Acute Dystonic Reaction Caused by Gabapentin

Rohman, Lebur; Hebron, Andrew

doi:10.1016/j.jemermed.2013.08.024

Cited by 11 publications

(8 citation statements)

References 7 publications

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“…Potential explanations for this trend are tolerance and addiction, as described in two clinical case discussions from France and the United States, respectively . Interestingly, according to American and European case reports, those who used gabapentin but did not have a prescription for it often took doses that fell within clinical guidelines, regardless of motivations behind use, although the doses were not spread out over the course of a day and it was unclear how often an individual dosed per day .…”

Section: Resultsmentioning

confidence: 69%

“…More than half of the case report papers ( n = 14) arose from patients presenting to a hospital or general clinic with overdose or withdrawal‐like symptoms ; two came from substance abuse clinics , three from psychiatric facilities , two from the penal system , one from postmortem toxicology findings and one from poison center reports .…”

Section: Resultsmentioning

confidence: 92%

“…A variety of motivations behind gabapentin misuse were identified, many that related to substance abuse behaviors in general, which included: recreational use , control of mood and/or anxiety , potentiating the effects of drug abuse treatment and intentional self‐harm . Case reports substantiated those intentions , and also identified the following: pain , reduced cravings for/managed withdrawal from other drugs , substituted for other drugs and addiction to gabapentin .…”

Section: Resultsmentioning

confidence: 99%

“…Despite initial views that gabapentin had no abuse potential , there have been numerous published case reports of gabapentin abuse by substance abusers in the community and penal system . The purpose of this review is to describe the international scope of gabapentin abuse (i.e.…”

Section: Introductionmentioning

confidence: 99%

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Gabapentin misuse, abuse and diversion: a systematic review

2016

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Background and Aims Since its market release, gabapentin has been presumed to have no abuse potential and subsequently has been prescribed widely off-label, despite increasing reports of gabapentin misuse. This review estimates and describes the prevalence and effects of, motivations behind, and risk factors for gabapentin misuse, abuse, and diversion. Methods Databases were searched for peer-reviewed articles demonstrating gabapentin misuse, characterized by taking a larger dosage than prescribed or taking gabapentin without a prescription, and diversion. All types of studies were considered; grey literature was excluded. Thirty-three articles met inclusion criteria, consisting of 23 case studies and 11 epidemiological reports. Published reports came from the USA, the UK, Germany, Finland, India, South Africa, and France, and two analyzed websites not specific to a particular country. Results Prevalence of gabapentin misuse in the general population was reported to be 1%, 40–65% among individuals with prescriptions, and between 15–22% within populations of people who abuse opioids. An array of subjective experiences reminiscent of opioids, benzodiazepines, and psychedelics were reported over a range of doses, including those within clinical recommendations. Gabapentin was primarily misused for recreational purposes, self-medication, or intentional self-harm and was misused alone or in combination with other substances, especially opioids, benzodiazepines, and/or alcohol. Individuals with histories of drug abuse were most often involved in its misuse. Conclusions Epidemiological and case report evidence suggests that the antiepileptic and analgesic medication gabapentin is being misused internationally at a rate of about 1%, with substance abuse populations at special risk for misuse/abuse.

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Section: Resultsmentioning

confidence: 69%

Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gabapentin misuse, abuse and diversion: a systematic review

2016

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“…A central dopamine transmission deficit is believed to result with overactive striatal acetylcholine release. Anti-cholinergic medications may reverse this over active release [ 4 ]. However, clinical suspicion and early diagnosis is essential to prevent fatal outcomes.…”

Section: Discussionmentioning

confidence: 99%

Acute nontraumatic torticollis in a patient with right lower quadrant pain: case report

Yaylak¹,

Zeren²,

Bayhan³

et al. 2015

Pan Afr Med J

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Right lower quadrant pain is one of the most common symptoms of the emergency patients. For accurate diagnosis and treatment; the patients must be questioned and examined very well. Also accompanying conditions due to right lower quadrant pain may be noticed. In this case presentation, we discussed a patient who was presented with right lower quadrant pain and cervical dystonia. By limiting the usage of metoclopramide the patient was followed seamlessly. In this case presentation we want to accentuate that a patient who with abdominal pain may be presented with rare symptoms such of dystonia. In such conditions a detailed anamnesis and physical examination are the first steps of the evaluation to prevent potential hazardous outcomes. In particular, a surgeon must be always carefully while taking history and examining the patient.

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Delirium in Organ Transplant Recipients

Maldonado

2022

Transplant Psychiatry

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Acute Dystonic Reaction Caused by Gabapentin

Cited by 11 publications

References 7 publications

Gabapentin misuse, abuse and diversion: a systematic review

Gabapentin misuse, abuse and diversion: a systematic review

Acute nontraumatic torticollis in a patient with right lower quadrant pain: case report

Delirium in Organ Transplant Recipients

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