2019
DOI: 10.1097/iae.0000000000002058
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Acute Effect of Caffeine on Macular Microcirculation in Healthy Subjects

Abstract: We found a significant decrease in macular flow area (superficial, deep, and choriocapillaris) and vessel density after caffeine intake. Our findings are consistent with previous studies using other techniques. We believe that the results of this preliminary study will be useful in future studies about this topic.

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Cited by 28 publications
(23 citation statements)
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“…The dark chocolate in our study contained 108.5 mg of caffeine, as we used the same product utilized by Grassi et al [37], who performed high-performance liquid chromatography to analyze chocolate. The amount of caffeine in the dark chocolate bars in our study was about half the dose that Karti et al [40] used in their study; therefore, it is possible that the vasodilating effect of flavonoids in chocolate might have been limited by the vasoconstrictor effect of caffeine. It is also important to underline that Karti et al [40] used a 6mm × 6mm macular angiogram of the choriocapillaris layer for analysis, which we did not use due to the poor and un-reliable quality of scans.…”
Section: Discussionmentioning
confidence: 70%
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“…The dark chocolate in our study contained 108.5 mg of caffeine, as we used the same product utilized by Grassi et al [37], who performed high-performance liquid chromatography to analyze chocolate. The amount of caffeine in the dark chocolate bars in our study was about half the dose that Karti et al [40] used in their study; therefore, it is possible that the vasodilating effect of flavonoids in chocolate might have been limited by the vasoconstrictor effect of caffeine. It is also important to underline that Karti et al [40] used a 6mm × 6mm macular angiogram of the choriocapillaris layer for analysis, which we did not use due to the poor and un-reliable quality of scans.…”
Section: Discussionmentioning
confidence: 70%
“…The amount of caffeine in the dark chocolate bars in our study was about half the dose that Karti et al [40] used in their study; therefore, it is possible that the vasodilating effect of flavonoids in chocolate might have been limited by the vasoconstrictor effect of caffeine. It is also important to underline that Karti et al [40] used a 6mm × 6mm macular angiogram of the choriocapillaris layer for analysis, which we did not use due to the poor and un-reliable quality of scans. Furthermore, Karti et al [40] used a choroidal slab with boundaries 31 to 59 µm below the retinal pigmented epithelium, whereas we used a newer OCT-A software version (2017.1.0.151), which yields a slab at −9 µm to 31 µm offset from Bruch's membrane, making results difficult to compare.…”
Section: Discussionmentioning
confidence: 70%
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