Acute effect of renal sympathetic denervation on blood pressure in refractory hypertensive patients with chronic kidney disease

Improvement of the renal function after renal sympathetic denervation in refractory hypertensive patients with chronic kidney disease: Possible predictors

“…Recently, Ott et al reported an observational pilot study in patients with CKD stages 3 and 4 which indicates that treatment of hypertension with renal sympathetic denervation (RSD) decreases BP and slows or even halts the decline of renal function [2], in agreement with our previous results that showed BP control and an increase in estimated glomerular filtration rate (eGFR), especially in the mild stages of CKD [3][4][5], after RSD. Subjects that were considered responders to RSD regarding renal function presented changes in eGFR with order of magnitude higher than 6.2% [4].…”

“…All patients in this study provided written informed consent and were selected according to previously published protocol [5]. The Committee of Ethics in Research of the Medical School of Universidade Federal Fluminense approved the study.…”

Safety and feasibility of transcatheter renal sympathetic denervation using different types of catheter and various radiofrequency settings

“…Some groups used conventional RF-ablation catheters for RSD with varied results, however showing safety with particular protocols [18], [22], [23], [24]. This experimental study showed safety with either conventional RF-catheters or the Symplicity® catheter, in a stepwise testing approach of the different catheters and RF-settings.…”

Renal Denervation in CKD Hypertensive Patients: Would it be Possible to Prevent the Development of Risk Factors Responsible for Sudden Cardiac Death in this Population?

“…18 The Committee of Ethics in Research of the Medical School of Universidade Federal Fluminense approved the study and written informed consent was obtained from every patient. In the period from June 2011 to December 2012, these patients underwent renal sympathetic denervation (RSD).…”

“…Bruising or aneurismal formation was not seen at the puncture site. According to the protocol, 18 in the follow-up period, Doppler ultrasound of the renal arteries was performed one and 6 months after the procedure in all patients and did not show any complication or change in blood flow. Left ventricular mass (LVM) assessed by echocardiography at baseline and 6 months post procedure was calculated from LV linear dimensions using the equation of Devereux.…”