Acute Effects of Intermittent Pneumatic Compression on Popliteal Artery Blood Flow

Labropoulos, Nicos; Watson, William C.; Mansour, M. Ashraf; Kang, Seung-Min; Littooy, Fred N.; Baker, William H.

doi:10.1001/archsurg.133.10.1072

Cited by 35 publications

(42 citation statements)

References 24 publications

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“…Other authors reported that the improved emptying of lower extremity veins induced by SCDs increases the arteriovenous pressure gradient, with a marked increase of peak systolic and end-diastolic flow velocities, and reduction of the reverse-flow component, suggesting a decrease in PVP [20]. However, this finding does not necessarily contradict our results.…”

Section: Discussioncontrasting

confidence: 57%

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Systemic hemodynamic effects of sequential pneumatic compression of the lower limbs: a prospective study in healthy volunteers

Fanelli

Zasa

Baciarello

et al. 2008

Journal of Clinical Anesthesia

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Section: Discussioncontrasting

confidence: 57%

“…However, this finding does not necessarily contradict our results. Labropoulos et al [20] hypothesized that vasodilatation of distal arterial branches occurred as a result of brief (three sec), frequent, high-pressure compressions of the calf. Our SCD devices exerted longer, lighter compression to the whole lower limb region.…”

Section: Discussionmentioning

confidence: 99%

Systemic hemodynamic effects of sequential pneumatic compression of the lower limbs: a prospective study in healthy volunteers

Fanelli

Zasa

Baciarello

et al. 2008

Journal of Clinical Anesthesia

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“…An effect on arterial flow is indicated by a study on volunteers in whom, during foot-to-knee compression bandaging, an increase of lower leg pulsatile blood flow was observed by nuclear magnetic resonance (MR) flowmetry (22,23). Intermittent pneumatic foot and calf compression is also an effective therapeutic means to reduce the symptoms of venous insufficiency (4,17,19,26). Using color flow duplex imaging of the popliteal artery, Labropoulos et al (17) found increased blood flow in healthy volunteers during intermittent pneumatic foot and calf compression.…”

mentioning

confidence: 99%

“…Intermittent pneumatic foot and calf compression is also an effective therapeutic means to reduce the symptoms of venous insufficiency (4,17,19,26). Using color flow duplex imaging of the popliteal artery, Labropoulos et al (17) found increased blood flow in healthy volunteers during intermittent pneumatic foot and calf compression. Two studies (17,22) indicate that compression influences venous outflow as well as arterial inflow.…”

mentioning

confidence: 99%

External compression increases forearm perfusion

Bochmann¹,

Seibel²,

Haase³

et al. 2005

Journal of Applied Physiology

101

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Application of compression stockings to the lower extremities is a widely used therapeutic intervention to improve venous return, but there is little information about the effects of compression on local arterial perfusion. Therefore, we tested the hypothesis that a positive external pressure increases forearm perfusion. The relation of increasing external pressure induced by standardized compression to the arterial inflow and arterial flow reserve of the forearm was critically evaluated in a group of healthy young men (n = 9). Flow was measured with venous occlusion plethysmography after a 10-min application of six different stockings with compression pressure increasing from 13 to 23 mmHg. During compression, the arterial inflow increased significantly from 3.7 +/- 0.85 to 8.8 +/- 2.01 ml.min(-1).100 ml tissue(-1) (P < 0.001) and the arterial flow reserve increased from 17.7 +/- 4.7 to 28.3 +/- 7.0 ml.min(-1).100 ml tissue(-1). The flow increase was persistent after 3 h of constant application of external pressure and also during simultaneous low-intensity hand grip. Similar results obtained with occlusion plethysmography were seen with MRI. During the interventions, forearm temperature was unchanged, and the volunteers reported no discomfort. In conclusion, 1) arterial perfusion of the human forearm increases more than twofold during application of external compression over a pressure range of 13-23 mmHg, and 2) the result is interpreted as an autoregulatory response following the decrease of the vascular transmural pressure gradient.

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“…Several studies demonstrated, however, that the hemodynamic effects induced by EPC are not limited to changes in venous blood flow in the area of compression but, rather, exert a broader influence in the systemic circulation. For example, clinical studies revealed that EPC caused changes in central venous and pulmonary arterial pressures (41) and enhanced popliteal artery blood flow (6,24,42).…”

mentioning

confidence: 99%

Endothelial nitric oxide production during in vitro simulation of external limb compression

Dai

Tsukurov

Chen

et al. 2002

American Journal of Physiology-Heart and Circulatory Physiology

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External pneumatic compression (EPC) is effective in preventing deep vein thrombosis (DVT) and is thought to alter endothelial thromboresistant properties. We investigated the effect of EPC on changes in nitric oxide (NO), a critical mediator in the regulation of vasomotor and platelet function. An in vitro cell culture system was developed to simulate flow and vessel collapse conditions under EPC. Human umbilical vein endothelial cells were cultured and subjected to tube compression (C), pulsatile flow (F), or a combination of the two (FC). NO production and endothelial nitric oxide synthase (eNOS) mRNA expression were measured. The data demonstrate that in the F and FC groups, there is a rapid release of NO followed by a sustained increase. NO production levels in the F and FC groups were almost identical, whereas the C group produced the same low amount of NO as the control group. Conditions F and FC also upregulate eNOS mRNA expression by a factor of 2.08 ± 0.25 and 2.11 ± 0.21, respectively, at 6 h. Experiments with different modes of EPC show that NO production and eNOS mRNA expression respond to different time cycles of compression. These results implicate enhanced NO release as a potentially important factor in the prevention of DVT.

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Acute Effects of Intermittent Pneumatic Compression on Popliteal Artery Blood Flow

Cited by 35 publications

References 24 publications

Systemic hemodynamic effects of sequential pneumatic compression of the lower limbs: a prospective study in healthy volunteers

Systemic hemodynamic effects of sequential pneumatic compression of the lower limbs: a prospective study in healthy volunteers

External compression increases forearm perfusion

Endothelial nitric oxide production during in vitro simulation of external limb compression

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