Acute Effects of Oral Glucose Loading on the Renin-Angiotensin-Aldosterone System in Patients with Chronic Renal Disease

Abstract

To determine the changes of the glucose-induced renin-angiotensin-aldosterone system in chronic renal disease, a standard oral glucose loading test (75g) was performed in patients with chronic glomerulonephritis (CGN) (n = 12) and compared with control subjects (10). Glucose loading resulted in a significant decrease of serum aldosterone as well as increases of blood glucose and insulin similarly in both CGN and C. However, the suppression of aldosterone was statistically milder in CGN than in C (p < 0.05). In contrast, significant elevations of plasma renin activity were observed in CGN at 60 and 120 min, but not in C after glucose loading. Urinary sodium excretion after glucose ingestion was lower in CGN than in C. These data demonstrated that the glucose-induced renin-angiotensin-aldosterone system in patients with chronic renal disease differed from that in healthy subjects.

Insulin and Mineralocorticoids Influence on Extrarenal Potassium Metabolism in Chronic Hemodialysis Patients

“…High aldosterone levels were noted in G2 patients serving as controls with normal potassium levels. Chronic glomerulonephritis was the main cause of their primary renal disease and high aldosterone and renin levels, suggestive of secondary hyperaldosteronism due to autonomous renin secretion in this renal disease, as other investigators have found (13,14) could explain this phenomenon.…”