Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) and R(-) MDMA on actigraphy-based daytime activity and sleep parameters in rhesus monkeys.

Berro, Laís F.; Shields, Hannah; Odabas-Geldiay, Melis; Rothbaum, Barbara O.; Andersen, Mônica Levy; Howell, Leonard L.

doi:10.1037/pha0000196

Cited by 3 publications

(1 citation statement)

References 70 publications

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“…• Sessions are usually started in the morning. MDMA's stimulant effect may prevent sleep if the session is started later [16].…”

Section: Mental Preparationmentioning

confidence: 99%

Open MDMA: An Open Source Framework and Practical Guide for the Therapeutic use of MDMA

Groeneveld,

Harper

2024

Preprint

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60% of adults experienced childhood trauma; half develop a mental illness in their life. Symptoms like cognitive distortion, emotional rigidness/insecurity, and impaired compassion increase tribalism, political polarization, and apathy to animal suffering–hobbling our collective capacity to defeat global catastrophic risks. Access to effective care (a crucial support for stopping intergenerational harm) is inadequate for most who need it. MDMA is a promising treatment, but good training is lacking because MDMA is illegal. With legalization immanent, our rigorous and accessible guide to MDMA therapy will: 1) Resource therapeutic MDMA users and clinicians 2) Articulate likely mechanisms of effectiveness, to inform the development of future therapeutic techniquesThis can reduce mental illness by addressing the prevalent, high impact barriers to effective care–increasing collective capacity for collaboration, supporting individuals who end cycles of abuse, and protecting future generations.

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“…• Sessions are usually started in the morning. MDMA's stimulant effect may prevent sleep if the session is started later [16].…”

Section: Mental Preparationmentioning

confidence: 99%

Open MDMA: An Open Source Framework and Practical Guide for the Therapeutic use of MDMA

Groeneveld,

Harper

2024

Preprint

View full text Add to dashboard Cite

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Actigraphic evidence of persistent sleep disruption following repetitive mild traumatic brain injury in a gyrencephalic model

et al. 2023

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We studied the effect of multimodal traumatic brain injuries on daily sleep/activity patterns and related histology. Gyrencephalic ferrets wore actigraphs and received military-relevant brain injuries including shockwaves, strong rotational impact, and variable stress, which were evaluated up to 6 months post injury. Sham and Baseline animals exhibited activity patterns occurring in distinct clusters of high activity, interspersed with periods of low activity. In the Injury and Injury + Stress groups, activity clusters diminished and overall activity patterns became significantly more dispersed at 4 weeks post injury with significant sleep fragmentation. Additionally, the Injury + Stress group exhibited a significant decrease in daytime high activity up to 4 months post injury. At 4 weeks post injury, the reactive astrocyte (GFAP) immunoreactivity was significantly greater in both the injury groups compared to Sham, but did not differ at 6 months post injury. The intensity of immunoreactivity of the astrocytic endfeet that surround blood vessels (visualized with aquaporin 4; AQP4), however, differed significantly from Sham at 4 weeks post injury (in both injured groups) and at 6 months (Injury + Stress only). As the distribution of AQP4 plays a key role in the glymphatic system, we suggest that glymphatic disruption occurs in ferrets after the injuries described here.

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Influence of Pair-housing on Sleep Parameters Evaluated with Actigraphy in Female Rhesus Monkeys

Berro¹,

Pareek²,

Reeves-Darby³

et al. 2022

j am assoc lab anim sci

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Rhesus monkeys are naturally social animals, and behavioral management strategies have focused on promoting pairhousingin laboratory settings as an alternative to individual or group housing. In humans, co-sleeping can have a major impact on bed partners’ sleep, raising the possibility that pair-housing also may influence sleep parameters in monkeys. In the present study, we investigated if pair-housing would impact home-cage partner’s sleep in female rhesus monkeys, and if nighttime separation using socialization panels would alter this pattern. Sleep parameters of 10 experimentally naïve adult female rhesus monkeys (5 pairs) were evaluated for 7 consecutive days using actigraphy monitors attached to primate collars. Paired animals then were separated by socialization panels during the night, and sleep-associated measures were evaluated for 7 consecutive days. The data showed that sleep efficiency was significantly lower when monkeys were pairhoused as compared with when they were separated. On the nights when subjects were pair-housed, a positive correlation was detected for sleep measures (both sleep latency and efficiency) of both members of a pair (R2’s = 0.16–0.5), suggesting that pair-housing influences sleep quality. On nights when subjects were separated, no correlations were observed for sleep measures between members of the pairs (R2’s = 0.004–0.01), suggesting that when separated, the home-cage partner’s sleep no longer influenced the partner’s sleep. Our results indicate that pair-housing has a strong impact on the home-cage partner’s sleep, and that this pattern can be prevented by nighttime separation using socialization panels. Studies evaluating sleep in pair-housed monkeys should consider the effects that the partner’s sleep may have on the subject’s sleep. Sleep is a biologic phenomenon and experimental outcome that affects physical and behavioral health and altered sleep due to pair-housing may affect a range of research outcomes.

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Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) and R(-) MDMA on actigraphy-based daytime activity and sleep parameters in rhesus monkeys.

Cited by 3 publications

References 70 publications

Open MDMA: An Open Source Framework and Practical Guide for the Therapeutic use of MDMA

Open MDMA: An Open Source Framework and Practical Guide for the Therapeutic use of MDMA

Actigraphic evidence of persistent sleep disruption following repetitive mild traumatic brain injury in a gyrencephalic model

Influence of Pair-housing on Sleep Parameters Evaluated with Actigraphy in Female Rhesus Monkeys

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