Acute effects of ultrasound on skeletal muscle oxygen tension, blood flow and capillary density

Rubin, Michael J.; Etchison, Michelle R.; Condra, K. A.; Franklin, Thomas D.; Snoddy, Andrew M.

doi:10.1016/0301-5629(90)90006-x

Cited by 25 publications

(11 citation statements)

References 13 publications

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“…Hogan et al (1982) reported that serial US irradiation of the ischemic rat cremaster muscle with 1-MHz transducer at intensities of 1.25 W/cm 2 to 10 W/cm 2 produced an increase in capillary density and vasodilatation in excess of that found in nonirradiated muscle. In contrast, Rubin et al (1990) found no effect of US irradiation on tissue blood flow and capillary density of rat cremaster muscle using 1-MHz transducer with intensities of 2.5 and 5 W/cm 2 . In comparison, we used lower US energy of 0.05 W/cm 2 and found a high number of blood vessels and tissue perfusion in moderate and severe limb ischemia, with higher VEGF mRNA expression in moderate ischemia.…”

Section: Discussionmentioning

confidence: 53%

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Low-intensity ultrasound induces angiogenesis in rat hind-limb ischemia

Barzelai

Sharabani-Yosef

Holbová

et al. 2006

Ultrasound in Medicine & Biology

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Section: Discussionmentioning

confidence: 53%

“…Martin et al (1982) demonstrated increased microstreaming in blood vessels of Xiphophorous maculates tropical fish. Irradiation of the ischemic cremaster muscle induced an increase in capillary density and arteriolar dilation in one study (Hogan et al 1982), but produced no effect in another study (Rubin et al 1990). …”

Section: Introductionmentioning

confidence: 95%

Low-intensity ultrasound induces angiogenesis in rat hind-limb ischemia

Barzelai

Sharabani-Yosef

Holbová

et al. 2006

Ultrasound in Medicine & Biology

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“…Previous studies have demonstrated that US has the potential to decrease blood flow in rat models [44-46] and human calf skin [47]. In the present study, the results demonstrated that application of US (whether pulsed or continuous) significantly decreases skin blood flow immediately after therapy, thus supporting the work by Ware et al There was a decrease in skin blood flow over time without the treatment (control/rest) as well, but the changes observed were smaller (≤1.0 AU) when compared to continuous US (3.5 AU) or pulsed US therapy (2.5 AU).…”

Section: Discussionmentioning

confidence: 99%

Short-term sensory and cutaneous vascular responses to therapeutic ultrasound in the forearms of healthy volunteers

Shaik

MacDermid

Birmingham

et al. 2014

Journal of Therapeutic Ultrasound

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BackgroundTherapeutic ultrasound (US) is used for a variety of clinical pathologies and is thought to accelerate tissue repair and help with pain reduction via its thermal and nonthermal effects. The evidence on physiological effects of US on both sensory and vascular functions in humans is incomplete. Hence, the purpose of this study was to determine the short-term impact of two doses of US (3 MHz, 1:4, 0.25 W/cm2, 5 min; 1 MHz, continuous, 0.8 W/cm2, 3 min), on sensory and vascular responses in the healthy forearms.MethodsTwenty healthy subjects were recruited (mean age, 29.6 ± 8.8 years) for the study. Superficial blood flow (SBF) in the distal forearms was determined using the tissue viability imaging system. Sensory perception thresholds (SPT) were determined from ring finger (C7, C8) to assess A-beta (at 2,000 Hz) and C fiber function (at 5 Hz), using a Neurometer CPT/C device. Subject’s two hands were randomly allocated to group order (AB/BA). Scores were obtained before and immediately after the application of US and control. Differences in these were analyzed using repeated measures.ResultsBoth 3 MHz pulsed US and 1 MHz continuous US showed small to moderate (effect size = 0.12 to 0.68), statistically significant reductions in SBF (3 MHz, mean change = 2.8 AU and 1 MHz, mean change = 3.9 AU, p < 0.05 respectively), skin temperature (2.5°C and 1.1°C, p < 0.05), and SPT at 5 Hz (1.3 and 1 mA, p < 0.05) across time. SPT at 2,000 Hz remained unaltered by all three conditions (p > 0.05). Age and gender also had no effect on all outcome measures (p > 0.05).ConclusionThis study demonstrated minor reductions in skin blood flow, skin temperatures, and C fiber perception thresholds immediately after 3 MHz, and 1 MHz US. The responses observed may have been due to a thermo-cooling effect of the gel or due to the direct effect of US on C fibers of median and ulnar nerves. US had a negligible effect on A-beta fibres. This would suggest that future studies looking at physiological effects of US should move towards investigating larger dosages and study the effects in patient populations.

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“…Für mehrfache Applikationen sind tierexperimentell sogar kurzfristige Wirkungen auf die Gefi3neubi1dung beobachtet worden (Young u. Dyson 1990). Einige Autoren fanden jedoch auch einen Abfall der lokalen Durchblutung nach Ultraschalleinwirkung (Dyson et al 1971, Klempe et al 1983, Rubin 1990). Diskutiert werden dabei Effekte ciner initialen Vasokonstriktion von Arteriolen (Hogan et a!.…”

Section: Introductionunclassified

“…Bei 0,9 W/cm2 scheint am Unterarm em Durchbiutungsanstieg erreicht, der auch mit 1,0W/cm2 nicht weiter gesteigert werden kann. Em suppressiver Effekt auf die lokale Durchb!utung wurde für Intensitäten ab 5 W/cm2 beschrieben (Rubin et al 1990). Küh!effekte durch Schallkopf und Koppelgel (Danz u. Callies 1978) sind zu berücksichtigen, dürflen jedoch aufgrund von Warme!eitung nur Auswirkungen auf die kutane Mikrozirkulation haben.…”

Section: Introductionunclassified