1998
DOI: 10.4141/a97-067
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Acute effects of epidermal growth factor on Na+, K+-ATPase-dependent oxygen consumption and the amount of the enzyme units in enterocytes isolated from the jejunum of chickens

Abstract: -Radford, L. M. 1998. Acute effects of epidermal growth factor on Na + , K + -ATPase-dependent oxygen consumption and the amount of the enzyme units in enterocytes isolated from the jejunum of chickens. Can. J. Anim. Sci. 78: 327-333. Enterocytes from jejunum of male White Leghorn chickens aged 14 d and 20 wk were used to investigate the short-term effect of epidermal growth factor (EGF) on total O 2 uptake (TO 2 ) and Na + , K + -dependent O 2 uptake (OSO 2 ) and intracellular pH (pHi). Total O 2 uptake and O… Show more

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Cited by 6 publications
(2 citation statements)
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“…It has been estimated that 11–18% of the whole energy expenditure in ruminants is used by the gut, and the majority of this energy is spent for Na + K + ATPase activity (6–12%), and protein synthesis (4.0–4.6%). 51 Thus, the absorptive capacity of the small intestine is dependent on the availability of ATP to fuel Na + K + ATPase and to renew epithelial cells. Inefficiencies in mitochondrial function caused by MTX may limit nutrient absorption resulting in weight loss and diarrhea.…”
Section: Discussionmentioning
confidence: 99%
“…It has been estimated that 11–18% of the whole energy expenditure in ruminants is used by the gut, and the majority of this energy is spent for Na + K + ATPase activity (6–12%), and protein synthesis (4.0–4.6%). 51 Thus, the absorptive capacity of the small intestine is dependent on the availability of ATP to fuel Na + K + ATPase and to renew epithelial cells. Inefficiencies in mitochondrial function caused by MTX may limit nutrient absorption resulting in weight loss and diarrhea.…”
Section: Discussionmentioning
confidence: 99%
“…The properties make EGF stably exist in the gastrointestinal system and play a broadly bioactive function on epithelium. In addition to increasing the uptake capability by regulation of Na + chanels and amino acid transporter phosphorylation, this protein seems to promote the mitosis of cells in many species [14] [15][16]. The peculiarity is that EGF interacts with EGFR increase the survival of intestinal epithelium.…”
Section: Introductionmentioning
confidence: 99%