Acute Disseminated Encephalomyelitis Associated With Acute Rheumatic Fever

Saygı, Semra; Olgaç, Asburçe; Üçkardeş, Yasemin; Alehan, Füsun; Varan, Birgül

doi:10.1016/j.pediatrneurol.2010.10.018

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Other pathogens anecdotally involved in ADEM have been Toxoplasma gondii [3], Plasmodium falciparum [28], Cryptococcus neoformans [29], Haemophilus influenzae type b [30], Leptospira sp. [31], Streptococcus pyogenes [32], Borrelia burgdorferi [33], atypical bacteria (i.e., Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila) [13], Rickettsia sp. [13], and Campylobacter jejuni [13].…”

Section: A Complex Bind Of Infection-triggered Autoimmune Phenomena Amentioning

confidence: 99%

A spectrum of inflammation and demyelination in acute disseminated encephalomyelitis (ADEM) of children

Esposito

Pietro

Madini

et al. 2015

Autoimmunity Reviews

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Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system that involves multifocal areas of the white matter, rarely the gray matter and spinal cord, mainly affecting children and mostly occurring 1-2weeks after infections or more rarely after vaccinations. Though a specific etiologic agent is not constantly identified, to evaluate carefully patient's clinical history and obtain adequate samples for the search of a potential ADEM causal agent is crucial. In the case of a prompt diagnosis and adequate treatment, most children with ADEM have a favorable outcome with full recovery, but in the case of diagnostic delays or inappropriate treatment some patients might display neurological sequelae and persistent deficits or even show an evolution to multiple sclerosis. The suspicion of ADEM rises on a clinical basis and derives from systemic and neurologic signs combined with magnetic resonance imaging of the central nervous system. Other advanced imaging techniques may help an appropriate differential diagnosis and definition of exact disease extension. Although there is no standardized protocol or management for ADEM, corticosteroids, intravenous immunoglobulin, and plasmapheresis have been successfully used. There is no marker that permits to identify the subset of children with worse prognosis and future studies should try to detect any biological clue for prevision of neurologic damage as well as should optimize treatment strategies using an approach based on the effective risk of negative evolution.

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Section: A Complex Bind Of Infection-triggered Autoimmune Phenomena Amentioning

confidence: 99%

A spectrum of inflammation and demyelination in acute disseminated encephalomyelitis (ADEM) of children

Esposito

Pietro

Madini

et al. 2015

Autoimmunity Reviews

View full text Add to dashboard Cite

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“…Akut dissemine ensefalomiyelit de (ADEM) grup A beta hemolitik streptokokkal enfeksiyonların ardından nadir de olsa görülebilmektedir. Ülkemizden Saygı ve arkadaşlarının (18) (8,16,20,21). Pozitron emisyon tomografisi hastalığın aktif fazındaki kaudat nukleus ve putamendeki metabolik değişiklikleri gösterir, bununla birlikte bulgular düzeldiğinde normale dönmektedir (22).…”

Section: Introductionunclassified

Sydenham’s Chorea: A Case Report and Review of the Literature

Karadağ‐Öncel¹,

Özsürekçi²,

Konuşkan³

et al. 2012

J Pediatr Inf

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Sydenham's chorea is a disorder of the central nervous system characterized by sudden, involuntary, arrhythmic, choreic, and purposeless movements. It is a nonsuppurative sequel of group A streptococcal tonsillopharyngitis, which is known to be a common cause of chorea. According to the 1992 modified Jones criteria, acute rheumatic fever is a major criterion and is sufficient evidence on which to base a diagnosis. Despite the decreased incidence of Sydenham's chorea, isolated cases and also sometimes epidemics may be seen. We discuss the case report with the literature and describe the history, clinical features, and management of a 11-year-old female child with Sydenham's chorea who presented to our pediatric infectious disease department. Our aim is to make an accurate diagnosis and provide appropriate treatment as soon as possible to prevent acute rheumatic fever and to emphasize the nonsuppurative complications.

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