Acute effects of high- and low-intensity exercise bouts on leukocyte counts

Neves, Pedro Rogério da Silva; Tenório, Thiago; Lins, Tatiana Acioli; Muniz, Maria Tereza Cartaxo; Pithon-Curi, Tânia Cristina; Botero, João Paulo; Prado, Wagner Luiz do

doi:10.1016/j.jesf.2014.11.003

Cited by 74 publications

(60 citation statements)

References 34 publications

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“…For example, Abdossaleh et al [6] reported that high-intensity exercise increased the total leucocyte, lymphocyte, monocyte, and neutrophil counts in college judoists. These findings are further supported by a more recent study in which a greater increase in the leucocyte count after high-intensity exercise in physically healthy and active young males compared to low-intensity exercise and no exercise [7]. McCarthy and Dale [8] also reported that leucocytosis is approximately proportionate to the intensity and duration of the exercise performed.…”

Section: Introductionsupporting

confidence: 66%

Elevation of leukocyte counts is associated with an increase in the intensity and duration of exercise

2018

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Section: Introductionsupporting

confidence: 66%

Elevation of leukocyte counts is associated with an increase in the intensity and duration of exercise

2018

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“…In blood, immediately after exhausting exercise, there is leukocytosis, as reported both in humans (Suchánek et al, 2010) and rodents (Krüger et al, 2008). This increase in blood leukocytes comprises higher counts of monocytes, granulocytes and the main subsets of lymphocytes, i.e., B and T (Th and Tc) cells (Dimitrov et al, 2010;Neves et al, 2015). Lymphocytosis is due to the higher release of catecholamines (Graff et al, 2018).…”

Section: Introductionmentioning

confidence: 91%

Changes in Lymphocyte Composition and Functionality After Intensive Training and Exhausting Exercise in Rats

et al. 2019

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Exhausting exercise can have a deleterious effect on the immune system. Nevertheless, the impact of exercise intensity on lymphocyte composition and functionality remains uncertain. The aim of this study was to establish the influence of intensive training on lymphoid tissues (blood, thymus, and spleen) in Wistar rats. Two intensive training programs were performed: a short program, running twice a day for 2 weeks and ending with a final exhaustion test (S-TE group), and a longer program, including two exhaustion tests plus three runs per week for 5 weeks. After this last training program, samples were obtained 24 h after a regular training session (T group), immediately after an additional exhaustion test (TE group) and 24 h later (TE24 group). The composition of lymphocytes in the blood, thymus, and spleen, the function of spleen cells and serum immunoglobulins were determined. In the blood, only the TE group modified lymphocyte proportions. Mature thymocytes' proportions decreased in tissues obtained just after exhaustion. There was a lower percentage of spleen NK and NKT cells after the longer training program. In these rats, the T group showed a reduced lymphoproliferative activity, but it was enhanced immediately after the final exhaustion. Cytokine secretion was modified after the longer training (T group), which decreased IFN-γ and IL-10 secretion but increased that of IL-6. Higher serum IgG concentrations after the longer training program were detected. In conclusion, the intensive training for 5 weeks changed the lymphocyte distribution among primary and secondary lymphoid tissues and modified their function.

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“…; Neves et al . ) and these responses are dependent upon the intensity and duration of exercise (Malm et al . ; Kawanishi et al .…”

Section: Introductionmentioning

confidence: 99%

Exercise‐evoked intramuscular neutrophil‐endothelial interactions support muscle performance and GLUT4 translocation: a mouse gnawing model study

Chaweewannakorn

Nyasha

Chen

et al. 2019

The Journal of Physiology

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Key pointsr Fractalkine receptor antagonist inhibited neutrophil recruitment to masseter muscles and exacerbated fatigability during masticatory activity.r Fractalkine-mediated neutrophil recruitment is required for both upregulation of myokines (CXCL1, interleukin-6) and enhanced GLUT4 translocation in response to masticatory activity.r Fractalkine and intercellular adhesion molecule-1 expression in endothelial cells increased in response to masticatory activity.r In vitro experiments demonstrated that contracting myotubes lack the ability to upregulate fractalkine but revealed that endothelial fractalkine upregulation is induced using a conditioned medium of contracting myotubes.Abstract Physical exercise stimulates neutrophil recruitment within working skeletal muscle, although its underlying mechanisms remain ill-defined. By employing a masticatory behaviour (gnawing) model, we demonstrate the importance of intramuscular paracrine and autocrine systems that are triggered by muscle contractile activity and reliant upon fractalkine/CX3CL1-mediated signals. These signals were revealed to be required for achieving proper GLUT4 translocation and glucose uptake to meet the glucose demands for fatigue alleviation. Specifically, fractalkine expression and neutrophil recruitment both increased in the masseter muscle tissues upon masticatory activity. Importantly, a fractalkine antagonist inhibited neutrophil accumulation and exacerbated fatigability during masticatory activity. We found that fractalkine-dependent neutrophil recruitment is required for both upregulation of myokines (i.e. CXCL1 and interleukin-6) and enhanced GLUT4 translocation in response to Chayanit Chaweewannakorn, DDS, PhD, obtained her doctoral degree in dental science from Tohoku University and her doctor of dental surgery degree from Chulalongkorn University. During her doctoral degree, she collaborated on publications on the skeletal muscle biology in response to exercise, especially the changes in immune components. Her major field interests are in the masticatory muscle responses related to temporomandibular disease and orofacial pain. Currently, she is a dentist and lecturer at C. Chaweewannakorn and others J Physiol 598.1 gnawing activity. Immunofluorescence analysis of masseter muscles demonstrated that fractalkine and intercellular adhesion molecule-1 expression are both upregulated in endothelial cells but not in myofibres. The in vitro exercise model further revealed that contractile activity failed to stimulate fractalkine upregulation in myotubes, implying that fractalkine is not a myokine (myofibre-derived factor). Nevertheless, endothelial fractalkine expression was markedly stimulated by a conditioned medium from the contracting myotubes. Moreover, intercellular adhesion molecule-1, a key adhesion molecule for neutrophils, was upregulated in endothelial cells by fractalkine. Taken together, our findings strongly suggest that endothelial fractalkine serves as a key factor for organizing a physiologically beneficial intramuscular mic...

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Acute effects of high- and low-intensity exercise bouts on leukocyte counts

Abstract: When the same participants were submitted to different exercise intensities, the acute and short-term effects of exercise on white blood cells were intensity-dependent immediately after exercise (i.e., lymphocytosis and monocytosis) and 2 hours after passive recovery (i.e., neutrophilia).

Cited by 74 publications

References 34 publications

Elevation of leukocyte counts is associated with an increase in the intensity and duration of exercise

Elevation of leukocyte counts is associated with an increase in the intensity and duration of exercise

Changes in Lymphocyte Composition and Functionality After Intensive Training and Exhausting Exercise in Rats

Exercise‐evoked intramuscular neutrophil‐endothelial interactions support muscle performance and GLUT4 translocation: a mouse gnawing model study

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