Acute Effects of Synthetic Porcine Calcitonins on the Renal Excretion of Magnesium, Inorganic Phosphate, Sodium and Potassium

Sp, Nielsen; Buchanan-Lee, B.; Ew, Matthews; Jm, Moseley; Cc, Williams

doi:10.1677/joe.0.0510455

Cited by 19 publications

(9 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…mg/100 ml 9.7 ± 0.6 9.7 ± 0.5 8.9 ± 1.2 8.9 ± 0.2 6.6 ± 0. given saline alone. Although other investi gators [12][13][14]16,18] have described a natri uretic effect of CT, we were unable to demon strate such in our studies. The predominant effect of CT was noted in the pattern of urinary calcium and phosphate excretion as has al ready been reported [9,17], This effect was seen in intact and TPTX animals in which the plasma concentrations of calcium and phos phate decreased following CT infusion.…”

Section: Intact Ratcontrasting

confidence: 62%

“…An increased excretion of calcium [12] and potassium [12, 13] was found by some workers, but the oppo site result has been demonstrated by others [15,16]. Many others [12][13][14]16] found an increas ed excretion of sodium in accordance with an increased urine volume. However, there is ap parently no documentation of definite expla nations for the excretion of renal electrolytes by CT.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acute Effects of Salmon Calcitonin on Renal Electrolyte Excretion in Intact, Thyroparathyroidectomized and Sulfacetylthiazole-Induced Uremic Rats

Kawamura¹,

Daizyo²,

Hosokawa³

et al. 1978

Nephron

View full text Add to dashboard Cite

Acute effects of salmon calcitonin (CT) on renal electrolyte excretion were investigated in intact, thyroparathyroidectomized (TPTX) and uremic rats. Glomerular filtration rate did not change during CT infusion and there was no volume expansion in any experimental group. Plasma calcium levels gradually fell below the control period in each experimental group. Urinary calcium excretion increased at the early period in both intact and TPTX rats but fell below the control period with the continuous infusion of CT. In uremic rats, a decrease in plasma calcium was followed by a decrease in calcium excretion. Plasma phosphate gradually decreased and simultaneously measured phosphate excretion increased in both intact and TPTX rats. In uremic rats, however, there was no change in phosphate excretion and only a slight decrease of plasma phosphate. Phosphaturia is the result of the predominant renal action of CT and occurs even when the filtered load of phosphate decreases. In uremic animals, there appears to be a resistance to exogenous CT which manifests itself by the absence of natriuretic, calciuric and phosphaturic responses.

show abstract

Section: Intact Ratcontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Acute Effects of Salmon Calcitonin on Renal Electrolyte Excretion in Intact, Thyroparathyroidectomized and Sulfacetylthiazole-Induced Uremic Rats

Kawamura¹,

Daizyo²,

Hosokawa³

et al. 1978

Nephron

View full text Add to dashboard Cite

show abstract

“…0-1 u./100 g rat, calcitonin has been claimed to be natriuretic (Nielsen, Buchanan-Lee, Mathews, Moseley & Williams, 1971). Several other polypeptide hormones viz.…”

Section: Discussionmentioning

confidence: 99%

The physiological role of calcitonin assessed through chronic calcitonin deficiency in rats

Kumar¹,

Sturtridge²

1973

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. An attempt was made to assess the physiological role of calcitonin by producing its prolonged deficiency in rats.2. Three groups of young rats viz. (I) sham-operated controls, (II) thyroidectomized with thyroxine replacement and (III) thyroidectomized with thyroxine as well as calcitonin replacement, all with parathyroid autografts, were studied for 5 weeks. Groups II and III showed impaired Ca tolerance and group II also showed significant reduction in total (organic and inorganic) mass of femora as compared to group I.3. Three similar groups of old mature rats were studied as under (2) for 9 weeks. Groups II and III in this case showed no significant changes as compared to group I.4. In intact mature rats, Ca tolerance is impaired, thyroid content of calcitonin is high and the hypocalcaemic action of calcitonin is much reduced as compared to intact young rats.5. It is concluded that calcitonin plays a useful but non-essential role in Ca metabolism and bone development of young growing rats. Its function, if any, in mature rats on a normal diet remains doubtful.

show abstract

“…Calcitonin does not act directly on dog kidney to cause natriuresis (present study, 23). On the other hand, in rats, salmon (24), and porcine (25,26), calcitonin increases sodium excretion. In these cases, calcitonin may possibly have an action on the kidneys since intact and TPTX rats responded to calcitonin with a significant increase in sodium excretion.…”

Section: Effect Of Ect On Renal Hemodynamicsmentioning

confidence: 97%

Effects of elcatonin on plasma and urine electrolytes in infant beagles.

Miyazaki¹,

Okunishi²,

Toda³

1982

Jpn.J.Pharmacol

View full text Add to dashboard Cite

Abstract-The effects of elcatonin (ECT) on the renal hemodynamics and electrolyte levels in plasma and urine were investigated in anesthetized infant beagles (3 months old) and adult beagles (9-10 months old). Intra venous injections of 50 M RC U/kg ECT did not alter the systemic blood pressure, renal blood flow, glomerular filtration rate, and urine flow in intact puppies as well as in puppies and adult dogs subjected to extirpation of the thyroid and parathyroid glands (TPTX). One hundred and twenty min after ECT injection, the plasma calcium concentration decreased by 1.06±0.15 mEq/I in intact puppies and 0.94±0.10 mEq/I in TPTX puppies, but decreased only by 0.38±0.22 mEq/I in adult TPTX dogs.The urinary calcium excretion decreased in all the puppies. The plasma phosphorus concentration decreased by 1.02±0.10 mg/dl, and the phosphorus excretion rate increased 63.6±26.4% in intact puppies; whereas the plasma phos phorus and phosphorus excretion were not altered in TPTX puppies. Diuresis and natriuresis were not obtained.These data suggest that the acute hypocalcemic effect of ECT is dependent on age and is not associated with its action on kidneys.

show abstract

Acute Effects of Synthetic Porcine Calcitonins on the Renal Excretion of Magnesium, Inorganic Phosphate, Sodium and Potassium

Cited by 19 publications

References 18 publications

Acute Effects of Salmon Calcitonin on Renal Electrolyte Excretion in Intact, Thyroparathyroidectomized and Sulfacetylthiazole-Induced Uremic Rats

Acute Effects of Salmon Calcitonin on Renal Electrolyte Excretion in Intact, Thyroparathyroidectomized and Sulfacetylthiazole-Induced Uremic Rats

The physiological role of calcitonin assessed through chronic calcitonin deficiency in rats

Effects of elcatonin on plasma and urine electrolytes in infant beagles.

Contact Info

Product

Resources

About