Acute effects of sono-activated photocatalytic titanium dioxide nanoparticles on oral squamous cell carcinoma

Nejad, S. Moosavi; Takahashi, Hiromasa; Hosseini, Hamid Reza Madaah; Watanabe, Akira; Endo, Hitomi; Narihira, Kyoichi; Kikuta, Toshihiro; Tachibana, Katsuro

doi:10.1016/j.ultsonch.2016.02.026

Cited by 44 publications

(26 citation statements)

References 38 publications

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“…Hybrid NPS exerted the highest antiangiogenic activity [63]. Sonodynamic therapy (SDT) consisted in replacement of light in PDT with ultrasound and is emerging as a possible treatment for oral cavity SCC [64]. Moosavi Nejad et al [64] evaluated the effects of photocatalytic TiO 2 NPs combined with high intensity focused ultrasound (HIFU) on oral cavity SCC cells and subcutaneous xenograft models.…”

Section: Magnetic Nps For Other Applicationsmentioning

confidence: 99%

Nanomedicine, an emerging therapeutic strategy for oral cancer therapy

et al. 2018

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Oral cavity and oropharyngeal carcinomas (oral cancer) represents a significant cause of morbidity and mortality. Despite efforts in improving early diagnosis and treatment, the 5-year survival rate of advanced stage of the disease is less than 63%. The field of nanomedicine has offered promising diagnostic and therapeutic advances in cancer. Indeed, several platforms have been clinically approved for cancer therapy, while other promising systems are undergoing exploration in clinical trials. With its ability to deliver drugs, nucleic acids, and MRI contrast agents with high efficiency, nanomedicine platforms offer the potential to improve drug efficacy and tolerability. The aim of the present mini-review is to summarize the current preclinical status of nanotechnology systems for oral cancer therapy. The nanoplatforms for delivery of chemopreventive agents presented herein resulted in significantly higher anti-tumor activity than free forms of the drug, even against a chemo-resistant cell line. Impressive results have also been obtained using nanoparticles to deliver chemotherapeutics, resulting in reduced toxicity both in vitro and in vivo. Nanoparticles have also led to improvements in efficacy of photodynamic therapies through the development of targeted magnetic nanoparticles. Finally, gene therapy using nanoparticles demonstrated promising results specifically with regards to inhibition of gene expression. Of the few in vivo studies that have been reported, many of these used animal models with several limitations, which will be discussed herein. Lastly, we will discuss several future perspectives in oral cancer nanoparticle-based therapy and the development of appropriate animal models, distinguishing between oral cavity and oropharyngeal carcinoma.

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Section: Magnetic Nps For Other Applicationsmentioning

confidence: 99%

Nanomedicine, an emerging therapeutic strategy for oral cancer therapy

et al. 2018

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“…In comparison with UV or NIR radiation, US penetrates tissues much more effectively as it reaches deeper depths tumor cells. The introduction of sonosensitizers into cancer cells and their subsequent exposure to US in order to generate ROS is the underlying factor of SDT [199, 200] (Fig. 2).…”

Section: Reviewmentioning

confidence: 99%

“…Moosavi Nejda et al [200] examined in vitro the influence of the US-excited TiO 2 NPs (100 μg mL −1 ) on the viability of human oral squamous carcinoma cells (HSC-2 line). The authors proved the increased intensity of US (20, 32, 55, 73 W cm −2 ) and the prolonged sonication period (0.1, 1.0, 3.0 s) enhanced the damage ratio in the human HSC-2 cells, finally leading to their necrosis at the conditions of 73 W cm −2 and 3 s. Yamaguchi et al [183] believe that TiO 2 NP-based cancer therapies will soon become a valuable tool in fighting malignant gliomas.…”

Section: Reviewmentioning

confidence: 99%

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

2017

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Cancer has become a global problem. On all continents, a great number of people are diagnosed with this disease. In spite of the progress in medical care, cancer still ends fatal for a great number of the ill, either as a result of a late diagnosis or due to inefficiency of therapies. The majority of the tumors are resistant to drugs. Thus, the search for new, more effective therapy methods continues. Recently, nanotechnology has been attributed with big expectations in respect of the cancer fight. That interdisciplinary field of science creates nanomaterials (NMs) and nanoparticles (NPs) that can be applied, e.g., in nanomedicine. NMs and NPs are perceived as very promising in cancer therapy since they can perform as drug carriers, as well as photo- or sonosensitizers (compounds that generate the formation of reactive oxygen species as a result of either electromagnetic radiation excitation with an adequate wavelength or ultrasound activation, respectively). Consequently, two new treatment modalities, the photodynamic therapy (PDT) and the sonodynamic therapy (SDT) have been created. The attachment of ligands or antibodies to NMs or to NPs improve their selective distribution into the targeted organ or cell; hence, the therapy effectiveness can be improved. An important advantage of the targeted tumor treatment is lowering the cyto- and genotoxicity of active substance towards healthy cells. Therefore, both PDT and SDT constitute a valuable alternative to chemo- or radiotherapy. The vital role in cancer eradication is attributed to two inorganic sensitizers in their nanosized scale: titanium dioxide and zinc oxide.

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“…68 On squamous carcinoma HSC-2, TiO 2 nanoparticles were successfully used in association with short high-intensity exposure (0.1-3 seconds at 20 to 73 W/cm 2 ). 69 Titanium dioxide can also be bound with gold as hydrophilized gold-TiO 2 nanocomposites. 70 These are efficient sensitizers that entirely suppressed tumor growth in vivo.…”

Section: Limitations and Perspectivesmentioning

confidence: 99%

Sonodynamic Therapy: Advances and Challenges in Clinical Translation

Lafond

Yoshizawa

Umemura

2018

J of Ultrasound Medicine

126

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Sonodynamic therapy (SDT) consists of the synergetic interaction between ultrasound and a chemical agent. In SDT, the cytotoxicity is triggered by ultrasonic stimuli, notably through cavitation. The unique features of SDT are relevant in the clinical context more than ever: the need for efficacy, accuracy, and safety while being noninvasive and preserving the patient's quality of life. However, despite the promising results of this technique, only a few clinical reports describe the use of SDT. The objective of this article is to provide an extensive overview of the clinical and preclinical research conducted in vivo on SDT, to identify the limitations, and to detail the developed strategies to overcome them.

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Acute effects of sono-activated photocatalytic titanium dioxide nanoparticles on oral squamous cell carcinoma

Cited by 44 publications

References 38 publications

Nanomedicine, an emerging therapeutic strategy for oral cancer therapy

Nanomedicine, an emerging therapeutic strategy for oral cancer therapy

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

Sonodynamic Therapy: Advances and Challenges in Clinical Translation

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