Acute disseminated encephalomyelitis after live rubella vaccination

Tsuru, Tomohiko; Mizuguchi, Masashi; Ohkubo, Yasuyuki; Itonaga, Nobuyoshi; Momoi, Mariko Y.

doi:10.1016/s0387-7604(00)00102-9

Cited by 29 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the spinal MR findings of ADEM are nonspecific, high-intensity lesions distributed asymmetrically in the white matter of the cord, extending over several segments (from Th-7 to Th-11 in our patient) on T2-weighted images are consistent with the spinal form of ADEM. [6][7][8] Although gadolinium enhancement is not consistent in ADEM, it can be identified in the acute stages and can be suppressed by corticosteroid therapy, 9 as observed in our patient.…”

Section: Discussionmentioning

confidence: 41%

Acute disseminated encephalomyelitis following dengue fever

Yamamoto

Takasaki

Yamada

et al. 2002

Journal of Infection and Chemotherapy

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 41%

Acute disseminated encephalomyelitis following dengue fever

Yamamoto

Takasaki

Yamada

et al. 2002

Journal of Infection and Chemotherapy

View full text Add to dashboard Cite

“…12,17 We have argued that RRVD is caused by immunopathologic inflammatory responses directed at virus persisting in synovial macrophages. 1,18 -20 A number of virusmediated immune pathologies are currently treated with steroids; these include croup in children, 21 virus-induced asthma flares, 22 Bell palsy, 23 viral encephalitis, 24 and hepatitis C virus arthritis. 25 Although RRVD can be severe and debilitating at onset, the disease progressively resolves within 3 to 6 months, there is no discernible articular damage, and there is no evidence of RRVD leading to autoimmune arthritis.…”

Section: Discussionmentioning

confidence: 99%

Corticosteroid Therapy in an Alphaviral Arthritis

Mylonas¹,

Harley²,

Purdie³

et al. 2004

JCR: Journal of Clinical Rheumatology

View full text Add to dashboard Cite

show abstract

“…1 ADEM has also been described after immunizations. 5,6 Despite reports of the possible association between infection and ADEM, there is no clear understanding of the relationship between the infectious agent and the onset of demyelination. There is experimental evidence in mice for a relationship between coronavirus and CNS demyelination.…”

mentioning

confidence: 99%

Detection of Coronavirus in the Central Nervous System of a Child With Acute Disseminated Encephalomyelitis

Yeh¹,

Collins²,

Cohen³

et al. 2004

Pediatrics

269

View full text Add to dashboard Cite

ABSTRACT. We present a case in which human coronavirus was detected in the cerebrospinal fluid of a child presumed to have acute disseminated encephalomyelitis. In murine models, coronavirus has been found to cause a chronic demyelinating condition that resembles multiple sclerosis. Additionally, there is in vitro evidence of human coronavirus's ability to infect neural cells. This case report provides additional support for the hypothesis that coronavirus may be an important etiologic factor in the pathogenesis of demyelinating disease in humans. Pediatrics 2004;113:e73-e76. URL: http://www.pediatrics. org/cgi/content/full/113/1/e73; coronavirus, HCoV, acute disseminated encephalomyelitis, ADEM, postinfectious encephalitis, demyelination, child.ABBREVIATIONS. ADEM, acute disseminated encephalomyelitis; CNS, central nervous system; MRI, magnetic resonance imaging; CSF, cerebrospinal fluid; PCR, polymerase chain reaction; IgG, immunoglobulin G; RT, reverse transcription; HCoV, human coronavirus; MS, multiple sclerosis.A cute disseminated encephalomyelitis (ADEM) is a monophasic, demyelinating disease of the central nervous system (CNS) that primarily affects children and young adults. It is characterized by high-signal-intensity lesions in the white matter of the brain and spinal cord on T2-weighted magnetic resonance imaging (MRI). These lesions may be independent of the clinical findings. Children may present with diffuse encephalopathy, seizures, optic neuritis, hemiparesis, and/or symptoms suggestive of spinal cord transection.The epidemiology of the condition is unknown. A review of cases presenting to a children's hospital suggested a prevalence of ϳ4.5 cases per 10 000 pediatric hospital admissions, exclusive of newborns. 1 The etiology of the illness is cryptogenic, although the disorder is generally thought to be due to a paraor postinfectious process. Certainly, many case reports in the literature suggest an infectious process before the onset of CNS symptoms, and some have identified specific infectious agents in cases of ADEM. [2][3][4] However, in most cases, a specific etiologic infectious agent is not identified. For example, in a recent retrospective review of cases of ADEM, clinicians were able to identify an infectious agent in only 1 of 18 cases. 1 ADEM has also been described after immunizations. 5,6 Despite reports of the possible association between infection and ADEM, there is no clear understanding of the relationship between the infectious agent and the onset of demyelination. There is experimental evidence in mice for a relationship between coronavirus and CNS demyelination. [7][8][9] Little is known, however, about this virus's relationship to demyelinating disease in humans. Indeed, there have been no case reports of this virus in relation to ADEM. We report a case of demyelinating disease in a child in which cerebrospinal fluid (CSF) and nasopharyngeal specimens were positive for human coronavirus (HCoV) by polymerase chain reaction (PCR) and in whom a fourfold rise in antibody titer ...

show abstract

Acute disseminated encephalomyelitis after live rubella vaccination

Cited by 29 publications

References 8 publications

Acute disseminated encephalomyelitis following dengue fever

Acute disseminated encephalomyelitis following dengue fever

Corticosteroid Therapy in an Alphaviral Arthritis

Detection of Coronavirus in the Central Nervous System of a Child With Acute Disseminated Encephalomyelitis

Contact Info

Product

Resources

About