Acute Delirium Associated With Levofloxacin

Kogan, Yana; Elias, Nizar; Paz, Alona; Odeh, Majed

doi:10.14740/jocmr3538w

Cited by 8 publications

(2 citation statements)

References 20 publications

(22 reference statements)

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“…Elderly critically ill patients are at high risk for delirium, which has an average frequency of 60% and increases length of stay and mortality (60). Drug-induced delirium is well-described with sedatives, anticholinergics and narcotics but can also occur, albeit less frequently, with various antibiotics including cephalosporins, macrolides, and rarely with quinolones (61, 62). The effect of antibiotics on central nervous system functions should be meticulously evaluated in a critically ill patient with altered mental status (63).…”

Section: Management Of Infected Critically-ill Elderly Patientmentioning

confidence: 99%

Infections in the Elderly Critically-Ill Patients

et al. 2019

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Infections are leading causes of morbidity and mortality in the advanced aged. Various factors including immunosenescens, comorbid chronic diseases, and alterations in normal physiological organ functions may modify the frequency and severity of infections in elderly patients. Normal body reactions to ensuing infection, such as increased body temperature, may be blunted in those patients causing difficulties in differential diagnosis between infection and other diseases. In severe infections the respiratory and urinary tracts are the most frequently involved systems which may be accompanied by severe sepsis. Bacteremia and sepsis are also associated with indwelling vascular catheters in the elderly who are admitted to the intensive care unit (ICU). Older patients are more vulnerable to the Clostridioides difficile infection, as well. Although the general management of infections in severely ill elderly patients is not different than in younger patients, meticulous care in fluid management and careful individualized optimization in antibiotic therapy, along with the other principals of antimicrobial stewardship are warranted in order to prevent increased mortality caused by infection. Organized team management when treating critically ill elderly patients in the ICU is essential and will reduce the morbidity and mortality due to infection in such patients.

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Section: Management Of Infected Critically-ill Elderly Patientmentioning

confidence: 99%

Infections in the Elderly Critically-Ill Patients

et al. 2019

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“…There was abrupt onset of mania-like symptoms following treatment with levofloxacin that resolved rapidly after treatment with risperidone and lorazepam in our case, suggestive of possible diagnosis of levofloxacin-induced mania. Neuropsychiatric reactions have been reported with levofloxacin, most commonly delirium [10][11][12][13][14][15][16][17][18] and occasionally acute psychosis. [19][20][21] We did not find any report of mania associated with levofloxacin in PubMed using "levofloxacin" and "mania" as search terms.…”

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confidence: 99%