Acute disseminated encephalomyelitis in conjunction with inflammatory bowel disease

Aziz, Majid; Stivaros, Stavros; Fagbemi, Andrew; Vassallo, Grace

doi:10.1016/j.ejpn.2012.06.007

Cited by 6 publications

(6 citation statements)

References 9 publications

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“…Acute disseminated encephalomyelitis, however, has been reported in pediatric patients with IBD. 19 In summary, this is the first report of a child with IBD who developed a fulminant and fatal CNS process immediately following the very first dose of infliximab. Although lack of an autopsy prevents us from providing a definitive etiology for his injuries, neuroimaging is most consistent with a multifocal ischemic and hemorrhagic process.…”

Section: Discussionmentioning

confidence: 95%

Fatal Central Nervous System Disease Following First Infliximab Infusion in a Child With Inflammatory Bowel Disease

Bäumer

Ouahed

Verhave

et al. 2016

Pediatric Neurology

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Section: Discussionmentioning

confidence: 95%

Fatal Central Nervous System Disease Following First Infliximab Infusion in a Child With Inflammatory Bowel Disease

Bäumer

Ouahed

Verhave

et al. 2016

Pediatric Neurology

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“…Demyelination has also been reported in 11 patients with IBD (4 with CD and 7 with UC) treated with medications other than anti-TNF-a (steroids, 5-acetylsalicylic acids, immunosuppressants) [17,47,[53][54][55]. Mean age of these patients was 38 years (range, 0-70), with an equal sex distribution.…”

Section: Methodsmentioning

confidence: 90%

Inflammatory bowel disease and demyelination: more than just a coincidence?

Katsanos

Κατσάνος

2014

Expert Review of Clinical Immunology

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Infliximab and other anti-TNF-α agents have been implicated for drug-induced demyelination in patients with inflammatory bowel diseases (IBDs). We evaluated existing data from MEDLINE and EMBASE and conducted a narrative review to investigate further the aforementioned association. Our literature search highlighted 34 case reports, 3 case-control studies, 1 prospective and 7 retrospective cohort studies published in English. Available data suggest that IBD patients can manifest demyelinating events in both central and peripheral nervous system, however, they are still insufficient to conclude whether anti-TNF-α therapies are an independent risk factor for demyelination. Prospective cohort studies with internal control groups are needed to estimate the true incidence of demyelinating disorders in patients with IBD and to elucidate if anti-TNF-α therapy increases further the risk of demyelination.

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“…Neurological complications of idiopathic chronic inflammatory bowel disease (IBD), with an estimated prevalence between 47 and 50% depending on the series, normally appear after the diagnosis of IBD, coinciding or worsening with the exacerbation of IBD [1][2][3]. This neurological involvement is often related either to a dysimmune mechanism or to a prothrombotic state [4,5].…”

Section: Discussionmentioning

confidence: 99%

“…This neurological involvement is often related either to a dysimmune mechanism or to a prothrombotic state [4,5]. However, multiple sclerosis (MS) and optic neuritis remain the most common inflammatory demyelinating diseases of the central nervous system (CNS) associated with IBD [1,6,7].…”

Section: Discussionmentioning

confidence: 99%

“…This is explained by the disruption of T cell function, as well as that of antigenpresenting cells, which is common between the two diseases [1,2,8,9]. Therefore, cellular immune suppressive therapies are effective in treating both diseases [10,11].…”

Section: Sagittal Brain Mri Flair Sequence Showing Multiple Signal Intensities Involving the Corpus Callosum And Inferior Cerebellar Pedumentioning

confidence: 99%

See 1 more Smart Citation

Chronic Inflammatory Bowel Disease and Demyelination of the Central Nervous System: A Report on Two Cases

Oumerzouk¹,

Klevor²,

Chraa³

et al. 2022

RNA Viruses Infection

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The objective of this article is to investigate the link between chronic inflammatory bowel disease (IBD) and central nervous system (CNS) demyelination. CNS demyelinating disorders in IBD are rare complications and are due to a dysimmune mechanism. We report the clinical cases of two patients followed for IBD. The first patient had Crohn’s disease for 12 years and developed acute disseminated encephalomyelitis (ADEM) 1 month after the first course of the anti-tumor necrosis factor alpha (anti-TNF-alpha), infliximab. The second patient, treated for ulcerative colitis with salazopyrin, developed multiple sclerosis (MS) 5 months after the start of her disease. MS and optic neuritis remain the inflammatory demyelinating diseases of the CNS most frequently associated with IBD. The activation of T lymphocytes during IBD plays an essential role in the pathogenesis of MS and ADEM in a genetically predisposed population. It is currently recommended that patients with IBD be evaluated clinically and by MRI for subclinical demyelinating lesions in order to guide therapeutic management.

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Acute disseminated encephalomyelitis in conjunction with inflammatory bowel disease

Cited by 6 publications

References 9 publications

Fatal Central Nervous System Disease Following First Infliximab Infusion in a Child With Inflammatory Bowel Disease

Fatal Central Nervous System Disease Following First Infliximab Infusion in a Child With Inflammatory Bowel Disease

Inflammatory bowel disease and demyelination: more than just a coincidence?

Chronic Inflammatory Bowel Disease and Demyelination of the Central Nervous System: A Report on Two Cases

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