Acute effects of a high-fat meal with and without red wine on endothelial function in healthy subjects

Djoussé, Luc; Ellison, R. Curtis; McLennan, Christine E.; Cupples, L. Adrienne; Lipinska, Izabella; Tofler, Geoffrey H.; Gokce, Noyan; Vita, Joseph A.

doi:10.1016/s0002-9149(99)00412-9

Cited by 103 publications

(79 citation statements)

References 26 publications

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“…If the corresponding dose of caffeine (60 mg for coffee and 40 mg for tea; Passmore & Eastwood, 1986) had strong vasodilatory effects, up to 3 h after consumption, this might have counteracted the effect of the test fats. However, we found no evidence for an effect of caffeine in the literature Djoussé et al, 1999). Thus, the fact that we did not find an impairment in FMD after a meal rich in either saturated or trans fat cannot be explained by differences in dose or study design.…”

Section: Discussioncontrasting

confidence: 86%

“…Maybe the increase in serum triacylglycerols in our study was too small to counteract such a diurnal variation in FMD; the increase 3.5 h after the meals was moderate, with 0.46 mmol=l after the sat-meal and 0.68 mmol=l after the trans meal. However, many studies that did show an effect on FMD reported similar increases in serum triacylglycerols within the same time frame (Marchesi et al, 2000;Djoussé et al, 1999;Plotnick et al, 1997;Williams et al, 1999).…”

Section: Correlation Between Changes In Serum Triacylglycerols and Flmentioning

confidence: 92%

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Trans monounsaturated fatty acids and saturated fatty acids have similar effects on postprandial flow-mediated vasodilation

et al. 2002

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Objective: Several studies suggest that a fatty meal impairs flow-mediated vasodilation (FMD), a measure of endothelial function. We tested whether the impairment was greater for trans fats than for saturated fats. We did this because we previously showed that replacement of saturated fats by trans fats in a controlled diet decreased FMD after 4 weeks. Design: We fed 21 healthy men two different test meals with 0.9 -1.0 g fat=kg body weight in random order: one rich in saturated fatty acids (Sat), mainly from palm kernel fat, and one rich in trans fatty acids (Trans) from partially hydrogenated soy bean oil. The study was performed in our metabolic ward. We had complete data for both diets of 21 men. Results: FMD increased from a fasting value of 2.3 AE 2.0% of the baseline diameter to 3.0 AE 1.7% after the Sat test meal (95% CI for change 7 0.33, 1.70) and from 2.7 AE 2.3 to 3.1 AE 2.0% after the Trans test meal (95% CI for change 7 0.57, 1.29). The increase after the Sat meal was 0.22 ( 7 1.18 -1.61) FMD% higher than after the Trans meal. Serum triacylglycerols increased by 0.46 AE 0.36 mmol=l after the Sat test meal and by 0.68 AE 0.59 mmol=l after the Trans test meal; a difference of 0.23 (0.07, 0.39) mmol=l. Serum HDL-cholesterol was hardly affected by the test meals. The activity of serum paraoxonase, an esterase bound to HDL, increased slightly after the two test meals but the difference between meals was not significant. Conclusion: FMD was not impaired and not different after test meals with saturated or trans fatty acids. Thus, differences in long-term effects of these fats are not caused by differences in acute effects on the vascular wall.

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Section: Discussioncontrasting

confidence: 86%

Section: Correlation Between Changes In Serum Triacylglycerols and Flmentioning

confidence: 92%

Trans monounsaturated fatty acids and saturated fatty acids have similar effects on postprandial flow-mediated vasodilation

et al. 2002

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“…2,13,14 Furthermore, postprandial hypertriglyceridemia may induce endothelial dysfunction through the direct effects of triglyceride-rich lipoproteins 3,4 and increasing oxidative stress in circulation. 1,15,16 These data indicate that lowering postprandial triglyceride concentration may lead to improvement of endothelial function.…”

Section: Discussionmentioning

confidence: 81%

Xuezhikang, an Extract of Cholestin, Protects Endothelial Function Through Antiinflammatory and Lipid-Lowering Mechanisms in Patients With Coronary Heart Disease

et al. 2004

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Background-Endothelial dysfunction is associated with inflammation and postprandial hypertriglyceridemia. Xuezhikang, an extract of Cholestin, a dietary supplement, has lipid-modulating and antiinflammatory effects. We explored the effects of xuezhikang on endothelial function and high-sensitivity C-reactive protein (hs-CRP) in patients with coronary heart disease (CHD). Methods and Results-We prospectively randomized 50 CHD patients to xuezhikang 1200 mg/d or placebo for 6 weeks.Fasting hs-CRP concentrations, flow-mediated vasodilation (FMD) at 0 and 4 hours, and lipid parameters at 0, 2, 4, and 6 hours were monitored after a high-fat meal (800 calories; 50 g fat) in all patients. All patients underwent a high-fat meal test at the beginning of the study and after 6 weeks of treatment. Postprandial FMD was significantly worse at 4 hours after a high-fat meal (PϽ0.05), and this was associated with the area under the triglyceride curve (TG-AUC) (rϭ0.345, PϽ0.01). After 6 weeks of xuezhikang, fasting hs-CRP levels and TG-AUC (PϽ0.001 for each) decreased. Furthermore, preprandial and postprandial FMD significantly improved (PϽ0.001). There were no significant changes in serum lipids and FMD in the placebo arm. In multivariable regression analysis, changes in TG-AUC and fasting hs-CRP levels were predictive of improvement in preprandial FMD (PϽ0.05). Conclusions-Xuezhikang

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“…Studies have shown that red wine and=or de-alcoholized red wine improve endothelial function, 8,9 while another study did not show an effect with red wine. 16 D espite the signi cance of their results regarding this particular beverage, none of these investigations provided clear evidence of the effect of pure alcohol itself due to their design. Two 8,16 did not test pure alcohol at all.…”

Section: Discussionmentioning

confidence: 94%

Effect of alcohol on endothelial function in healthy subjects

et al. 2003

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Abstract:While studies have shown that red wine improves endothelial function, the effect of pure alcohol, the common denominator of all alcoholic beverages, on endothelial function has not been de ned. The effect of oral intake of alcohol (one ounce -a dose corresponding to two drink equivalents) on ow-mediated dilatation of the brachial artery was studied in 12 healthy subjects using high-resolution ultrasonography according to a randomized, sham procedure-controlled, single-blind protocol. Alcohol produced a signi cant vasodilatation of the brachial artery at resting conditions. Furthermore, it led to a signi cant increase of the brachial artery diameter at reactive hyperemia; however, the percentage ow-mediated dilatation did not change. This study shows, for the rst time, that acute moderate intake of alcohol has a potent dilating effect on large arteries both at resting and at reactive hyperemic conditions, without affecting ow-mediated dilatation as a percentage. This may be useful for explaining the divergent effect of different alcoholic beverages on endothelial function and provides valuable insight into the mechanisms involved in the vascular effects of alcohol.

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Acute effects of a high-fat meal with and without red wine on endothelial function in healthy subjects

Cited by 103 publications

References 26 publications

Trans monounsaturated fatty acids and saturated fatty acids have similar effects on postprandial flow-mediated vasodilation

Trans monounsaturated fatty acids and saturated fatty acids have similar effects on postprandial flow-mediated vasodilation

Xuezhikang, an Extract of Cholestin, Protects Endothelial Function Through Antiinflammatory and Lipid-Lowering Mechanisms in Patients With Coronary Heart Disease

Effect of alcohol on endothelial function in healthy subjects

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