Acute effect of oxygen therapy on exercise tolerance and dyspnea perception in ILD patients

Ora, Josuel; Coppola, Angelo; Perduno, Andrea; G, Manzetti; Puxeddu, Ermanno; Rogliani, Paola

doi:10.4081/monaldi.2021.1925

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…Perhaps the 6MWD was slightly overestimated in the patients with ILD, as all patients conducted the test with oxygen supplementation. Others have reported a consistent acute improvement of the 6MWD on oxygen supplementation in patients with ILD [ 35 , 36 ]. This could explain why for a given 6MWD, the PA intensity in daily life was lower.…”

Section: Discussionmentioning

confidence: 74%

Physical activity pattern of patients with interstitial lung disease compared to patients with COPD: A propensity-matched study

et al. 2022

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Introduction Physical activity (PA) is reduced in patients with interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD). Evidence about the PA pattern of patients with ILD is scarce. If PA of patients with ILD would be comparable to COPD, it is tempting to speculate that existing interventions focusing on enhancing PA could be as effective in ILD as already shown in COPD. Therefore, we aimed to compare PA and the correlates with PA in matched patients with ILD, COPD, and healthy subjects. Materials and methods Patients with ILD (n = 45), COPD (n = 45) and healthy subjects (n = 30) were propensity matched. PA level, pattern, and PA correlations with lung function and physical performance (6-minute walking distance and quadriceps force) were compared between groups. Results Daily number of steps was similar in both patient groups (mean±SE: 5631±459 for ILD, 5544±547 for COPD, p = 0.900), but significantly lower compared to healthy subjects (10031±536, p<0.001 for both). Mean intensity of PA tended to be lower in the ILD group (mean±SE metabolic equivalents of task per day: 1.41±0.04) compared to COPD (1.52±0.05, p = 0.074) and healthy individuals (1.67±0.04, p<0.001). The pattern of PA over one day was found to be similar between the three groups. Lastly, the correlation between PA and 6-minute walking distance was significantly weaker in patients with ILD compared to patients with COPD (respectively r = 0.348 and r = 0.739; p<0.05 for both). Conclusions For a given functional reserve, patients with ILD perform an equal amount of steps but perform PA at lower intensity compared to patients with COPD. Both groups are less active compared to healthy control subjects. Functional exercise capacity was shown to be only moderately related to PA. This can potentially influence the effectiveness of PA interventions that can be expected.

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Section: Discussionmentioning

confidence: 74%

Physical activity pattern of patients with interstitial lung disease compared to patients with COPD: A propensity-matched study

et al. 2022

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“…The study by Ora et al, which evaluated ILD patients during the 6MWT on ambient air and during oxygen administration (mean flow 6 ± 3 L/min to maintain SpO2 nadir ≥88%), showed that if administered at the right flow, oxygen therapy in ILD patients significantly improved physical performance (in terms of distance RA: 242 ± 143 m vs. Ox: 345 ± 106 mp < 0.01) and overall dyspnoea. It also improved anxiety at rest and after exercise [16].…”

Section: Quality Of Life and Psychological Implicationsmentioning

confidence: 80%

“…In 76 subjects, they showed a statistically significant improvement in quality of life, UCSDSOBQ scores, global assessments of change in breathlessness, walking ability and activity and in the chest symptom subdomains of K-BILD scores, but not in the psychological symptom domain of K-BILD. This was the first study to focus on the daily life of patients [16,17].…”

Section: Quality Of Life and Psychological Implicationsmentioning

confidence: 99%

Oxygen Therapy during Exercise in Patients with Interstitial Lung Diseases

et al. 2022

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Introduction: ILDs are a varied group of diffuse parenchymal lung diseases associated with high morbidity and mortality. Current treatments can only slow their progression but not cure the disease. Other treatments such as oxygen therapy can also be used as support. We know very little about the effects of oxygen therapy on patients with ILDs. The aim of this study was to collect data from the literature in order to determine whether oxygen therapy can actually decrease the mortality rate or whether it is only suitable for supportive therapy for patients with ILDs. Methods: We reviewed the literature since 2010 on oxygen therapy during exercise in patients with ILDs. Studies that used cardio-pulmonary tests were excluded. We only reviewed those that used the 6 min walking test (6MWT) or the free walking test. We located 11 relevant articles. Results: All the articles except a Japanese study showed an augmentation in oxyhaemoglobin saturation during exercise when oxygen was supplied. A 2018 study called AmbOx provided important data on the effects of oxygen therapy during daily activities, showing significant improvements in quality of life. Conclusions: This review showed that the literature on the benefits of oxygen therapy in patients with ILDs does not provide sufficient evidence to draft specific guidelines. It was not possible to conclude whether oxygen therapy has an effect on mortality or can only play a supportive role.

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Systemic complications of rheumatoid arthritis: Focus on pathogenesis and treatment

Luo

et al. 2022

Front. Immunol.

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As a systemic autoimmune disease, rheumatoid arthritis (RA) usually causes damage not only to joints, but also to other tissues and organs including the heart, kidneys, lungs, digestive system, eyes, skin, and nervous system. Excessive complications are closely related to the prognosis of RA patients and even lead to increased mortality. This article summarizes the serious complications of RA, focusing on its incidence, pathogenesis, clinical features, and treatment methods, aiming to provide a reference for clinicians to better manage the complications of RA.

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Acute effect of oxygen therapy on exercise tolerance and dyspnea perception in ILD patients

Cited by 3 publications

References 28 publications

Physical activity pattern of patients with interstitial lung disease compared to patients with COPD: A propensity-matched study

Physical activity pattern of patients with interstitial lung disease compared to patients with COPD: A propensity-matched study

Oxygen Therapy during Exercise in Patients with Interstitial Lung Diseases

Systemic complications of rheumatoid arthritis: Focus on pathogenesis and treatment

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