Acute effects of time-restricted feeding in low-income women with obesity placed on hypoenergetic diets: Randomized trial

Pureza, Isabele Rejane de Oliveira Maranhão; Melo, Ingrid Sofia Vieira de; Macêna, Mateus de Lima; Praxedes, Dafiny Rodrigues Silva; Vasconcelos, Laí­s Gomes Lessa; Júnior, André Eduardo da Silva; Florêncio, Telma M. M. T.; Bueno, Nassib Bezerra

doi:10.1016/j.nut.2020.110796

Cited by 44 publications

(50 citation statements)

References 34 publications

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“…In addition, TRF reduced insulin levels at multiple time points during OGTT in men with prediabetes [12]. Some other randomized clinical trials, however, confirmed that TRF did not change 24-h mean or peak insulin level, and did not alter insulin levels during a 2-h OGTT [14-16]. In consensus with part of the previous studies, in this experiment, TRF reduced insulin level in light phase.…”

Section: Discussionsupporting

confidence: 81%

“…In terms of insulin and GH, results from human studies showed that TRF could reduce insulin levels in several time points and the mean [12, 13]. However, some randomized clinical trials indicated that TRF had no effect on 24-h mean or peak insulin levels and insulin levels during a 2-h oral glucose tolerance test (OGTT) [14-16]. Different intervention time and time range of TRF may lead to inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

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Time-Restricted Feeding Restored Insulin-Growth Hormone Balance and Improved Substrate and Energy Metabolism in MC4RKO Obese Mice

Wang

Huang

et al. 2021

Neuroendocrinology

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Background Dysregulation of metabolic regulatory hormones often occurs during the progress of obesity. Key regulatory hormone Insulin-GH balance has recently been proposed to maintain metabolism profiles. Time-restricted feeding (TRF) is an effective strategy against obesity without detailed research on pulsatile GH releasing patterns. Methods TRF was performed in an over-eating MC4RKO obese mouse model using normal food. Body weight and food intake were measured. Series of blood samples were collected for 6 h pulsatile GH profile, glucose tolerance test and insulin tolerance test at 5, 8, and 9 weeks of TRF, respectively. Indirect calorimetric recordings were performed by Phenomaster system at 6 weeks for 1 week and body composition was measured by Nuclear magnetic resonance spectroscopy (NMR). Substrate and energy metabolism related gene expression were measured in terminal liver and subcutaneous white adipose tissues. Results TRF increased pulsatile GH secretion in dark phase and suppressed hyperinsulinemia in MC4RKO obese mice to reach a reduced insulin/GH ratio. This was accompanied by the improvement in insulin sensitivity, metabolic flexibility, glucose tolerance and decreased glucose fluctuation, together with appropriate modification of gene expression involved in substrate metabolism and adipose tissue browning. NMR measurement showed that TRF decreased fat mass but increased lean mass. Indirect calorimeter recording indicated that TRF decreased the respiratory exchange ratio (RER) reflecting consumption of more fatty acid in energy production in light phase and increased the oxygen consumption during activities in dark phase. Conclusions TRF effectively decreases hyperinsulinemia and restores pulsatile GH secretion in the overeating obese mice with significant improvement in substrate and energy metabolism and body composition without reducing total caloric intake.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Time-Restricted Feeding Restored Insulin-Growth Hormone Balance and Improved Substrate and Energy Metabolism in MC4RKO Obese Mice

Wang

Huang

et al. 2021

Neuroendocrinology

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“…Though no data are available in youth, adult TLE research supports relatively high levels of acceptability and adherence. In a recent 21-day randomized controlled trial ( 22 ), women with obesity assigned to a hypoenergetic diet with or without TLE12 did not differ in self-reported hunger or difficulty adhering to the protocol, and there was no loss to follow up in the TLE12 group. In a study implementing TLE10 and using a validated app to track dietary intake ( 20 ), the eating window of 19 adults with metabolic syndrome was reduced from 15.1h to 10.8 h, and participants ate outside their eating window on only 7.1% of days, indicating high adherence to the protocol.…”

Section: Discussionmentioning

confidence: 96%

Acceptability of Time-Limited Eating in Pediatric Weight Management

et al. 2022

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BackgroundAdherence to dietary interventions is a significant barrier in the treatment of childhood obesity. Time-limited eating (TLE) is a simple dietary approach that limits food intake to a given number of consecutive hours per day, but parental and youth acceptability of TLE in youth with obesity is unknown. This study explored the feasibility of utilizing TLE among parents and youth attending pediatric weight management (PWM).MethodsMembers of COMPASS (Childhood Obesity Multi-Program Analysis and Study System) developed a survey to assess the acceptability of TLE in families attending PWM, which included patient characteristics, current diet and sleep schedules, and interests in trying TLE. The survey was administered electronically via REDCap or manually to parents of patients between the ages of 8-17 years old and to patients 11-17 years old attending one of five PWM practices in the COMPASS network.ResultsPatients (n=213) were 13.0 ± 2.5 years old, 58% female, 52% White, 22% Black, 17% Hispanic/Latino, and 47% reported a diagnosed psychological disorder. On average, parents reported their child’s daily eating spanned 12.5 ± 1.9 hours (7:35am - 8:05pm) and included 5.6 ± 1.6 eating bouts (meals + snacks). Most parents reported being likely to try TLE ≤12 hours/d (TLE12: 66%), which was similar to the likelihood of following a nutrient-balanced diet (59%). Likelihood was lower for TLE ≤10 hours/d (TLE10: 39%) or ≤8 hours/d (TLE8: 26%) (p<0.001 for both). Interest in TLE was not consistently related to patient age, sex, or ethnicity, but was lower in patients with a psychiatric diagnosis vs. no diagnosis (TLE8: 19% vs. 32%; p=0.034). Patients of parents who reported being likely to try TLE, compared to those unlikely to try TLE, had shorter eating windows (p<0.001) and ate fewer snacks (p=0.006).ConclusionsTwo-thirds of parents with children attending PWM programs report interest in TLE ≤12 hours/d regardless of demographic characteristics, but interest wanes when limiting eating to ≤10 or ≤8 hours per day. Time-limited eating appears to be a feasible option in PWM settings provided treatment options are individualized based on the interests and barriers of patients and their families.

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“…Obesity increases the risk of anovulation, menstrual irregularities, polycystic ovarian syndrome, and impaired endometrial receptivity and implantation, and obese women were found to be more than three times more likely to become infertile than normal-weight women [3]. Of particular note, it has been reported that low-income women ate larger quantities of food with a high glycemic index and lipid content [5]. Compounded by a lack of conditions for exercise and high treatment costs making medical access less accessible, low-income women are more likely to become obese [6].…”

Section: Introductionmentioning

confidence: 99%

Factors affecting unmet healthcare needs of low-income overweight and obese women in Korea: analysis of the Korean National Health and Nutrition Examination Survey 2017

Nho

Park

2021

Korean J Women Health Nurs

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The purpose of this study was to explore unmet healthcare needs among low-income overweight and obese women and to identify the factors affecting unmet healthcare needs. Methods: The study was a secondary analysis of data from the 2017 Korea National Health and Nutrition Examination Survey. A final sample of 388 out of 8,127 participants was analyzed using complex descriptive statistics, the chi-square test, the independent t-test, and logistic regression. Results: The mean age of the participants was 66.51±1.05 years. Unmet healthcare needs were experienced by 19.4% of low-income overweight and obese women. Women with depression, stress, and poor self-reported health status were significantly more likely than their counterparts to experience unmet healthcare needs. Poor self-reported health status was confirmed to be related to unmet health needs in low-income overweight and obese women (odds ratio, 2.65; p=.011). Conclusion:The study provides the novel insight that the unmet healthcare needs of low-income overweight and obese women were influenced by self-reported health status. Healthcare providers should make efforts to develop strategies to reduce unmet healthcare needs among low-income overweight and obese women, who constitute a vulnerable population.

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Acute effects of time-restricted feeding in low-income women with obesity placed on hypoenergetic diets: Randomized trial

Cited by 44 publications

References 34 publications

Time-Restricted Feeding Restored Insulin-Growth Hormone Balance and Improved Substrate and Energy Metabolism in MC4RKO Obese Mice

Time-Restricted Feeding Restored Insulin-Growth Hormone Balance and Improved Substrate and Energy Metabolism in MC4RKO Obese Mice

Acceptability of Time-Limited Eating in Pediatric Weight Management

Factors affecting unmet healthcare needs of low-income overweight and obese women in Korea: analysis of the Korean National Health and Nutrition Examination Survey 2017

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