Acute Effects of Orally Administered Levamisole on Random Monocyte Motility and Chemotaxis in Man&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

Eleven healthy volunteers (six men, five women) and twelve cancer patients (six men, six women) were given single oral doses (2.5 mg/kg body weight) of levarnisole, an immunostimulant agent. In a second experiment eleven healthy et volunteers (six men, five women) and twelve cancer patients (six men, six women) were given single oral doses (5 rug/kg body weight) of levamisole. The levamisole concentrations in plasma (24 h blood sampling) were measured by gas chromatography after extraction. A mono-compartment open model was proposed, and some parameters were calculated. The main results from these two experiments are: the drug was absorbed well, the peak levels of levamisole in the plasma were reached after 1.0 -2.0 hrs and ranged between 0,8 l!g and 1.6 ug/ml with the 2.5 mg and 5 mg/kg body weight doses respectively (concentrations required in vitro to produce an immunological effect); the plasma half-life of levamisole calculated from the decline in the concentration curves varied between 3.3 hand 5.1 h; the absorbed fractions were 0.7 and clearance 310 ml/min; twenty-four hours after medication, the levamisole concentrations in plasma were only 6 % of the peak levels.The interindividual variability in the parameters seemed to be very important; and it may be concluded that the immunostimulant effect critically depends on the dose of the drug. A minimum effective plasma concentration is necessary to trigger its effects, on the other hand high concentrations may produce an immunosuppressive effect.

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A phase I study of 5-fluorouracil, leucovorin and levamisole

Cleary

Arzoomanian

Alberti

et al. 1997

Cancer Chemotherapy and Pharmacology

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Acute Effects of Orally Administered Levamisole on Random Monocyte Motility and Chemotaxis in Man<xref ref-type="fn" rid="FN2">2</xref>

Cited by 8 publications

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In vitro assays of immunocompetence in patients with lung cancer treated with levamisole

In vitro assays of immunocompetence in patients with lung cancer treated with levamisole

Pharmacokinetics of Levamisole in healthy subjects and cancer patients

A phase I study of 5-fluorouracil, leucovorin and levamisole

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