Acute effects of treadmill running on lipoprotein(a) levels in males and females

Abstract

This investigation examined the acute response of serum lipoprotein(a) (Lp(a)) concentration immediately after, and during several days following, level and downhill motorized treadmill running. Eight males ran for 1 h on a level motorized treadmill at an intensity producing 90% maximum heart rate (MHR). On a separate occasion, three males and three females performed downhill (negative 13.4% incline) treadmill running at an intensity producing 75-80% MHR. For both protocols, serial blood samples were taken pre- and post-exercise and at the same time of day 1, 3, 5, and 7 days following exercise. Levels of Lp(a), creatine kinase (CK), C-reactive protein (CRP), and ferritin were measured. Repeated measures statistical analysis (Friedman ANOVA) showed no significant change in the median level of Lp(a) (level run, 5.0 mg.dl-1; downhill run, 7.45 mg.dl-1) across time following either protocol. After level running, ferritin levels 5 and 7 d post-exercise were significantly (P < 0.05) lower compared with immediately and 1 d post-exercise measures (Friedman ANOVA). Following level running, the Wilcoxon signed rank test showed significant (P < 0.05) elevations in CK levels immediately, 1 and 5 d post-exercise compared with pre-exercise values. Following downhill running. CK level was significantly elevated up to 3 d post-exercise (Wilcoxon signed rank). Calculated plasma volume did not change significantly following either protocol. These data suggest that Lp(a) does not change acutely in response to level or downhill treadmill running up to 60 min duration.

Does smoking status influence the effect of physical exercise on fibrinolytic function in healthy volunteers?

“…Moreover, as endothelial cells release t-PA and PAI-1, it has also been suggested that they could be related as marker of endothelial cell damage or dysfunction [19]. Finally, Lp(a) levels were decreased at plasma 30 minutes after exercise, possibly related to an improvement of fibrinolytic capacity, in contrast to studies that have failed to find a relationship between exercise and changes in plasma Lp(a) levels [20][21][22][23]. Smoking habit did not modify our findings, in spite of the basal high levels of Lp(a) observed in smokers compared to non smokers.…”

Exercise: An important component of treatment in the idiopathic inflammatory myopathies

“…Similar effects were reported on muscle tissue and in blood samples from groups of healthy individuals, suggesting that repeated muscle biopsies by itself may explain some of the previously reported signs of muscle inflammation; it is still uncertain how much muscle inflammation is caused by exercise itself [47•]. Furthermore, an acute raise of s-CK levels after physical exercise has been reported in numerous studies of healthy individuals [48•] usually returning to normal about 3 days post exercise [49]. During the past decade, 10 published studies have evaluated the safety and benefits of resistive exercise in patients with IIM, seven in polymyositis or dermatomyositis, and two in inclusion body myositis, and one study including all three ( Table 2).…”

Acute Responses of Inflammatory Markers of Cardiovascular Disease Risk to a Single Walking Session

“…Sixty minutes of level and 40 min of downhill treadmill running did not evoke significant changes in CRP. 36 Similarly, elevated CRP was not seen as an acute consequence of typical training of elite female netball and soccer teams. 37 Twenty-four maximal eccentric arm curls did not evoke significant alterations in CRP levels in 14 untrained males.…”