Acute Effect of Antipyretic Analgesics, Alone or in Combination With Alcohol, on Human Psychomotor Skills Related to Driving

Linnoila, Markku; Seppαlä, Timo; Mattila, Mauri J.

doi:10.1111/j.1365-2125.1974.tb01697.x

Cited by 33 publications

(12 citation statements)

References 9 publications

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“…TA is tolerated quite well by the stomach (26), which may explain the lack of gastric side-effects in our study. In man, PG inhibitors inhibit vasodilatation in the chlorpropamide-alcohol test (8) and reduce or enhance the depressant effects of ethanol on psychomotor skills (27). The prolongation of bleeding time caused by ethanol is potentiated by aspirin (28).…”

Section: Discussionmentioning

confidence: 99%

Hangover Headache and Prostaglandins: Prophylactic Treatment with Tolfenamic Acid

Kaivola¹,

Parantainen²,

Österman³

et al. 1983

Cephalalgia

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Tolfenamic acid (TA), a potent inhibitor of prostaglandin (PG) biosynthesis and action, was tested prophylactically against hangover symptoms in 30 healthy volunteers in a double-blind cross-over study. One capsule of TA (200 mg) or placebo was taken before starting to drink alcohol and another before going to bed. The hangover symptoms were evaluated in the morning. TA was found significantly better than placebo in the subjective evaluation of drug efficacy (p less than 0.001) and in reducing the reported hangover symptoms in general (p less than 0.01). In the TA group, significantly lower symptom scores were obtained for headache (p less than 0.01), and for nausea, vomiting, irritation, tremor, thirst and dryness of mouth (all p less than 0.05). In a separate study with eight participants, plasma levels of PGs were followed during ingestion of alcohol with or without TA. The plasma concentrations of PGE2 and TXB2 (a metabolite of thromboxane A2) were lower in the TA group during alcohol ingestion, while PGF2 alpha and 6-keto-PGF1 alpha (a metabolite of prostacyclin) were unaffected. TXB2 correlated with blood alcohol levels in a U-shaped manner.

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Section: Discussionmentioning

confidence: 99%

Hangover Headache and Prostaglandins: Prophylactic Treatment with Tolfenamic Acid

Kaivola¹,

Parantainen²,

Österman³

et al. 1983

Cephalalgia

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“…Linnoila et al . found that a single dose of 50 mg indomethacin slightly impaired performance in driving‐related attention and coordination tests such as a choice reaction time test, two‐coordination test and a divided attention test. On the other hand, Bruce‐Jones et al .…”

Section: Discussionmentioning

confidence: 98%

“…To the best of our knowledge, the present study is the first to assess the effect of indomethacin on complex attention demanding tasks relevant to falls. Previous research mainly focused on psychomotor functioning . Linnoila et al .…”

Section: Discussionmentioning

confidence: 99%

CNS effects of indomethacin: should patients be cautioned about decreased mental alertness and motor coordination?

Hegeman

Bemt

Weerdesteyn

et al. 2013

Brit J Clinical Pharma

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AIMSIn many European countries as well as in the USA, the leaflet, or even the packaging of indomethacin, contains a specific warning to refrain from activities requiring mental alertness and motor coordination, such as driving a car. In this placebo-controlled randomized study with a crossover design we attempted to find evidence for that warning. METHODSIndomethacin 75 mg slow release or a visually identical placebo with similar flavour was taken orally twice daily for 2.5 days. It was suggested that indomethacin affects the motor coordination required to avoid obstacles successfully during walking and that this effect will be even stronger when simultaneously performing a cognitive task that puts mental alertness to the test. Nineteen healthy middle-aged individuals (60 Ϯ 4.7 years, eight female) performed an obstacle avoidance task on a treadmill), combined with a cognitive secondary task. Biceps femoris (BF) muscle response times, obstacle avoidance failure rates and composite scores ((100 ¥ accuracy)/verbal response time) were used to evaluate the data. RESULTSNo differences between indomethacin and placebo were found on the outcome measures regarding motor coordination, avoidance failure rates (P = 0.81) and BF response times (P = 0.47), nor on the performance on the secondary cognitive task (P = 0.12). CONCLUSIONSEven though surrogate methods were used, the current study provides evidence to suggest that there might be no need to caution patients who experience CNS side effects after indomethacin use to avoid activities requiring quick and adequate reactions, such as walking under challenging circumstances and maybe also driving a car.

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“…cyclosporin) [175] or even causing adverse reactions e.g. orthostatic hypotension (with felodipine) [176], increased incidence of hepatitis (with isoniazid) [177] or hepatotoxicity (with methotrexate) [178], bleeding (with aspirin) [179], and impaired motor coordination (with phenothiazines and phenylbutazone) [180].…”

Section: Interactions With Alcoholmentioning

confidence: 99%

Drug Metabolism

2005

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Acute Effect of Antipyretic Analgesics, Alone or in Combination With Alcohol, on Human Psychomotor Skills Related to Driving

Cited by 33 publications

References 9 publications

Hangover Headache and Prostaglandins: Prophylactic Treatment with Tolfenamic Acid

Hangover Headache and Prostaglandins: Prophylactic Treatment with Tolfenamic Acid

CNS effects of indomethacin: should patients be cautioned about decreased mental alertness and motor coordination?

Drug Metabolism

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