Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and relationships with cardiorespiratory and subjective responses

Bouhlal, Sofia; Ellefsen, Kayla N.; Sheskier, Mikela B.; Singley, Erick; Pirard, Sandrine; Gorelick, David A.; Huestis, Marilyn A.; Leggio, Lorenzo

doi:10.1016/j.drugalcdep.2017.07.033

Cited by 38 publications

(28 citation statements)

References 64 publications

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“…Similarly, sCT attenuates the cocaine-induced locomotor stimulation and dopamine release in Nac shell ( Kalafateli et al, 2021 ), and decreases the amphetamine-induced locomotor simulation ( Twery et al, 1986 ; Clementi et al, 1996 ). In humans, cocaine reduces amylin in plasma ( Bouhlal et al, 2017 ; Angarita et al, 2021 ). Additionally to reward induced by addictive drugs, the amylinergic pathway regulates natural rewards like sexual behaviours ( Clementi et al, 1999 ) and hedonic feeding ( Mietlicki-Baase et al, 2013 ; Baisley and Baldo, 2014 ; Mietlicki-Baase et al, 2015 ; Mietlicki-Baase et al, 2017 ; Reiner et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Salmon Calcitonin Attenuates Some Behavioural Responses to Nicotine in Male Mice

et al. 2021

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The behavioural responses to nicotine involve appetite-regulatory hormones; however, the effects of the anorexigenic hormone amylin on reward-related behaviours induced by nicotine remain to be established. Previous studies have shown that the amylinergic pathway regulates behavioural responses to alcohol, amphetamine and cocaine. Here, we evaluated the effects of salmon calcitonin (sCT), an amylin and calcitonin receptor (CTR) agonist, on nicotine-induced locomotor stimulation and sensitisation as well as dopamine release in the nucleus accumbens (NAc) shell. Moreover, we investigated the effects of sCT on the acquisition and expression of nicotine-induced reward in the conditioned place preference (CPP) paradigm. Finally, we performed Western Blot experiments in an attempt to identify the levels of the amylin receptor components CTRa, CTRb, and RAMP1 in reward-related areas of mice responding differently to repeated injections of sCT and nicotine in the locomotor sensitisation test. We found that sCT blocked nicotine’s stimulatory and dopamine-releasing effects and prevented its ability to cause locomotor sensitisation. On the other hand, sCT did not alter nicotine-induced acquisition and expression of CPP. Lastly, sCT-nicotine treated mice from the locomotor sensitisation experiment displayed higher levels of total CTR, i.e. CTRa and CTRb together, in the reward-processing laterodorsal tegmental area (LDTg) of the brain compared to mice treated with vehicle-nicotine. Overall, the present data reveal that activation of CTR or/and amylin receptors attenuates certain nicotine-induced behaviours in male mice, further contributing to the understanding of appetite-regulatory peptides in reward regulation.

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Section: Discussionmentioning

confidence: 99%

Salmon Calcitonin Attenuates Some Behavioural Responses to Nicotine in Male Mice

et al. 2021

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“…Accordingly, treatment with sCT has been reported to block amphetamine-induced locomotor stimulation in rats [40]. Moreover, a recent study showed a trend of decreased amylin levels after cocaine intravenous injection in cocaine-experienced users [41].…”

Section: Discussionmentioning

confidence: 99%

An amylin analogue attenuates alcohol-related behaviours in various animal models of alcohol use disorder

Kalafateli

Vallöf

Colombo

et al. 2019

Neuropsychopharmacol.

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Recent findings have identified salmon calcitonin (sCT), an amylin receptor agonist and analogue of endogenous amylin, as a potential regulator of alcohol-induced activation of the mesolimbic dopamine system and alcohol consumption. Providing that the role of amylin signalling in alcohol-related behaviours remains unknown, the present experiments investigate the effect of sCT on these behaviours and the mechanisms involved. We showed that repeated sCT administration decreased alcohol and food intake in outbred rats. Moreover, single administration of the potent amylin receptor antagonist, AC187, increased short-term alcohol intake in outbred alcohol-consuming rats, but did not affect food intake. Acute administration of sCT prevented relapse-like drinking in the “alcohol deprivation effect” model in outbred alcohol-experienced rats. Additionally, acute sCT administration reduced operant oral alcohol self-administration (under the fixed ratio 4 schedule of reinforcement) in selectively bred Sardinian alcohol-preferring rats, while it did not alter operant self-administration (under the progressive ratio schedule of reinforcement) of a highly palatable chocolate-flavoured beverage in outbred rats. Lastly, we identified differential amylin receptor expression in high compared to low alcohol-consuming rats, as reflected by decreased calcitonin receptor and increased receptor activity modifying protein 1 expression in the nucleus accumbens (NAc) of high consumers. Collectively, our data suggest that amylin signalling, especially in the NAc, may contribute to reduction of various alcohol-related behaviours.

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“…The antagonistic relationship between GLP-1 and cocaine is well supported by preclinical work, as shown above. However, a study finding reduced serum GLP-1 levels in human participants following intravenous cocaine administration shows that this relationship may be bidirectional (Bouhlal et al, 2017).…”

Section: Psychostimulantsmentioning

confidence: 99%

GLP-1: Molecular mechanisms and outcomes of a complex signaling system

Smith

Hackett

Galli

et al. 2019

Neurochemistry International

102

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Meal ingestion provokes the release of hormones and transmitters, which in turn regulate energy homeostasis and feeding behavior. One such hormone, glucagon-like peptide-1 (GLP-1), has received significant attention in the treatment of obesity and diabetes due to its potent incretin effect. In addition to the peripheral actions of GLP-1, this hormone is able to alter behavior through the modulation of multiple neural circuits. Recent work that focused on elucidating the mechanisms and outcomes of GLP-1 neuromodulation led to the discovery of an impressive array of GLP-1 actions. Here, we summarize the many levels at which the GLP-1 signal adapts to different systems, with the goal being to provide a background against which to guide future research.

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Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and relationships with cardiorespiratory and subjective responses

Cited by 38 publications

References 64 publications

Salmon Calcitonin Attenuates Some Behavioural Responses to Nicotine in Male Mice

Salmon Calcitonin Attenuates Some Behavioural Responses to Nicotine in Male Mice

An amylin analogue attenuates alcohol-related behaviours in various animal models of alcohol use disorder

GLP-1: Molecular mechanisms and outcomes of a complex signaling system

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