2004
DOI: 10.1016/j.pbb.2004.01.003
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Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening

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Cited by 198 publications
(149 citation statements)
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“…Relatively low doses of ethanol have been shown to induce hyperactivity in larval and adult zebrafish, while higher doses have been shown to reduce activity. 70,71 Thus, ethanol concentration is an important variable in the effect of ethanol on locomotion. mechanism by which ethanol teratogenicity proceeds.…”
Section: Zebrafish Models Of Fasdmentioning
confidence: 99%
“…Relatively low doses of ethanol have been shown to induce hyperactivity in larval and adult zebrafish, while higher doses have been shown to reduce activity. 70,71 Thus, ethanol concentration is an important variable in the effect of ethanol on locomotion. mechanism by which ethanol teratogenicity proceeds.…”
Section: Zebrafish Models Of Fasdmentioning
confidence: 99%
“…These models have several advantages over mammalian models with regard to fertilization, development and transperancy of the egg chorion. The effects of ethanol on zebrafish embryos have been studied by a number of investigators (Bilota et al, 2004;Carvan et al, 2004;Lockwood et al, 2004;Reimers et al, 2004;Arenzana et al, 2006;Li et al, 2007;Tanguay and Reimers, 2008), establishing that the fish can be used as a model organism to study FASD. Compared to zebrafish, medaka are less utilized in studying ethanol-induced toxicity.…”
Section: Introductionmentioning
confidence: 99%
“…Large-scale mutagenic screens in zebrafish and medaka have identified several orthologue genes that are related closely to those involved in human genetic diseases (Naruse et al, 2004). The response of zebrafish embryos to ethanol has been studied by many investigators and zebrafish have been recognized as a useful model for the study of alcohol-induced teratogenic effects (Bilotta et al, 2004;Carvan et al, 2004;Lockwood et al, 2004;Reimers et al, 2004a). In zebrafish, ethanol causes cyclopia, affects visual functions, induces pericardial edema and otolith defects, lowers heart rate, reduces eye diameter, induces axial malformations, delays development, and produces axial blistering (Bilotta et al, 2002(Bilotta et al, , 2004Reimers et al, 2004a).…”
Section: Introductionmentioning
confidence: 99%
“…The effects of ethanol were found to be strain-dependent in zebrafish (Dlugos and Rabin, 2002). Interestingly, ethanol exposure in zebrafish has been shown to modulate aggression and other social behavior (Gerlai, 2003;Lockwood et al, 2004).…”
Section: Introductionmentioning
confidence: 99%