Acute Effects of Estradiol Pretreatment on the Response to &lt;i&gt;d&lt;/i&gt;-Amphetamine in Women

Justice, Angela; Wit, Harriet de

doi:10.1159/000054520

Cited by 91 publications

(59 citation statements)

References 23 publications

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“…Findings in the present study are consistent with clinical studies in which estradiol was administered to follicular phase women before exposure to d-amphetamine (Justice and de Wit, 2000b). Estradiol levels, 10 times the usual follicular phase levels, did not significantly enhance most positive subjective responses to d-amphetamine (Justice and de Wit, 2000b). Women studied at the early follicular phase of the menstrual cycle, when estradiol levels are low, and at the late follicular phase, when estradiol levels are high, also did not respond differently to d-amphetamine (Justice and de Wit, 2000a).…”

Section: Discussionsupporting

confidence: 90%

“…The highest dose of estradiol studied did not alter the cocaine dose-effect curve appreciably from control conditions. Findings in the present study are consistent with clinical studies in which estradiol was administered to follicular phase women before exposure to d-amphetamine (Justice and de Wit, 2000b). Estradiol levels, 10 times the usual follicular phase levels, did not significantly enhance most positive subjective responses to d-amphetamine (Justice and de Wit, 2000b).…”

Section: Discussionsupporting

confidence: 87%

“…Estradiol treatment increased ratings of 'pleasant stimulation' after d-amphetamine in comparison to placebo capsules, but other positive subjective effect ratings (euphoria, 'like drug', and 'feel high') were not significantly increased. Interestingly, estradiol alone increased ratings of 'pleasant stimulation' in women given placebo amphetamine (Justice and de Wit, 2000b).…”

Section: Introductionmentioning

confidence: 96%

“…significantly increased heart rate and positive subjective effects in comparison to placebo, differences in estradiol levels as a function of menstrual cycle phase did not alter the physiologic or subjective effects of d-amphetamine (Justice and de Wit, 2000a). To the best of our knowledge, only one clinical study has examined the effects of estradiol administration on the subjective effects of d-amphetamine in follicular phase women (Justice and de Wit, 2000b). Two groups of women were given d-amphetamine (10 mg, p.o.)…”

Section: Introductionmentioning

confidence: 99%

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Effects of Estradiol on Cocaine Self-Administration and Cocaine Discrimination by Female Rhesus Monkeys

Mello

Negus

Knudson

et al. 2007

Neuropsychopharmacol

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The ovarian steroid hormone, estradiol, enhances the reinforcing and locomotor activating effects of cocaine in rodents under some conditions. The present study evaluated the acute effects of estradiol benzoate (E 2 b) on cocaine self-administration and cocaine discrimination in female rhesus monkeys. Cocaine self-administration (0.10 mg/kg/inj., i.v.) was maintained on a fixed-ratio (FR) 30 schedule of reinforcement, and monkeys had access to cocaine during one 2-h session each day. E 2 b in a cyclodextrin vehicle (0.00001-0.01 mg/kg, i.m.) was administered 30 min before test sessions conducted twice each week. Cocaine doses were administered in an irregular order during each dose-effect curve determination (0.001-0.3 mg/kg/inj.). Blood samples were collected after test sessions to determine 17b-estradiol levels. Banana-flavored food pellets were available on an FR 30 schedule in three 1-h sessions each day. Five monkeys were trained to discriminate cocaine (0.18 mg/kg, i.m.) from saline in a two-key food-reinforced procedure, and the effects of pretreatment with E 2 b in cyclodextrin and in sesame oil were studied. Acute administration of E 2 b did not consistently alter the cocaine self-administration or drug discrimination dose-effect curves in comparison to saline control treatment. Females also did not selfadminister E 2 b (0.00001-0.10 mg/kg, i.v.) above saline levels. Finally, E 2 b (0.0001-0.01 mg/kg, i.m.) did not substitute for cocaine in monkeys trained to discriminate cocaine from saline. Taken together, these data suggest that over the dose range studied, estradiol administration does not consistently alter the abuse-related effects of cocaine in female rhesus monkeys.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Estradiol on Cocaine Self-Administration and Cocaine Discrimination by Female Rhesus Monkeys

Mello

Negus

Knudson

et al. 2007

Neuropsychopharmacol

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“…Justice and de Wit (2000a) found that estradiol given to women during the early follicular phase increases some, but not all, positive subject-rated effects of amphetamine. Others have administered progesterone during the follicular phase, when endogenous levels are negligible, and found that it decreases physiological and positive subject-rated effects of cocaine in women (Evans and Foltin, 2006a;Sofuoglu et al, 2004).…”

Section: Introductionmentioning

confidence: 94%

Effects of menstrual cycle phase on the reinforcing effects of phencyclidine (PCP) in rhesus monkeys

Newman

Thorne

Batulis

et al. 2006

Pharmacology Biochemistry and Behavior

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Substantive evidence indicates that there are sex differences in the reinforcing effects of drugs and gonadal steroid hormones, such as estrogen and progesterone, likely contribute to these differences. Among females, subjective effects of drugs differ as a function of menstrual cycle phase. The purpose of the present study was to compare oral self-administration of phencyclidine (PCP) in female rhesus monkeys (Macaca mulatta) across different phases of the menstrual cycle. Since the 28-day menstrual cycle of nonhuman primates is similar to that of humans, this model could provide important evidence supporting the implication that changes in the levels of gonadal hormones across menstrual phases can alter a drug's reinforcing effects. Oral self-administration of several concentrations of PCP (0.125, 0.25, and 0.5 mg/ml) was examined in three sexually mature female monkeys during 3-h experimental sessions. Menstrual cycle phase was determined by onset of menses, and verified by examining vaginal cytology. Overall, PCP self-administration was greater during the luteal phase, which is normally characterized by high levels of progesterone and moderate levels of estrogen, than the follicular phase, when levels of estrogen are increasing and progesterone levels are low. When examined within each phase, numbers of PCP deliveries were highest during the mid-luteal phase, compared to the early and mid-follicular phases. No differences in selfadministration were observed between early and mid-follicular phases, but a significant difference in PCP deliveries was found between mid-and late luteal phases at the lowest concentration of PCP tested. The results from this study suggest that PCP's reinforcing effects in female monkeys differ as a function of menstrual cycle phase.

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Progesterone effects on subjective and physiological responses to intravenous nicotine in male and female smokers

Sofuoglu

Mitchell

Mooney

2009

Human Psychopharmacology

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Objective Previous studies suggest possible modulatory effects of progesterone on nicotine addiction. The goal of this study was to determine the effects of progesterone, on acute physiological and subjective responses to intravenous (IV) nicotine in overnight abstinent male and female smokers. Methods Twelve smokers, 6 males and 6 females, participated in a double-blind, placebo-controlled, crossover study, which consisted of 2 experimental sessions. Before each session, subjects were treated orally with a single dose of either 200 mg progesterone or placebo. Starting 2 hours following the medication treatment, subjects received an IV saline injection, followed by 0.5 and 1.0 mg/70 kg IV nicotine. Results Progesterone treatment, compared to placebo, enhanced the ratings of “bad effects,” from IV nicotine and attenuated the rating of “drug liking.” Progesterone also enhanced suppression of smoking urges by nicotine as assessed by the Brief Questionnaire on Smoking Urges (BQSU). Conclusions These results suggest that progesterone may alter the subjective effects of nicotine as well as urges to smoke cigarettes. Further studies are warranted to examine the modulation of nicotine’s effects by gonadal hormones.

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Acute Effects of Estradiol Pretreatment on the Response to <i>d</i>-Amphetamine in Women

Cited by 91 publications

References 23 publications

Effects of Estradiol on Cocaine Self-Administration and Cocaine Discrimination by Female Rhesus Monkeys

Effects of Estradiol on Cocaine Self-Administration and Cocaine Discrimination by Female Rhesus Monkeys

Effects of menstrual cycle phase on the reinforcing effects of phencyclidine (PCP) in rhesus monkeys

Progesterone effects on subjective and physiological responses to intravenous nicotine in male and female smokers

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