Acute disseminated encephalomyelitis after Japanese B encephalitis vaccination

Randomized, Double‐Blind, Placebo‐Controlled Phase 3 Trial of the Safety and Tolerability of IC51, an Inactivated Japanese Encephalitis Vaccine

“…Cases of neurological events, such as encephalitis, encephalopathy, seizures, and peripheral neuropathy [20 -22], have been reported after vaccination with JE-VAX. Although these neurological events occurred very rarely (1 in 2.3 million vaccinees) [26], they were of particular concern to physicians. In a study conducted by the Centers for Disease Control and Prevention, hives and facial swelling were reported in 0.2% and 0.1% of JE-VAX vaccinees, respectively [9].…”

North American Encephalitic Arboviruses

“…The mechanism by which arboviruses kill infected neurons is incompletely understood, although several flaviviruses including WNV and Japanese encephalitis virus can induce apoptosis in infected neurons [22]. Arboviruses do not generally infect oligodendrocytes, so acute demyelination is not a typical feature of arbovirus encephalitis, although rare cases of post-infectious acute disseminated encephalomyelitis have been reported after dengue and St. Louis encephalitis and following immunization with the vaccine strain of Japanese B encephalitis virus [23,24]. …”

Adult post‐infectious thalamic encephalitis: acute onset and benign course

“…, 1989), but rarely in inflammatory conditions (Masson and Colombani, 2002). Cases of inflammatory bilateral and symmetric thalamic lesions have been reported repeatedly in the neuropaediatric literature (Ohtaki et al. , 1992; Cusmai et al.…”