Acute effects of intravenous phenytoin on the frequency of inter‐ictal spikes in man.

Abstract

1 Phenytoin was administered intravenously to six adult epileptic patients in doses ranging from 500-1000 mg (equivalent to 5.6 mg/kg-20 mg/kg body weight). 2 A significant decrease in the frequency of inter-ictal spikes in the EEG was seen and this effect was most marked 10-20 min after the infusion, when the mean spike count was reduced to 27% (s.d. 17%) of the control (P < 0.05). 3 In one subject the decrease in inter-ictal spikes coincided with a decrease in fit frequency. 4 Adverse reactions affecting the vestibular system occurred in three patients at doses of 15-20 mg/kg. No cardiovascular complications were observed in any subject. 5 The overall results suggest that doses of 7.5-10 mg/kg would be sufficient to significantly reduce the frequency of inter-ictal spikes in the EEG.

Comparison of Midazolam and Diazepam by the Intramuscular Route for the Control of Seizures in a Mouse Model of Status Epilepticus

“…administration is not feasible. Although interictal spike suppression is not quite the same as seizure suppression, it is noteworthy that this is an action shared by PHT (Milligan et al, 1983). Thus, our data supports evaluation of MDL administered i.m.…”

Effects of antiepileptic drugs on interictal epileptiform discharges in focal epilepsies: an update on current evidence

“…In a single-blind, placebo-controlled trial in six patients with drug-resistant focal epilepsy, acute intravenous administration of 500-1000 mg of PHT produced a significant decrease in IEDs frequency [21], which was evident from up to 90 min after the infusion [21].…”

“…Single-blind, placebocontrolled, crossover 10 min EEG before and each 3 h for 7 times after drug administration PHT reduces IEDs [21] Kellaway et al No effect of LCM on IEDs [49] Giorgi et al [18] Gobbi et al PHT > sulthiame; no statistically significant results [23] Jawad et al Effects of antiepileptic drugs on interictal epileptiform discharges in focal epilepsies Review informahealthcare.com EEG investigations during therapy with carbamazepine' [14]. Actually, reconsidering these reports according to current knowledge, IEDs worsening was limited to patients with IGE, a phenomenon repeatedly confirmed thereafter [15].…”

Phenytoin‐Induced Seizures: A Paradoxical Effect at Toxic Concentrations in Epileptic Patients

“…A review of the literature (Schreiner, 1958;Roseman, 1%1;Levy and Fenichel, 1%5; Patel and Crichton, 1%8; Lascelles et al, 1970;Troupin and Ojemann, 1975;Meistrup-Larsen et al, 1979;Milligan et a]., 1983;Stilman and Masdeu, 1985;Zwarts and Sie, 1985;Lerman, 1986) reveals, however, that this correlation is not supported by rigorous clinical observations or statistically significant data. A review of the literature (Schreiner, 1958;Roseman, 1%1;Levy and Fenichel, 1%5; Patel and Crichton, 1%8; Lascelles et al, 1970;Troupin and Ojemann, 1975;Meistrup-Larsen et al, 1979;Milligan et a]., 1983;Stilman and Masdeu, 1985;Zwarts and Sie, 1985;Lerman, 1986) reveals, however, that this correlation is not supported by rigorous clinical observations or statistically significant data.…”