Acute effects of post-absorptive and postprandial moderate exercise on markers of inflammation in hyperglycemic individuals

Nygaard, Håvard; Falch, Gunnar Slettaløkken; Whist, Jon Elling; Hollan, Ivana; Ellefsen, Stian; Holmboe‐Ottesen, Gerd; Rønnestad, Bent R.; Høstmark, Arne T.

doi:10.1007/s00421-017-3576-2

Cited by 9 publications

(13 citation statements)

References 33 publications

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“…In women, serum sVCAM-1 is inversely correlated with visceral adipose tissue [41]. In persons with hyperglycemia, moderate exercise was shown to increase sVCAM-1 [42]. …”

Section: Discussionmentioning

confidence: 99%

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Nowak

Wojsyk‐Banaszak

Mądry

et al. 2017

Lung

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PurposeAs life expectancy in cystic fibrosis (CF) increases, questions regarding its potential impact on cardiovascular health arise. Soluble vascular cell adhesion molecule 1 (sVCAM-1), P-selectin (sP-selectin) are proposed as biomarkers of cardiovascular disease. We aimed to: compare their concentrations in clinically stable CF patients and healthy subjects (HS) and verify whether they independently correlate with CF characteristics.MethodsSerum sVCAM-1 and sP-selectin levels were measured using ELISA. CF was characterized using: forced expiratory volume in 1 s, exocrine pancreatic and CF-related liver disease status, Pseudomonas aeruginosa colonization, serum high-sensitivity C-reactive protein, and body mass index (BMI). CFTR genotypes were classified as severe (classes I and II) or other.Results108 CF patients and 51 healthy subjects volunteered for the study. In the CF group BMI was lower (median [IQR]: 20.5 kg/m2 [18.4–22.2] vs. 21.6 kg/m2 [19.9–23.4], p = 0.02) and hsCRP levels were higher (3.6 mg/L [1.1–7.1] vs. 0.5 mg/dL [0.3–1.0], p < 10−10). While sVCAM-1 concentrations were greater in CF patients (1018 ng/mL [851–1279] vs. 861 ng/mL [806–979], p < 10−4), sP-selectin levels did not differ (155 ng/mL [129–188] vs. 156 ng/mL [144–177], p = 0.48). None of the multivariable regression models was valid for the prediction of sVCAM-1 and sP-selectin in CF.ConclusionsWe found higher sVCAM-1 concentrations in CF patients than in healthy subjects, which were not explained by CF characteristics. Further research is required to check whether sVCAM-1 is a marker of microangiopathy in CF.

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“…In women, serum sVCAM-1 is inversely correlated with visceral adipose tissue [41]. In persons with hyperglycemia, moderate exercise was shown to increase sVCAM-1 [42]. …”

Section: Discussionmentioning

confidence: 99%

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Nowak

Wojsyk‐Banaszak

Mądry

et al. 2017

Lung

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“…In fact, a growing body of evidence suggests that the interaction between exercise timing and the timing of food intake may play an important role in the modulation of the circadian clock and the prevention of metabolic diseases, such as T2DM 65 . In line with this, a single bout of postprandial treadmill walking, compared with treadmill walking in a fasted state, further reduced glycemic excursions and glycemic variability, measured by CGM, over the next 22 h in 12 patients with T2DM 66 . A randomized crossover trial including 77 healthy individuals revealed that different exercise bouts performed early after meal, but not in the fasted state, led to significant reductions in postprandial glycemia 67 .…”

Section: The Role Of Exercise Timing In Metabolic Health: Clinical Im...mentioning

confidence: 74%

“…65 In line with this, a single bout of postprandial treadmill walking, compared with treadmill walking in a fasted state, further reduced glycemic excursions and glycemic variability, measured by CGM, over the next 22 h in 12 patients with T2DM. 66 A randomized crossover trial including 77 healthy individuals revealed that different exercise bouts performed early after meal, but not in the fasted state, led to significant reductions in postprandial glycemia. 67 Also, a trial conducted in 54 healthy postmenopausal women demonstrated that 2-h moderate-intensity acute exercise performed 1 h after meals was more effective in reducing insulin resistance than exercise performed 1 h before meals.…”

Section: Type 2 Diabetes Mellitusmentioning

confidence: 99%

Effects of exercise timing on metabolic health

et al. 2023

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SummaryThe increasing prevalence of metabolic syndrome is associated with major health and socioeconomic consequences. Currently, physical exercise, together with dietary interventions, is the mainstay of the treatment of obesity and related metabolic complications. Although exercise training includes different modalities, with variable intensity, duration, volume, or frequency, which may have a distinct impact on several characteristics related to metabolic syndrome, the potential effects of exercise timing on metabolic health are yet to be fully elucidated. Remarkably, promising results with regard to this topic have been reported in the last few years. Similar to other time‐based interventions, including nutritional therapy or drug administration, time‐of‐day‐based exercise may become a useful approach for the management of metabolic disorders. In this article, we review the role of exercise timing in metabolic health and discuss the potential mechanisms that could drive the metabolic‐related benefits of physical exercise performed in a time‐dependent manner.

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“…There was also no beneficial effect of either exercise condition on postprandial glucose responses in comparison with the no-exercise condition. This is perhaps unsurprising, given that studies have demonstrated that 60 min of treadmill walking in the fasted state has no effect on glucose responses to a mixed-macronutrient meal in persons with obesity (37) and hyperglycemia (40). An increased rate of appearance of glucose from the liquid meal during the initial 3-h postexercise period is likely to be the reason for the lack of difference in postprandial glucose, offsetting the increased clearance rate (41).…”

Section: Discussionmentioning

confidence: 99%

A Single Bout of Upper-Body Exercise Has No Effect on Postprandial Metabolism in Persons with Chronic Paraplegia

Farrow¹,

Maher²,

Nightingale³

et al. 2021

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose The acute effects of a single bout of upper-body exercise on postprandial metabolism in persons with spinal cord injury are currently not well understood. The primary aim of this study was to evaluate the effects of a single bout of upper-body high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) in comparison with a no-exercise control (REST) condition on postprandial metabolic responses in persons with chronic paraplegia. Methods Ten participants (eight males, two females; age, 49 ± 10 yr; time since injury, 22 ± 13 yr) with chronic paraplegia took part in a randomized crossover study, consisting of three trials: HIIE (8 × 60 s at 70% peak power output [P PEAK ]), MICE (25 min at 45% P PEAK ), and REST, at least 3 d apart. Exercise was performed in the fasted state, and participants consumed a mixed-macronutrient liquid meal 1-h postexercise. Venous blood and expired gas samples were collected at regular intervals for 6-h postmeal consumption. Results There were no significant differences in postprandial incremental area under the curve for triglycerides ( P = 0.59) or glucose ( P = 0.56) between conditions. Insulin incremental area under the curve tended to be lower after MICE (135 ± 85 nmol·L −1 per 360 min) compared with REST (162 ± 93 nmol·L −1 per 360 min), but this did not reach statistical significance ( P = 0.06, d = 0.30). Participants reported a greater fondness ( P = 0.04) and preference for HIIE over MICE. Conclusions After an overnight fast, a single bout of upper-body exercise before eating has no effect on postprandial metabolism in persons with chronic paraplegia, irrespective of exercise intensity. This suggests that alternative exercise strategies may be required to stimulate postprandial substrate oxidation for this population.

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Acute effects of post-absorptive and postprandial moderate exercise on markers of inflammation in hyperglycemic individuals

Abstract: Moderate exercise increases sVCAM-1 in hyperglycemic individuals, whereas it does not affect CRP.

Cited by 9 publications

References 33 publications

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

Effects of exercise timing on metabolic health

A Single Bout of Upper-Body Exercise Has No Effect on Postprandial Metabolism in Persons with Chronic Paraplegia

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