past medical history of orthotopic heart transplantation who presented with chest pain and dyspnea on exertion. He was diagnosed with dapsone-induced methemoglobinemia toward the end of his hospital course, and his condition clinically improved with the discontinuation of the offending agent. This case highlights the importance of medication review and history-taking. Clinicians should be mindful of dapsone-induced methemoglobinemia, especially when encountering patients with dyspnea and a history of dapsone intake.

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“…Methylene blue acts as an electron donor by NADPH-methemoglobin and reduces methemoglobinemia. Ascorbic acid and charcoal are other alternatives to methylene blue [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

A Chest Pain Conundrum: Dapsone-Induced Methemoglobinemia in a Heart Transplant Patient

Akopyan,

Golubykh,

Freitas

et al. 2023

Cureus

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“…An alternative treatment is ascorbic acid, which can be utilized when MB is unavailable or contraindicated. There have been a few cases in the current literature detailing the use of ascorbic acid in cases of methemoglobinemia; these are listed in Table 1 [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Up to 10 g can be administered in a single dose or in divided doses.…”

Section: Discussionmentioning

confidence: 99%

Phenazopyridine-Induced Methemoglobinemia in a Jehovah’s Witness Treated with High-Dose Ascorbic Acid Due to Methylene Blue Contradictions: A Case Report and Review of the Literature

et al. 2023

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Methemoglobinemia is an acute medical emergency that requires prompt correction. Physicians should have a high degree of suspicion of methemoglobinemia in cases that present with hypoxemia that does not resolve with supplemental oxygenation, and they should confirm this suspicion with a positive methemoglobin concentration on arterial blood gas. There are multiple medications that can induce methemoglobinemia, such as local anesthetics, antimalarials, and dapsone. Phenazopyridine is an azo dye used over-the-counter as a urinary analgesic for women with urinary tract infections, and it has also been implicated in causing methemoglobinemia. The preferred treatment of methemoglobinemia is methylene blue, but its use is contraindicated for patients with glucose-6-phosphatase deficiency or those who take serotonergic drugs. Alternative treatments include high-dose ascorbic acid, exchange transfusion therapy, and hyperbaric oxygenation. The authors report a case of a 39-year-old female who took phenazopyridine for 2 weeks to treat dysuria from a urinary tract infection and subsequently developed methemoglobinemia. The patient had contraindications for the use of methylene blue and was therefore treated with high-dose ascorbic acid. The authors hope that this interesting case promotes further research into the utilization of high-dose ascorbic acid for managing methemoglobinemia in patients who are unable to receive methylene blue.

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“…This study [19] reports a case of acute Dapsone poisoning with methemoglobinemia treated solely with ascorbic acid and activated charcoal. This study highlights the possible efficacy of ascorbic acid and activated charcoal in treating methemoglobinemia due to Dapsone poisoning.…”

Section: Acute Dapsone Poisoning With Methemoglobinemia: a Case Reportmentioning

confidence: 99%

State of the Art on Suicide Studies in Morocco: Trends, Risk Factors and Implications for Prevention

El Ouardi,

Hassouny El Hassan,

El Feniche

et al. 2024

TOPHJ

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Suicide remains a pressing public health concern in Morocco, yet the research landscape surrounding this issue is relatively sparse. To address this gap, we conducted a comprehensive review of 96 articles about suicide in Morocco, sourced from the Scopus database. Focusing on the period from 2014 to 2023, 68 articles were selected for detailed analysis, revealing critical insights into the multifaceted nature of suicidal behavior in the country. Through a thematic categorization of the literature, encompassing domains such as Suicidal Behavior and Mental Health, Epidemiology and Risk Factors, Psychological Disorders, Suicide Prevention, Medical Emergencies, and Methodology and Technology, our review synthesized vital findings and trends in Moroccan suicide research. Notably, the analysis illuminated concerning patterns of suicidal behavior and identified significant risk factors, including mental health disorders, psychosocial stressors, and socio-economic challenges. In light of these findings, urgent attention is warranted to develop and implement targeted prevention strategies tailored to the unique needs of the Moroccan population to mitigate the impact of suicide on individuals, families, and communities alike.

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Acute dapsone poisoning with methemoglobinemia: a case report

Cited by 4 publications

References 4 publications

A Chest Pain Conundrum: Dapsone-Induced Methemoglobinemia in a Heart Transplant Patient

A Chest Pain Conundrum: Dapsone-Induced Methemoglobinemia in a Heart Transplant Patient

Phenazopyridine-Induced Methemoglobinemia in a Jehovah’s Witness Treated with High-Dose Ascorbic Acid Due to Methylene Blue Contradictions: A Case Report and Review of the Literature

State of the Art on Suicide Studies in Morocco: Trends, Risk Factors and Implications for Prevention

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